Chorangioma of placenta with high risk pregnancy: A case series

Abstract

Chorangioma is the most common benign tumor of placenta, with an incidence of approximately 1%. Tumors larger than 5 cm are associated with maternal and fetal complications. We report four cases of chorangioma that were identified in mostly primigravida (75%) with a mean gestational age of 33 wks (Range 28-33 wks). All except one case, complete placenta was received with mean weight of 550 g (Range 400-800 g) and tumor size of 9.4 cm (Range 0.5-23 cm). Microscopy showed capillary proliferation resembling fetal vessels in enlarged villi covered by trophoblastic epithelium. Three cases had preterm delivery. One also presented with abruptio placenta and intrauterine fetal death. Because of limited documentation of cases and dismal prognosis of these pregnancies, especially with large chorangiomas, it's of utmost importance to correctly diagnose them with the aid of color Doppler flow. In this series, 75% of cases (3/4), babies survived probably due to small size of tumor and attainment of fetal maturity.

Successful Pregnancy Outcome in a Case of Large Placental Chorangioma in an Elderly Primigravida

“…[3] The various factors linked with the pathogenesis include environmental factors like high altitude, hypoxic stimulus suggested by elevated nucleated red blood cells in the fetal circulation and vascular growth factors. [1] In most of the cases, chorangiomas are small or microscopic with no clinical significance. [2] Large chorangiomas are associated with adverse clinical outcome.…”

“…[1] They are also designated as placental angioma, chorionangioma, angiomyxoma and vascular hamartoma of placenta. [1] It is the most common benign tumour of placenta with an incidence of approximately 1% of all pregnancies. [2] Chorangiomas larger than 4 to 5 cm in diameter are associated with maternal and fetal complications.…”

Villous Capillary Lesions OfPlacentaA Ten-Year Experience With Brief Review Of Literature

“…Polyhydramnios, preterm labor IUGR, breech, NICU admission -CA with ischemic necrosis Andola et al, [26] 2014, n=4 23…”

“…[19] Table 4 highlights the associated complications of CA in various studies in the recent literature. [1,20,[22][23][24][25][26][27][28][29] The most common of these complications causing perinatal morbidity are polyhydramnios and preterm delivery, the later being the result of hydramnios. [19] The present study case of giant CA also had polyhydramnios with associated IUGR.…”

Giant Chorioangioma with Extraplacental PresentationA Rare Case Report

“…[5,6] Chorioangiomas can grossly be confused with degenerated myoma, subamniotic hematoma, placental teratoma and placental infarction. [7,8] So, a thorough histopathological examination and clinico-radiological correlation is necessary for identifying chorioangiomas.…”