Choroidal Structural Changes and Vascularity Index in Stargardt Disease on Swept Source Optical Coherence Tomography

Ratra, Dhanashree; Tan, Roy; Jaishankar, Durgasri; Khandelwal, Neha; Gupta, Arushi; Chhablani, Jay; Agrawal, Rupesh

doi:10.1097/iae.0000000000001879

Cited by 42 publications

(40 citation statements)

References 27 publications

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“…Choriocapillaris loss in STGD has also been shown in prior OCTA studies. [42][43][44][45][46][47] Battaglia Parodi, et al, showed that CCVD was worse in STGD eyes that had chorioretinal atrophy, 46 and both Pellegrini, et al, and Muller, et al, found that the choriocapillaris flow signal was visibly diminished within areas of RPE atrophy in STGD, but not outside the areas of RPE atrophy. 42,47 Similar to these prior studies, the CCVD within areas of isolated RPE atrophy in our STGD patients was significantly lower than normal, but we also showed the same thing in areas of isolated IS/OS loss.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Outer Retinal Degeneration and Choriocapillaris Loss in Stargardt Disease Using En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography

Alabduljalil

Patel

Alqahtani

et al. 2019

American Journal of Ophthalmology

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Purpose: Measure and correlate degeneration of the inner segment/outer segment junction (IS/ OS), retinal pigment epithelium (RPE) and choriocapillaris (CC) in Stargardt disease (STGD) Design: Prospective cross-sectional study Methods Setting: Casey Eye Institute Population: 23 patients with STGD Procedures: OCT angiography (OCTA) scans were centered on the fovea. OCT slab projection and en face boundary maps were used to create masks to measure total IS/OS loss or RPE atrophy, as well as regions of isolated IS/OS loss, isolated RPE atrophy, matched IS/OS and RPE degeneration, or intact IS/OS and RPE. CC vascular density (CCVD) was quantified from CC angiogram. Outcome Measures: Area of loss and CCVD for different region types of degeneration were quantified and correlated. Results: The total area of IS/OS loss was strongly correlated with total area of RPE atrophy (r=0.96, p<0.0001) by a ratio of 1.6:1 (r 2 =0.90). CCVD within regions of matched degeneration

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Section: Discussionmentioning

confidence: 99%

Correlation of Outer Retinal Degeneration and Choriocapillaris Loss in Stargardt Disease Using En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography

Alabduljalil

Patel

Alqahtani

et al. 2019

American Journal of Ophthalmology

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“…Ratra et al showed that CVI was significantly reduced in SD as compared to normal eyes and that the reduction of CVI was correlated with worsening of visual acuity [25]. They suggested that this novel parameter appears to be a more sensitive biomarker in detecting choroidal changes as compared to subfoveal CT.…”

Section: In Inherited Retinal Disordersmentioning

confidence: 99%

Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter

Iovino

Pellegrini

Bernabei

et al. 2020

JCM

148

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Remarkable improvements in optical coherence tomography (OCT) technology have resulted in highly sophisticated, noninvasive machines allowing detailed and advanced morphological evaluation of all retinal and choroidal layers. Postproduction semiautomated imaging analysis with dedicated public-domain software allows precise quantitative analysis of binarized OCT images. In this regard, the choroidal vascularity index (CVI) is emerging as a new imaging tool for the measurement and analysis of the choroidal vascular system by quantifying both luminal and stromal choroidal components. Numerous reports have been published so far regarding CVI and its potential applications in healthy eyes as well as in the evaluation and management of several chorioretinal diseases. Current literature suggests that CVI has a lesser variability and is influenced by fewer physiologic factors as compared to choroidal thickness. It can be considered a relatively stable parameter for evaluating the changes in the choroidal vasculature. In this review, the principles and the applications of this advanced imaging modality for studying and understanding the contributing role of choroid in retinal and optic nerve diseases are discussed. Potential advances that may allow the widespread adoption of this tool in the routine clinical practice are also presented.

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“…Swept-source optical coherence tomography (SS-OCT) uses a longer wavelength than spectral domain OCT, penetrates tissues better and enables us to visualise the choroid 3 . Choroidal changes are evaluated in various systemic 4 and ocular [5][6][7][8][9][10][11] disorders.…”

Section: Introductionmentioning

confidence: 99%

Changes in subfoveal choroidal thickness after uncomplicated cataract surgery

Gudauskienė¹,

Matulevičiūtė²,

Mockutė³

et al. 2019

BIOMED PAP

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Background. Recent investigations show that phacoemulsification causing an inflammatory insult to the eye has an effect not only on retina but on the choroid as well. The purpose of this study was to evaluate the subfoveal choroidal thickness (SFCT) after uneventful phacoemulsification using swept-source optical coherence tomography (SS-OCT). Methods. This prospective study included 30 eyes of 23 patients with senile cataract undergoing uncomplicated phacoemulsification and intraocular lens implantation. SFCT and foveal retinal thickness (FRT) measurements were made at the same time, 1-2 PM preoperatively (P), 1 month (M1) and 3 months (M3) postoperatively using 1050 nm DRI Triton SS-OCT (Topcon, Tokyo, Japan). Postoperative changes in the SFCT, FRT and correlation of SFCT change with axial length, age, baseline intraocular pressure (IOP), IOP change were assessed. Results. The mean SFCT increased statistically significantly 3 months after surgery in all sectors except the superior inner region. Of the factors affecting the SFCT, the change in the SFCT (M3/P), correlation with age and baseline IOP in almost all sectors was observed. The mean FRT increased significantly after the surgery in all sectors. Conclusions. Insignificant subclinical increase in SFCT was observed 1 month after the cataract surgery. Significant increment in SFCT was detected 3 months postoperatively, which was correlated with surgery-induced IOP and ocular perfusion pressure change in the short term.

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Choroidal Structural Changes and Vascularity Index in Stargardt Disease on Swept Source Optical Coherence Tomography

Cited by 42 publications

References 27 publications

Correlation of Outer Retinal Degeneration and Choriocapillaris Loss in Stargardt Disease Using En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography

Correlation of Outer Retinal Degeneration and Choriocapillaris Loss in Stargardt Disease Using En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography

Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter

Changes in subfoveal choroidal thickness after uncomplicated cataract surgery

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