Choroidal metastasis—the initial presentation of breast carcinoma

Williams, Nick; Leris, A.C.A.; Kouriefs, Chryssanthos; Mokbel, KM; Hungerford, J. L.; Carpenter, R

doi:10.1053/ejso.2000.1012

Cited by 8 publications

(6 citation statements)

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“…Ocular metastasis can represent the initial manifestation of breast carcinoma. Several series report the eyes as the initial site of disease (Chen et al 1998;Williams et al 2000;O'Gorman et al 2001;Demirci et al 2003). Tumour metastases may give rise to both intraand extraocular sequelae.…”

Section: Ophthalmic Metastases In Breast Cancermentioning

confidence: 99%

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Ocular presentations of breast cancer

Wickremasinghe

Dansingani

Tranos

et al. 2006

Acta Ophthalmologica Scandinavica

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IntroductionBreast cancer is the most common malignancy in women (Office of National Statistics 2002). As ophthalmic manifestations are common, the astute ophthalmologist can instigate the search for primary disease when the first presentation is ophthalmic in nature, or, alternatively, play an important role in detecting the metastatic spread of a known primary. Breast cancer accounts for 29% of new malignancies in women in the UK and is a major cause of mortality and morbidity worldwide.The purpose of this article is to provide a review of the ophthalmic manifestations of breast cancer. The subjects covered include the presenting features of metastatic disease involving the visual systems, treatment modalities and strategies currently available, and the ocular effects and complications of treatment. EpidemiologyIncidence rates of breast cancer have increased over the last decade, rising from 90 to 130 per 100 000 population (1988 versus 1998) (Office of National Statistics 2002). In contrast, mortality rates have remained relatively stable since the 1950s. This increase in the incidence of breast cancer is attributed to more effective screening programmes, although a change in the demographics of developed countries and an increasing elderly population may contribute to the growing incidence. Geographical variations exist in breast cancer incidence rates, with higher rates in Europe, North America and Oceania and lower rates in Asia and Africa (Sasco 2001). Doctors practising in the western world should be familiar with the disease.Male breast cancer is rare. The incidence is 0.8-1.5 cases per 100 000 male population, accounting for 1% of all breast cancer diagnoses (Office of National Statistics 2002; Hodgson et al. 2004). The highest incidence occurs in men aged over 70 years (Kidmas et al. 2005). In families with hereditary breast cancer, younger males may be affected. The BRCA2 gene is often implicated in these cases (Lorenzo Bermejo & Hemminki 2005).Ocular manifestations of male breast cancer can occur and this differential diagnosis should not be overlooked (O'Brien et al. 2000;Silvestris et al. 2003;Dieing et al. 2004). Ophthalmic metastases in breast cancerMetastatic disease to the eye from the breast was first described by Johann ABSTRACT.Context: Breast cancer is the most common malignancy in women, with increasing incidence in Europe and North America. The frequency of involvement of the eye and visual pathways is reported to be as high as 30% in patients with known metastatic disease. In some cases, ophthalmic involvement can be the first sign of metastatic spread. Metastasis occurs via the haematogenous route and predominantly involves the choroid. Metastases to other ocular structures, the orbit and the visual pathways have also been described. Paraneoplastic effects are rare but significant. Treatments: Different modalities are employed in the treatment of breast cancer and its metastases. These include chemotherapy and radiotherapy. The ocular adverse effects of these have been well described,...

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Section: Ophthalmic Metastases In Breast Cancermentioning

confidence: 99%

“…Several series report the eyes as the initial site of disease (Chen et al. 1998; Williams et al. 2000; O'Gorman et al.…”

Section: Ophthalmic Metastases In Breast Cancermentioning

confidence: 99%

Ocular presentations of breast cancer

Wickremasinghe

Dansingani

Tranos

et al. 2006

Acta Ophthalmologica Scandinavica

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“…Visual symptoms from choroidal metastases are rarely the initial manifestation of primary breast carcinoma, even in women. 1 Male breast cancer differs from female breast cancer in many ways. The average age of the male patients at diagnosis is 60 years (10 years older than women).…”

Section: Commentmentioning

confidence: 99%

Tamoxifen-Induced Regression of a Choroidal Metastasis in a Man

Cohen¹,

Moosavi²,

Hungerford³

2005

Arch Ophthalmol

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“…It was then shown that patients, who did not have orchidectomy and failed after aminoglutethimide treatment, responded to tamoxifen [75]. Tamoxifen therapy for metastatic disease was quite well established in the early 90s [76], and there are reports of complete regression of metastasis from MBC from the use of tamoxifen [42,77,78]. Its use in the adjuvant setting is accepted by most people [79], largely because patients with MBC find it more acceptable than orchidectomy [80], but surprisingly, it has more reported side effects in men than in women, with a drop-out rate of about 20% in less than a year [81].…”

Section: Endocrine Therapymentioning

confidence: 99%

The ‘other half’ of breast cancer: A review of male breast cancer

Ying¹,

Agrawal²,

Cheung³

2005

The Journal of Men's Health & Gender

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Male breast cancer has always been shadowed by the attention received by its other half of the coin; female breast cancer. It is widely known to be 1% of all breast cancer, constituting also about 1% of all breast cancer literature. As a rare disease, it is fortunate that its female counterpart has provided it with the wealth of knowledge to treat it effectively. Although very similar, male breast cancer has unique characteristics requiring a different approach to female breast cancer. In this review, the cause, prognosis, psychosocial effect and treatment options of male breast cancer are discussed, paying particular attention to endocrine therapy.

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Choroidal metastasis—the initial presentation of breast carcinoma

Cited by 8 publications

References 1 publication

Ocular presentations of breast cancer

Ocular presentations of breast cancer

Tamoxifen-Induced Regression of a Choroidal Metastasis in a Man

The ‘other half’ of breast cancer: A review of male breast cancer

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