Chondroprotective Activity ofMurraya exoticathrough Inhibitingβ-Catenin Signaling Pathway

Wu, Longhuo; Liu, Haiqing; Zhang, Rui; Li, Linfu; Li, Jialin; Hu, Haibo; Huang, Hao

doi:10.1155/2013/752150

Cited by 8 publications

(9 citation statements)

References 31 publications

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“…The injection administration of resveratrol can significantly upregulate SIRT1 expression and downregulate the HIF-2 α expression, leading to suppression of iNOS and MMP-13 expression [ 110 ]. Our research group shows that Murraya exotica (L.) can dose-dependently downregulate the mRNA and protein expression of β -catenin and COX-2, inhibit the levels of TNF α and IL- β in synovial fluids, and decrease the chondrocytes apoptosis [ 111 ].…”

Section: Miscellaneousmentioning

confidence: 99%

Insights into the Action Mechanisms of Traditional Chinese Medicine in Osteoarthritis

Liu

Shi

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction, synovial inflammation, and osteophyte formation. No effective treatments are available. The current pharmacological medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics, accompanied by possible adverse effects, might ameliorate OA symptoms. But they do not arrest the progression of OA. Traditional Chinese medicine (TCM) provides medical value by modification of disease and symptoms in OA. Valuable work on exploring TCM merits for OA patients has been investigated using modern technologies, although the complicated interacting network among the numerous components indicates the uncertainty of target specification. This review will provide an overview of the action mechanism of TCM in the last 5 years, discussing the TCM activities of anti-inflammation, antiapoptosis, antioxidation, anticatabolism, and proliferation in OA. TCM is a proposed medical option for OA treatment.

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Section: Miscellaneousmentioning

confidence: 99%

Insights into the Action Mechanisms of Traditional Chinese Medicine in Osteoarthritis

Liu

Shi

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…Another study found that leaf extract of M exotica decreased chondrocyte apoptosis in a dose-dependent manner. 27 Although the plant extracts used in this study did not protect MDA-MB-231 cells from apoptosis, they did not cause much damage to the breast cancer cells. Studies have been conducted to demonstrate efficient cytotoxicity against tumor cells by coumarins from M exotica.…”

Section: Discussionmentioning

confidence: 66%

Promising Compounds FromMurraya exoticafor Cancer Metastasis Chemoprevention

Yang

Yan

et al. 2016

Integr Cancer Ther

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Most of the present anticancer drugs are highly cytotoxic and focus mainly on killing tumor cells rather than slowing the progress of cancer metastasis. Evidence has been reported that bridges the mechanisms of inflammation and tumor invasion. Therefore, we evaluated the potency in cancer metastasis chemoprevention of compounds and a coumarin extracted from Murraya exotica, which is known for its anti-inflammation bioactivity. By carrying out experiments in vitro, we found the root extracts more efficient than the leaf extracts in restraining cell migration of MDA-MB-231 cells, while leaf extracts presented slightly stronger inhibition of tumor cell adhesion at low concentrations. In addition, compared to root extracts, a novel coumarin identified previously from root extracts showed equal inhibition on cancer cell adhesion and less inhibition on cell migration. All extracts used in this study presented low cytotoxicity in vitro. Through comparison of the contents of leaf and root extracts from M exotica, several compounds are considered promising against cancer metastasis. This study evaluates the worth of further development of M exotica to find its effect on cancer metastasis chemoprevention.

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“…The nutrients found in the curry leaves are carbohydrates, fiber, calcium, iron, magnesium, copper, phosphorous, and minerals; and it also contains various vitamins like nicotinic acid and vitamin C, vitamin A, vitamin B, vitamin E, antioxidants, plant sterols, amino acids, glycosides, and flavonoids (Bonde, Nemade, Patel, & Patel, 2017). In India, people use the curry leaves as a flavoring agent in curries and usually which leads to the inflammation and necrosis in many pathological conditions (Dineshkumar, Mitra, & Mahadevappa, 2010;Ho et al, 2015;Paul, Bandyopadhyay, & Bhattacharyya, 2011;Wu et al, 2013). Likewise, similar condition was observed in pancreatitis.…”

Section: Discussionmentioning

confidence: 93%

“…The curry leaves exhibit potent antioxidant activity and anti‐inflammatory activity. The chemical constituents present in M. koeniggi are carbazole alkaloids, such as mahanimbine and koeiniggine, which shows antioxidant property by inhibiting the production of cytokines IL‐6 and IL‐1β by downregulation of NFκB, which leads to the inflammation and necrosis in many pathological conditions (Dineshkumar, Mitra, & Mahadevappa, ; Ho et al, ; Paul, Bandyopadhyay, & Bhattacharyya, ; Wu et al, ). Likewise, similar condition was observed in pancreatitis.…”

Section: Discussionmentioning

confidence: 99%

Modulation of cerulein‐induced pancreatic inflammation by hydroalcoholic extract of curry leaf (Murraya koenigii)

Khurana

Sikha

Ramesh

et al. 2019

Phytotherapy Research

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This study was performed to study the in vitro and in vivo efficacy of hydroalcoholic extract of curry leaf (CLE) rich in carbazole alkaloids, against LPS‐induced inflammation in Raw 264.7 macrophages and cerulein‐induced acute pancreatitis, respectively. CLE was characterized by Fourier‐transform infrared (FTIR) and liquid chromatography–mass spectrometry. Raw 264.7 cells were stimulated with LPS (2 μg/ml) and treated with CLE. The animals were treated with two doses of CLE (100 and 300 mg/kg). Plasma biochemistry, tissue lipid peroxidation, cytokines, and histological examination were evaluated. CLE was found to decently scavenge the activity of DPPH radical. It dose dependently suppressed nitrite production and oxidative stress in macrophages. CLE alleviated LPS‐induced inflammation in macrophages as evident from the results of various inflammatory cytokines (IL‐1β, IL‐6, and TNF‐α). In vivo, CLE reduced cerulein‐induced pancreatic edema. CLE significantly abrogated the cerulein‐induced lipid peroxidation, nitrite, MPO, and GSH levels. The inflammatory cytokines and p65‐NFκB activity were significantly reduced by CLE. Mechanistically, CLE reduced the expression of NT, MPO, IL‐1β, ICAM‐1, and COX‐2, and increased the expression of Nrf2. It reduced distant organ damage markers as well. We report for the first time that CLE holds substantial potential for the prevention of acute pancreatitis.

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Chondroprotective Activity ofMurraya exoticathrough Inhibitingβ-Catenin Signaling Pathway

Cited by 8 publications

References 31 publications

Insights into the Action Mechanisms of Traditional Chinese Medicine in Osteoarthritis

Insights into the Action Mechanisms of Traditional Chinese Medicine in Osteoarthritis

Promising Compounds FromMurraya exoticafor Cancer Metastasis Chemoprevention

Modulation of cerulein‐induced pancreatic inflammation by hydroalcoholic extract of curry leaf (Murraya koenigii)

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