Choroid Plexus Papilloma and Factor XIII Deficiency: Case Report

Abstract

Factor XIII deficiency is a rare hemorrhagic disorder that can cause spontaneous intracranial hemorrhage and bleeding after surgery. The diagnosis of factor XIII deficiency is difficult before surgical interventions, because coagulation parameters are normal in these patients. Important clinical findings are postsurgical bleeding and recurrent spontaneous intracranial hematomas. These findings should raise the clinical suspicion of factor XIII deficiency. Therefore, diagnosis of factor XIII deficiency is very important for neurologists and neurosurgeons in terms of reducing mortality and morbidity. We present an 8-month-old female patient who developed subdural hematoma after ventriculoperitoneal shunt surgery but not bleeding after choroid plexus papilloma due to FXIII deficiency.

Factor XIII Deficiency and Intracranial Bleed: Surgical Management and Prophylaxis with Cryoprecipitate

“…1 About 28 to 32% of patients with FXIII deficiency develop intracranial bleed; 85 to 92% of them have intraparenchymal bleed. 3 4 5 The aim of this report is to provide an effective alternative to FXIII concentrate in the form of cryoprecipitate in perioperative setting especially when the FXIII concentrate is unavailable.…”