Choroidal Changes and Duration of Diabetes

Yülek, Fatma; Uğurlu, Nagihan; Önal, Eda Demir; Kocamış, Sücattin İlker; Çağıl, Nurullah; Ersoy, Reyhan; Çakır, Bekir

doi:10.3109/08820538.2013.821504

Cited by 17 publications

(5 citation statements)

References 15 publications

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“…The population-based Beijing Eye study 17 also found that DM can lead to a slight thickening of the choroid, although not related to the severity of DR. Yulek et al concluded that subfoveal CT was not significantly correlated with increased duration of diabetes. 39 Regatieri et al, 10 however, reported a thinner CT in patients with diabetic macular edema or treated proliferative DR compared with normal subjects. Vujosevic et al, 11 Esmaeelpour et al, 12 , 13 Querques et al 14 and Shen et al 15 also demonstrated that CT decreases in diabetic eyes with clinical signs of DR compared with controls.…”

Section: Discussionmentioning

confidence: 96%

Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography

Benfica¹,

Zanella²,

Farias³

et al. 2018

OPTH

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PurposeTo analyze choroidal thickness (CT) of pregnant women with type 1 diabetes mellitus (DM), type 2 DM and gestational diabetes mellitus (GDM) using spectral-domain optical coherence tomography.Patients and methodsThis cross-sectional study included 144 eyes of 72 pregnant women in the third trimester divided into four groups: 27 non-diabetic pregnant women; 15 pregnant women with GDM; 16 with type 2 DM and 14 with type 1 DM. CT was measured using optical coherence tomography at ten different locations. We also analyzed possible confounding factors, such as gestational age, glycosylated hemoglobin, time from DM diagnosis, hypertension and severity of diabetic retinopathy.ResultsThe comparison between the four groups showed a thinner choroid in patients with type 1 DM in all locations, with statistical significance in subfoveal and temporal measurements. When comparing only patients with type 1 and type 2 DM, adjusting for confounding factors, the choroid of patients with type 1 DM remained thinner at all macular points, also with statistical significance in subfoveal and temporal measurements.ConclusionPregnant women with type 1 DM had significantly thinner CT measurements on subfoveal and temporal locations. No differences were found in CT between the control group and pregnant women with GDM and type 2 DM.

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Section: Discussionmentioning

confidence: 96%

Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography

Benfica¹,

Zanella²,

Farias³

et al. 2018

OPTH

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“…Controversially ChT increased in eyes with severe NPDR and PDR in another study (47). It has also been reported that there is no relationship between the duration of DM and ChT (48).…”

Section: Discussionmentioning

confidence: 84%

The Measurement of the Choroidal Thickness During Oral Glucose Tolerance Tests in Prediabetic Subjects: A Spectral Domain Optical Coherence Tomography Study

Çağıltay¹,

Altınışık²,

Pouwels³

et al. 2020

J Istanb Fac Med

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Akut hiperglisemik değişikliklerin prediyabetli hastalarda koroidi nasıl etkilediğini araştırmak. Gereç ve Yöntem: Hastalara en az 8 saat kalori alınmaması sonrası 75 g oral glukoz tolerans testi (OGTT) uygulandı. Koroid kalınlığı (ChT), yeni nesil spektral domain optik koherens tomografi (SD-OCT) ile ölçüldü. Bulgular: Koroid kalınlığındaki değişiklikler gruplar arasında farklılık göstermiştir. Prediyabetli bireylerde, foveaya 500 µm mesafedeki subfoveal, nazal ve temporal lokasyonların yanı sıra ortalama ChT'de geçici bir artış gözlenmiştir. OGTT'nin ilk saatinde; prediyabetik grupta subfoveal koroid kalınlığı farkı 1,52±4,11 µm (aralık,-11,00/24,00 µm) iken, kontrol grubunda subfoveal ChT farkı-0,22±1,74 µm (aralık-2,00/8,00 µm) olarak ölçüldü. Sonuç: Akut hiperglisemik değişikliklerin anlık ölçümlerle saptanması, hastalığın oküler yapılar üzerindeki etkisini daha iyi anlamamıza yardımcı olabilir.

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“…Choroidal thinning indicates diabetes-related hemodynamic changes, such as blood flow disturbances and vascular endothelial dysfunction. 27 Choroidal thinning for blood flow disturbances might lead to ischemia and hypoxia in the RPE and the subsequent production of vascular endothelial growth factor that leads to choroidal neovascularization. 28 , 29 Lower CT may also be a sign of impaired self-regulation of small arteries, and this process could lead to capillary wall dilatation (microaneurysms), leakage (edema and hard exudate), and rupture (hemorrhage).…”

Section: Discussionmentioning

confidence: 99%

Macular Choroidal Thickness and the Risk of Referable Diabetic Retinopathy in Type 2 Diabetes: A 2-Year Longitudinal Study

Wang

et al. 2022

Invest. Ophthalmol. Vis. Sci.

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Purpose The purpose of this study was to evaluate the associations between choroidal thickness (CT) and the 2-year incidence of referable diabetic retinopathy (RDR). Methods This was a prospective cohort study. Patients with type 2 diabetes in Guangzhou, China, aged 30 to 80 years underwent comprehensive examinations, including standard 7-field fundus photography. Macular CT was measured using a commercial swept-source optical coherence tomography (SS-OCT) device (DRI OCT Triton; Topcon, Tokyo, Japan). The relative risk (RR) with 95% confidence intervals (CIs) was used to quantify the association between CT and new-onset RDR. The prognostic value of CT was assessed using the area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Results A total of 1345 patients with diabetes were included in the study, and 120 (8.92%) of them had newly developed RDR at the 2-year follow-up. After adjusting for other factors, the increased RDR risk was associated with greater HbA1c (RR = 1.35, 95% CI = 1.17–1.55, P < 0.001), higher systolic blood pressure (SBP; RR = 1.02, 95% CI = 1.01–1.03, P = 0.005), lower triglyceride (TG) level (RR = 0.81, 95% CI = 0.69–0.96, P = 0.015), presence of diabetic retinopathy (DR; RR = 8.16, 95% CI = 4.47–14.89, P < 0.001), and thinner average CT (RR = 0.903, 95% CI = 0.871–0.935, P < 0.001). The addition of average CT improved NRI (0.464 ± 0.096, P < 0.001) and IDI (0.0321 ± 0.0068, P < 0.001) for risk of RDR, and it also improved the AUC from 0.708 (95% CI = 0.659–0.757) to 0.761 (95% CI = 0.719–0.804). Conclusions CT thinning measured by SS-OCT is an early imaging biomarker for the development of RDR, suggesting that alterations in CT play an essential role in DR occurrence.

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Choroidal Changes and Duration of Diabetes

Cited by 17 publications

References 15 publications

Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography

Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography

The Measurement of the Choroidal Thickness During Oral Glucose Tolerance Tests in Prediabetic Subjects: A Spectral Domain Optical Coherence Tomography Study

Macular Choroidal Thickness and the Risk of Referable Diabetic Retinopathy in Type 2 Diabetes: A 2-Year Longitudinal Study

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