1958
DOI: 10.1001/jama.1958.62990050001011
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Choriocarcinoma in Mother and Infant

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Cited by 49 publications
(6 citation statements)
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“…Surgery [2,9,19,24,36] or single agent chemotherapy [1,3,10,22] alone (methotrexate monotherapy [3,10], doxorubicin plus dexamethasone [1,22]) did not alter the prognosis. Seven infants received combined modality treatment including a platinum-containing chemotherapy [5,6,14,15,16,32,33], in five of these patients a sustained remission was achieved by combining multiagent chemotherapy with delayed (4/5) [6,14,15,33] or primary tumour resection (1/5) [5].…”
Section: Treatment and Outcomementioning
confidence: 94%
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“…Surgery [2,9,19,24,36] or single agent chemotherapy [1,3,10,22] alone (methotrexate monotherapy [3,10], doxorubicin plus dexamethasone [1,22]) did not alter the prognosis. Seven infants received combined modality treatment including a platinum-containing chemotherapy [5,6,14,15,16,32,33], in five of these patients a sustained remission was achieved by combining multiagent chemotherapy with delayed (4/5) [6,14,15,33] or primary tumour resection (1/5) [5].…”
Section: Treatment and Outcomementioning
confidence: 94%
“…This may lead to haematogenous metastases in the mother and/or offspring resulting in early infantile death. To the authors' knowledge, 30 different neonates and infants including two stillbirths affected by the disease have been reported in the literature [1,2,3,5,6,7,8,9,10,11,12,13,14,15,16,18,19,20,21,22,23,24,25,26,27,29,30,32,33,35,36]. The prognosis of affected children may be improved by early diagnosis and institution of the appropriate treatment, as demonstrated in five infants [5,6,14,15,33].…”
Section: Introductionmentioning
confidence: 95%
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