Unexplained anaemia and failure to thrive as initial symptoms of infantile choriocarcinoma: a review

Blohm, Martin; Göbel, U.

doi:10.1007/s00431-003-1361-1

Cited by 43 publications

(41 citation statements)

References 32 publications

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“…Typical early symptoms of decreasing incidence are anemia, failure to thrive, hepatomegaly, hemoptysis or respiratory failure; there may be signs of precocious puberty. The tumor affected more than one organ in most cases; organs involved were liver, lung, brain, or skin [1,5]. β-Human chorionic gonadotropin universally elevated in 19/19 tested infants.…”

Section: Discussionmentioning

confidence: 97%

“…In the absence of a known maternal choriocarcinoma, the diagnosis is frequently incorrect because of the rarity of the lesion and the non-specific MRI findings [3]. Choriocarcinoma in children only reported in 30 cases [1]. Latest concept of choriocarcinoma mentioned that choriocarcinoma in children is also originated from the placenta as well [1,4].…”

Section: Discussionmentioning

confidence: 99%

“…Choriocarcinoma in children only reported in 30 cases [1]. Latest concept of choriocarcinoma mentioned that choriocarcinoma in children is also originated from the placenta as well [1,4]. Reviewed find that the symptom of children suffering from infantile choriocarcinoma become symptomatic at a median age of 1 month (range 0 days-5 months) [1].…”

Section: Discussionmentioning

confidence: 99%

“…Latest concept of choriocarcinoma mentioned that choriocarcinoma in children is also originated from the placenta as well [1,4]. Reviewed find that the symptom of children suffering from infantile choriocarcinoma become symptomatic at a median age of 1 month (range 0 days-5 months) [1]. Typical early symptoms of decreasing incidence are anemia, failure to thrive, hepatomegaly, hemoptysis or respiratory failure; there may be signs of precocious puberty.…”

Section: Discussionmentioning

confidence: 99%

“…Choriocarcinoma in children is extremely rare, and so far up to the year 2004 were reported is only 30 children [1]. Because of the rarity disease in children, the diagnosis and treatment are usually late.…”

Section: Introductionmentioning

confidence: 99%

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Choriocarcionoma in an Infantile Patient

Pradjatmo¹

2015

Gen Med (Los Angel)

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Clinical diagnosis of choriocarcinoma may be difficult in post-menopause or children and ectopic origin. According to its histologic origin, it is classified as gestational or nongestational choriocarcinoma. Gestational choriocarcinoma its origin derived from placental trophoblast and nongestational choriocarcinoma-derived from a germ cell. However, DNA and genetic analysis can be used to define the origin of choriocarcinoma. Usually, the DNA examination and genetic analysis have not been used widely in clinical services. In this case the diagnosis to considered as a primary nongestational choriocarcinoma just based on clinical and laboratory finding. This article is aimed to remind the doctors who treat cases choriocarcinoma and is no doubt in deciding whether the origin of the disease from gestational or nongestational should carry out an investigation DNA and genetic analysis.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Choriocarcionoma in an Infantile Patient

Pradjatmo¹

2015

Gen Med (Los Angel)

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Treatment of infantile choriocarcinoma of the liver

Yoon

Burns

Malogolowkin

et al. 2007

Pediatric Blood & Cancer

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Primary choriocarcinoma of the liver is an extremely rare childhood malignancy frequently associated with clinical instability at initial presentation. It often mimics other benign and malignant childhood liver tumors. Prompt diagnosis and initiation of treatment are necessary to attain a successful outcome. We describe a critically ill infant with metastatic choriocarcinoma whose diagnosis was based on radiographic and tumor marker findings, without an initial biopsy, and her successful management with neo-adjuvant chemotherapy and delayed surgery. She is currently in continuous remission 24 months from diagnosis.

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Congenital Tumors

Charles¹

2007

Fetal and Neonatal Pathology

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Unexplained anaemia and failure to thrive as initial symptoms of infantile choriocarcinoma: a review

Abstract: The differential diagnosis of infantile anaemia, failure to thrive and liver enlargement should include infantile choriocarcinoma and prompt measurement of beta-human chorionic gonadotropin.

Cited by 43 publications

References 32 publications

Choriocarcionoma in an Infantile Patient

Choriocarcionoma in an Infantile Patient

Treatment of infantile choriocarcinoma of the liver

Congenital Tumors

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