Chondromyxoid Fibroma of Bone

Abstract

Abstract:Chondromyxoid fibroma (CMF) is a rare, benign and potentially aggressive cartilage forming bone tumour and accounts for less than 1% of primary bone tumour. It usually affects the metaphysis of long bones in first or second decades of life. It occurs in males more often than females. Because of rarity of CMF and its varied morphology, it can be confused with malignant tumour and adds difficulty in diagnosis. Herein, we report a case of CMF in a 32 year old female involving the proximal end of tibia.

Treatment of cryotherapy and orthotopic transplantation following chondromyxoid fibroma of zygomatic bone

“…Therapeutic treatment for CMF that have been reported include single excochleation, excochleation combined with cauterization of affected bone using phenol, [ 17 ] excochleation combined with phase I bone transplantation, and resection of the whole bone combined with phase I bone transplantation. [ 18 ] It is reported that application of single excochleation may reserve tumor cells, thus leading to 80% of tumor recurrence rate.…”

Chondromyxoid Fibroma: A Rare Case Report and Review of Literature

“…The typical histological features of CMF are a lobular pattern with stellate-shaped cells in a myxoid or chondroid background with hypocellular centres and hypercellular peripheries. Osteoclast-like giant cells are often present at the lobular peripheries [8]. Dahlin stressed that giant cells at the periphery of the chondroid lobules with plump hyperchromatic nuclei with nuclear atypism are characteristic of CMF [9].…”

“…Similar features were seen in our case. The differential diagnosis of CMF includes chondroblastoma, chondrosarcoma, enchondroma, and aneurysmal bone cyst, but it is the salient histological features that distinguish these lesions [8]. …”

“…The treatment options of CMF include simple curettage, curettage with phenol application, and en bloc resection with bone grafting [8]. The tendency to local recurrence after initial curettage seems to be even higher in young children, i.e.…”

“…The tendency to local recurrence after initial curettage seems to be even higher in young children, i.e. 80% [8]. But curettage with phenol application followed by bone grafting has a very low rate of recurrence of seven percent [7].…”