Chorea induced by oral contraceptives

Chorea and contraceptives: Case report with pet study and review of the literature

“…Asherson highlighted this association as a potential risk factor for OC‐related complications 6. Once an essay for detection of aPL became available, aPL were in fact found in 11 cases of OC‐induced chorea 3–7, 25…”

“…With regards to the vascular hypothesis, it is well known that OCs increase the risk of stroke 31. A vascular mechanism has been proposed especially in patients with OC‐induced chorea who have SLE or positive aPL 3, 7. Moreover, the possibility has been raised that auto‐antibodies may represent an added risk factor for the development of thrombotic complications in patients who take OCs 3, 32…”

“…Since then, more than 50 cases have been described, usually in the form of case reports or letters. Most patients had a past history of basal ganglia abnormalities, such as Sydenham's chorea (SC)2, 3 or chorea gravidarum (CG)2; others had systemic lupu s erythematosus (SLE)4, 5 or the presence of antiphospholipid antibodies (aPL) 6, 7. However, there were some patients without any other known risk factor.…”

Movimentos involuntários anormais como primeira manifestação do lupus eritematoso sistêmico: relato de caso

“…Ao contrário do que ocorre com a cefaléia e o acidente vascular cerebral, a coréia é infrequente, incidindo em menos de 4% dos casos, usualmente acompanhada de outros sintomas de disfunção do sistema nervoso central 2 e, raramente, como primeira manifestação da enfermidade. A coréia pode também ocorrer como manifestação da síndrome antifosfolípide primária 3,4 ou como efeito colateral do uso dos anticoncepcionais orais [5][6][7] . Descrevemos um caso clínico onde a coréia foi a primeira manifestação do LES, em paciente com história pregressa de uso recente de anticontraceptivo hormonal, e pesquisa para anticorpos antifosfolípide negativa.…”