Choroidal Nevi in a White Population

Sumich, Peter; Mitchell, Paul; Wang, Jie Jin

doi:10.1001/archopht.116.5.645

Cited by 167 publications

(157 citation statements)

References 29 publications

(51 reference statements)

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“…4,8,15 In our study, the naevi were uniformly concentrated in the posterior pole. Both the numerical distribution and the merged fundus drawings demonstrated that choroidal naevi have a predilection for the macular region, without any significant nasotemporal or superoinferior asymmetry.…”

Section: Discussionsupporting

confidence: 45%

“…In a clinic-based study by Shields et al, 23 the mean naevus diameter was 5.1 mm, whereas the naevi in the population-based Blue Mountains Eye Study had a mean diameter of 1.25 mm. 4 In this study, 40% of the patients had been referred by ophthalmologists in practice and the remainder had been diagnosed in our department on routine examination or during treatment of other eye diseases.…”

Section: Discussionmentioning

confidence: 95%

“…[4][5][6]8,15,16 Even when variations in data collection and the outlining of fundus quadrants are taken into account, reports on their meridional or quadrantic distribution are more conflicting. Choroidal naevi and small melanocytic lesions have been shown to be rather evenly distributed Figure 1 Central points of 210 choroidal naevi plotted on a retinal chart with a macular centre surrounded by circles representing the equator, ora serrata, and limbus.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] A choroidal naevus usually presents as a flat or slightly elevated, brown to slate-grey lesion in the posterior fundus. The margins are typically indistinct, and often there are overlying drusen.…”

Section: Introductionmentioning

confidence: 99%

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Topographical distribution of choroidal naevi in the ocular fundus

Krohn

Frøystein

Dahl

2008

Eye

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Objective To analyse the topographical distribution of choroidal naevi and to visualise their location in the ocular fundus. Methods Data on the size and location of 210 choroidal naevi were converted into a database of two-dimensional retinal charts by means of computer-drawing software. The geometric centre of each lesion was entered into corresponding sectors of the retinal chart. The location of the naevi was computationally visualised by merging the fundus drawings and displaying the number of overlapping lesions on colour-coded contour maps. Results Five naevi were located exactly between two fundus sectors, and were therefore excluded from the distribution analysis. Ten naevi (5%) were located anterior and 195 (95%) posterior to the equator. A total of 104 naevi (51%) were located in the temporal and 101 (49%) in the nasal hemisphere, and the distribution between the superior and inferior hemisphere was 104 (51%) and 101 (49%), respectively. The distribution did not differ significantly between genders, age groups, or between right and left eyes. More naevi with a diameter of 43 mm were located in the temporal hemisphere (P ¼ 0.0004) and anterior to the equator (P ¼ 0.006) compared with those with a diameter of p3 mm. A similar distribution was found for naevi with overlying drusen. Conclusions Choroidal naevi are uniformly concentrated in the centre of the posterior pole without any significant nasotemporal or superoinferior asymmetry. However, large naevi occur significantly more often in the temporal hemisphere and more anteriorly compared with small lesions.

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Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Topographical distribution of choroidal naevi in the ocular fundus

Krohn

Frøystein

Dahl

2008

Eye

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“…Eye color, skin color and sun-induced skin damage had no association with choroidal nevi in an Australian study. 38 Thus, although cutaneous nevi, especially atypical nevi, are the strongest risk factors for cutaneous melanoma 39,40 the nature of the relationships between cutaneous and ocular nevi and ocular nevi and ocular melanoma is moot.…”

Section: Discussionmentioning

confidence: 99%

Eye color and cutaneous nevi predict risk of ocular melanoma in Australia

Vajdic¹,

Kricker

Giblin

et al. 2001

Int. J. Cancer

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Ethnicity, cutaneous nevi and eye color are generally accepted risk factors for melanoma of the eye, although casecontrol studies have produced conflicting results. We sought to determine the constitutional risk factors for melanomas of the choroid, ciliary body, iris and conjunctiva in Australia. A population-based case-control study was conducted, with case ascertainment from a prospective national incidence survey and randomly selected community controls. Two hundred and ninety cases aged 18 -79 years and diagnosed between 1st January 1996 and 31st July 1998 were enrolled with 916 controls frequency matched by age, sex and State or Territory of residence. Risk of choroidal and ciliary body melanoma (n ‫؍‬ 246) was increased in people with grey (OR 2.9, 95% CI 1.5-5.5), hazel (OR 2.2, 95% CI 1.4 -3.7) and blue eyes (OR 1.7, 95% CI 1.0 -2.7) compared with brown eyes. Risk was also increased in those with 4 or more nevi on their back, those unable to tan, and those who squinted when outdoors as a child. Risk was reduced in people born other than in Australia and New Zealand (OR 0.7, 95% CI 0.5-1.0). Non-brown eye color was a risk factor for iris melanoma (n ‫؍‬ 25). No risk factors were identified for conjunctival melanoma (n ‫؍‬ 19). Eye color is the strongest constitutional predictor of choroidal and ciliary body melanoma, and may indicate a protective effect of melanin density at these sites. An independent association with cutaneous nevi suggests a role for other genetic factors.

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Absence of Change in Choroidal Nevi Across 5 Years in an Older Population

Thiagalingam

Wang²

2004

Arch Ophthalmol

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To determine the proportion of choroidal nevi that were previously identified in a population cross section and that showed evidence of growth or progression during a 5-year period. Methods: The Blue Mountains Eye Study was a cohort study of residents 49 years and older living in an area west of Sydney, Australia. Retinal photographs were used to identify choroidal nevi. Repeat photographs were obtained 5 years later and graded side-by-side to ascertain clinical growth or progression of all identified nevi. The greatest diameter and surface area of each nevus were measured. Nevus growth was defined as an increase in size of at least 33%. Results: There were 160 choroidal nevi identified in the 128 subjects with nevi who participated in both eye examinations. Only 1 nevus (0.6%) exhibited clinical growth during the 5 years. No nevi developed other indicators of progression, such as subretinal fluid or orange pigment accumulation.

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Choroidal Nevi in a White Population

Cited by 167 publications

References 29 publications

Topographical distribution of choroidal naevi in the ocular fundus

Topographical distribution of choroidal naevi in the ocular fundus

Eye color and cutaneous nevi predict risk of ocular melanoma in Australia

Absence of Change in Choroidal Nevi Across 5 Years in an Older Population

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