Chorionic villus sampling (CVS): World health organization european regional office (WHO/EURO) meeting statement on the use of CVS in prenatal diagnosis

Kuliev, Anver; Modell, Bernadette; Jackson, Laird; Jl, Simpson; Brambati, B.; Rhoads, George G.; Froster, UrsulaG.; Verlinsky, Yury; Smidt‐Jensen, Steen; Holzgreve, Wolfgang

doi:10.1007/bf01203947

Cited by 11 publications

(6 citation statements)

References 9 publications

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“…Our observations are consistent with the conclusions drawn from the World Health Organization database, suggesting no relationship between limb reduction and CVS (Kuliev et al, 1994). This fact notwithstanding, it is essential that all centres offering this procedure counsel patients regarding this concern and share their own data related to congenital malformation.…”

Section: Discussionsupporting

confidence: 91%

Congenital malformations subsequent to chorionic villus sampling: Outcome analysis of 1048 consecutive procedures

et al. 1994

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We wished to identify the types and frequencies of malformations among continuing pregnancies exposed to chorionic villus sampling (CVS) and to determine whether selected procedure-related variables differ between the normal and anomalous cohorts. CVS was performed in 1048 patients between May 1988 and January 1992. Prospective assessment of perinatal outcome was ascertained by (1) physician-patient phone contact within 1 week of sampling, (2) ultrasound evaluation of the fetal anatomy at mid-gestation, (3) a detailed post-partum questionnaire completed by the referring obstetrician, and (4) a telephone interview with each patient after the expected date of confinement. Twenty-seven major malformations were documented among 938 pregnancies (live born, n = 934; electively terminated, n = 4), and included cardiac malformations (5), hypospadias (5), craniosynostosis (2), pyloric stenosis (2), inguinal hernia (2), polydactyly (2), syndactyly, distal extremely hemimelia, anencephaly, hydrocephalus, cleft lip and palate, omphalocele, diaphragmatic hernia, thanatophoric dysplasia, and unilateral cataract. Normal and anomalous cohorts were similar with respect to sampling method (transabdominal/transcervical ratio), mean gestational age at CVS, single-pass success rate, and mean total sample weight. No relationship between any procedure-related variable and the risk of malformation was observed.

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Section: Discussionsupporting

confidence: 91%

Congenital malformations subsequent to chorionic villus sampling: Outcome analysis of 1048 consecutive procedures

et al. 1994

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“…To avoid this dis advantage, CVS was introduced to prenatal diagnosis 12 years ago. The acceptance of CVS was hampered for a few years because of the widespread discussions on fetal limb reduction defects and the impression that CVS may be associated with higher abortion rates, but in the mean time these problems have been cleared [2][3][4][5].…”

Section: Discussionmentioning

confidence: 99%

On the Complication Risk of Early Amniocentesis versus Standard Amniocentesis

Eiben¹,

Hammans²,

Hansen³

et al. 1997

Fetal Diagn Ther

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In the last 6 years early amniocentesis for the prenatal diagnosis of chromosome aberrations has been established in many centers worldwide, but knowledge about the gynecological safety of the procedure is sparse. From 1990 to 1995 at the Evangelisches Krankenhaus Oberhausen (Germany) 3,277 early amniocenteses (between weeks 11 and 14) and 1,808 standard amniocenteses were performed in low-risk indication groups (advanced maternal age and anxiety). A complete follow-up including reports of fetal outcome was obtained in 4,444 cases (87.5%). A pregnancy age-related abortion rate was determined with a slightly higher rate of abortions up to week 28 of gestation in early amniocentesis. The total abortion rate up to week 28 after the procedure for cases with complete follow-up was 2% in early amniocentesis. Compared to standard amniocentesis performed under the same clinical conditions with an abortion rate of 1.3%, there is no statistical difference between early and standard amniocentesis (p = 0.0971). Hip and foot dislocations (22 cases) and pulmonary distress syndromes (8 newborns) showed no significant correlation with the gestational week. Given the high normal background rate of spontaneous abortions in the early period of pregnancy without an invasive procedure, early amniocentesis can be considered as a safe alternative to chorionic villus sampling and standard amniocentesis.

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“…World Health Organization (WHO) estimates that about 250 procedures are required to achieve experience and systemic sampling thereafter is necessary in order to maintain adequate skills. 23 Furthermore, a WHO meeting proposed specific criteria for the self-evaluation of centers performing CVS 24 (Table 2). According to the standards first issued by the Dutch Society of Obstetrics and Gynecology in 1986, qualified gynecologists had to perform at least 50 training procedures in patients scheduled for termination of pregnancy and 15 super vised CVS before practicing on their own.…”

Section: Trainingmentioning

confidence: 99%

Invasive Prenatal Diagnosis: Chorionic Villus Sampling

Antsaklis¹,

Antsaklis²,

Sindos³

et al. 2015

Donald School Journal of Ultrasound in Obstetrics and Gynecology

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Chorionic villus sampling (CVS) is the method of choice for first trimester invasive prenatal diagnosis. In expert hands, it is nowadays considered as safe as amniocentesis and has the advantage of an earlier diagnosis. In this review, we describe the technique of the procedure, its indications and contraindications and the requirements concerning adequate training and optimum clinical practice. We also discuss issues concerning the safety of the procedure in singleton and multiple pregnancies, other complications and controversies, such as the association with limb reduction defects and pre-eclampsia, as well as diagnostic problems and dilemmas, such as maternal cell contamination and confined placental mosaicism. We also describe new and promising methods of non-invasive diagnosis, based on the isolation and analysis of fetal cells or cell-free fetal genetic material from the maternal circulation, that aim to replace the invasive methods of prenatal diagnosis in the future. How to cite this article Sindos M, Malamas FM, Antsaklis P, Antsaklis A. Invasive Prenatal Diagnosis: Chorionic Villus Sampling. Donald School J Ultrasound Obstet Gynecol 2015; 9(3):293-306.

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Chorionic villus sampling (CVS): World health organization european regional office (WHO/EURO) meeting statement on the use of CVS in prenatal diagnosis

Cited by 11 publications

References 9 publications

Congenital malformations subsequent to chorionic villus sampling: Outcome analysis of 1048 consecutive procedures

Congenital malformations subsequent to chorionic villus sampling: Outcome analysis of 1048 consecutive procedures

On the Complication Risk of Early Amniocentesis versus Standard Amniocentesis

Invasive Prenatal Diagnosis: Chorionic Villus Sampling

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