Treatment of cryotherapy and orthotopic transplantation following chondromyxoid fibroma of zygomatic bone

Abstract

Introduction:Chondromyxoid fibrotherma (CMF) is a rare benign cartilage tumor that occurs more frequently in young males at the age of 20 to 30. It occurs more frequently on long bones, but rarely involves craniofacial bones.Case presentation:This study mainly introduced a 30-year-old male with CMF of zygomatic bone. Single tumor excochleation was conducted initially. However, CMF reoccurred, and then the following steps were adopted: firstly, the tumor was extensively excised; secondly, in vitro tumor excochleation was conducted; thirdly, the excised tumor bone was placed in liquid nitrogen for 3 cycles of cryoablation; finally, the orthotopic transplantation was performed to reconstruct the zygomatic appearance, with satisfactory follow-up efficacy obtained.Conclusions:Orthotopic transplantation after tumorectomy and cryopreservation of tumor bone in liquid nitrogen could lead to excellent therapeutic efficacy and deserves to be widely applied in clinical practice in the treatment of a male patient with CMF of zygomatic bone, because it not only radically eliminates the tumor and kills tumor cells, but also provides bony skeleton for the growth of new bone, thus greatly promoting postoperative aesthetic degree and reducing the occurrence rates of complications.

Chondromyxoid fibroma of zygomatic bone: A case report

“…CF is a rare bone tumor and represents less than 1% of all bone tumors, the tibia and distal femur are the most frequent locations, the maxillofacial bones are rarely affected, with the mandible as a site of predilection [ 1 ], the zygomatic location is extremely rare with only eight cases reported in litterature to our knowledge [ [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] ].…”

“…In this case we report a rare presentation of chondromyxoid fibroma involving the zygomatic bone, to our knowledge only 8 cases of zygomatic CMF have been reported in the literature [ [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] ].…”

Reconstruction using a frozen autograft for a skull and humeral lesion of synchronous multicentric osteosarcoma after undergoing successful neoadjuvant chemotherapy: a case report and review of the literature

“…Synthetic or plate reconstruction after tumor excision is generally performed to protect the brain and fill bone defects, but there are sometimes cosmetic issues, and the complications, such as infection, or motor impairment due to brain damage, cannot be denied. Tumor excision of skull lesions and reconstruction using a frozen autograft treated with liquid nitrogen have been rarely reported [ 26 – 28 ]. However, this cryotherapy treatment and orthotopic transplantation method not only eliminates the tumor cells, but it also provides for bone filling which perfectly matches the same size as the bone defect, while also reducing the incidence rates of complications [ 19 , 20 , 26 – 28 ].…”

“…Tumor excision of skull lesions and reconstruction using a frozen autograft treated with liquid nitrogen have been rarely reported [ 26 – 28 ]. However, this cryotherapy treatment and orthotopic transplantation method not only eliminates the tumor cells, but it also provides for bone filling which perfectly matches the same size as the bone defect, while also reducing the incidence rates of complications [ 19 , 20 , 26 – 28 ]. The good histological efficacy of neoadjuvant chemotherapy for the primary lesion was observed in our case; thus, reconstruction using a frozen autograft treated with liquid nitrogen after tumor excision with a clear margin, was applied.…”