Chordoma: a case series and review of the literature

Alan, Özkan; Telli, Tuğba Akın; Ercelep, Özlem; Şimşek, Eda Tanrikulu; Tüylü, Tuğba Başoğlu; Mutis, Aydan; Hasanov, Rahib; Kaya, Serap; Babacan, Nalân Akgül; Dane, Faysal; Yumuk, Perran Fulden

doi:10.1186/s13256-018-1784-y

Cited by 23 publications

(11 citation statements)

References 16 publications

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“…Controversy over aggressive tumor resection in skull base chordomas arises from the tumor's relationship to critical neurovascular structures and that total resection often results in significant morbidity (2,7,8). Tumor diameter and aggressive growth pattern, previous surgery and radiation therapy have been found to be associated with postoperative morbidity rates (7,8,17,18). Although modern skull base techniques implemented in experienced centers have reduced the mortality and morbidity associated with chordoma resection, chordomas are considered to be tumors that cannot be curable surgically (2,(4)(5)(6)17).…”

Section: Discussionmentioning

confidence: 99%

Intraoperative Magnetic Resonance Imaging Assisted Endoscopic Endonasal Resection of Clival Chordomas

et al. 2022

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BackgroundCranial base chordomas are typically indolent and usually appear as encapsulated tumors. They slowly grow by infiltrating the bone, along with the lines of least resistance. Due to its relationship with important neurovascular structures, skull base chordoma surgery is challenging.ObjectiveThe usefulness of intraoperative magnetic resonance imaging (IO-MRI) in achieving the goal of surgery, is evaluated in this study.MethodsBetween March 2018 and March 2020, 42 patients were operated on for resection of skull base chordomas in our institution. All of them were operated on under IO-MRI. Patients were analyzed retrospectively for identifying common residue locations, complications and early post-operative outcomes.ResultsIn 22 patients (52,4%) gross total resection was achieved according to the final IO-MRI. In 20 patients (47,6%) complete tumor removal was not possible because of extension to the petrous bone (8 patients), pontocerebellar angle (6 patients), prepontine cistern (4 patients), temporobasal (1 patient), cervical axis (1 patient). In 13 patients, the surgery was continued after the first IO-MRI control was performed, which showed a resectable residual tumor. 7 of these patients achieved total resection according to the second IO-MRI, in the other 6 patients all efforts were made to ensure maximal resection of the tumor as much as possible without morbidity. Repeated IO-MRI helped achieve gross total resection in 7 patients (53.8%).ConclusionsOur study proves that the use of IO-MRI is a safe method that provides the opportunity to show the degree of resection in skull base chordomas and to evaluate the volume and location of the residual tumor intraoperatively. Hence IO-MRI can improve the life expectancy of patients because it provides an opportunity for both gross total resection and maximal safe resection in cases where total resection is not possible.

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Section: Discussionmentioning

confidence: 99%

Intraoperative Magnetic Resonance Imaging Assisted Endoscopic Endonasal Resection of Clival Chordomas

et al. 2022

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“… 4 Cytotoxic drugs are not recommended, however, tyrosine kinase inhibitors (TKI) may help to achieve a stable disease state in patients with widespread or recurrent chordoma who cannot tolerate further surgical or radiotherapeutic intervention. 8 …”

Section: Discussionmentioning

confidence: 99%

Recurrent Sacral Chordoma: A Case Report

Shrestha¹,

Nakarmi²,

Vaidya³

et al. 2020

J Nepal Med Assoc

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Chordoma is a rare and locally aggressive tumor that arises from the notochordal remnants and has an incidence of 0.1/100000 per year. It has a predilection for the axial skeleton and is the most common primary malignant tumor of sacrum. The mainstay of treatment is wide surgical excision but there is a risk of recurrence due to the infiltrating nature of the tumor. Here, we report a case of a 56-years male who complained of pain over his sacral region for the past two years along with episodic urinary symptoms, constipation, and weakness of both legs. Seven years after undergoing surgery and radiotherapy for his sacral chordoma, he was diagnosed with recurrent sacral chordoma and planned for reoperation. Subtotal excision of the chordoma was done which significantly alleviated his symptoms postoperatively. Timely intervention helps to improve the quality of life in patients with either primary or recurrent sacral chordomas.

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“…Therefore, chordoma resection is associated with a high risk of morbidity and mortality. In addition, the epidemiology of chordoma is unclear ( 9 ), particularly as regards its incidence rates and the most frequently affected parts of the axial skeleton ( 10 , 11 ). This is clinically significant, since the symptoms and treatment strategies of chordoma largely depend on its anatomical location ( 12 , 13 ).…”

Section: Discussionmentioning

confidence: 99%

Sacral and thoracic chordoma with pulmonary metastases: A case report and review of the literature

et al. 2020

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Chordoma is a sporadic type of cancer that affects the spine and is particularly challenging to treat due to the paucity of reported cases and scientific literature. In particular, primary chordomas affecting both the sacral and thoracic vertebrae are extremely rare. We herein report a rare case of chordoma in the sacral and thoracic vertebrae with pulmonary metastasis, along with a literature review. The objective of the present study was to explore treatment options and long-term outcomes in patients with metastatic chordoma. Posterior decompression was performed for the thoracic tumor, followed by extended resection of the sacral tumor. The symptoms of the patient were relieved after surgery, and the postoperative Nurick score decreased from grade 3 to grade 2, while the postoperative McCormick score was I. Therefore, complete chordoma excision and internal spinal fixation may effectively reduce tumor recurrence and metastasis.

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Chordoma: a case series and review of the literature

Cited by 23 publications

References 16 publications

Intraoperative Magnetic Resonance Imaging Assisted Endoscopic Endonasal Resection of Clival Chordomas

Intraoperative Magnetic Resonance Imaging Assisted Endoscopic Endonasal Resection of Clival Chordomas

Recurrent Sacral Chordoma: A Case Report

Sacral and thoracic chordoma with pulmonary metastases: A case report and review of the literature

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