Chondrosarcoma of the bones of the hand

Abstract

Nineteen chondrosarcomas are reported arising in proximal phalanges or metacarpal bones of the hand mainly in elderly patients, predominantly women. The usual clinical presentation was of a progressively painful large tumour, often arising in a dormant lesion near the metacarpo-phalangeal joint. Radiologically most showed some bone expansion with a poorly defined area of destruction and a considerable soft-tissue swelling. Histologically, malignancy was usually obvious, but confusion might arise from the inclusion of bland areas of chondromatous tissue that probably represented the original lesion. Four tumours, initially curetted and grafted, recurred locally and necessitated amputation of the digit or ray. Amputation was the primary treatment for fourteen other tumours and was curative except in one patient who eventually needed amputation through the forearm for a large second recurrence. One tumour was satisfactorily controlled by excision of the affected phalanx. None of these nineteen tumours is known to have metastasised. Correct treatment implies a carefully considered balance between conservation of function and complete removal of all tumour tissue.

Chondrosarcoma of the Hand: A Literature Review

“…The main symptom is progressive swelling, generallyassociated with pain [16] (Figure 2(a)). Many patients have symptoms for several years before being visited by a surgeon.…”

“…The main differential diagnosis is enchondroma; other possibilities are: ganglion, bursa, gout, rheumatoid arthritis, cyst, onychomatricoma and chondromyxoid fibroma (very rare in the hands) [16]. From a clinical point of view enchondroma could be easily distinguished from CS because the former rarely causes pain or swelling, except in case of fractures.…”

Study of Chondrosarcoma in Northwest Region of Libya

“…When comparing data with international reports, the age range was nearly equal to several studies that the neo-plasm has a wide age range, but most of the patients are in the second and third decades of life [14] and [7,23] who reported that Patients are usually between ages 20 and 40 years. In contrast to other studies that showed CS has a high incidence between the fourth and sixth decades of life [23][24][25], while others described that the majority of patients affected are over 50 years old [2,26]. However, Differences a cross epidemiological studies conducted in different parts of the world in incidence and frequency of age by decade of patients affected by CS may somewhat reflect or a representative of genetic background or a largely unknown risk factors.…”

“…These forms of chondromatosis are associated with somatic mutation in Isocitrate Dehydrogenase 1 (IDH1) gene and isocitrate dehydrogenase 2 (IDH2) gene [27]. Furthermore, the main symptom of CS is progressive swelling, generally associated with pain [24]. Many patients have symptoms for several years before being visited by a surgeon.…”

Chondrosarcoma of Metacarpal- A Rare Case Presentation

“…Chondrosarcoma is often separated into three histological grades: low (Grade 1), medium (Grade 2) and high (Grade 3). [3] The higher the grade, the more likely it is that the tumour will metastasise.…”