Chondroitin Sulfate-Linked Prodrug Nanoparticles Target the Golgi Apparatus for Cancer Metastasis Treatment

Li, Haohuan; Zhang, Pei; Luo, Jingwen; Hu, Danrong; Huang, Yuan; Zhang, Zhirong; Fu, Yao; Gong, Tao

doi:10.1021/acsnano.9b04166

Cited by 115 publications

(87 citation statements)

References 55 publications

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“…Another research team developed a prodrug nanoparticle system, which appeared to target the Golgi apparatus and realized retinoic acid release under an acidic environment. The retinoic acid-conjugated chondroitin sulfate could reduce the expression of metastasis-associated proteins by inducing Golgi fragmentation (163). Those findings suggest that the Golgi apparatus is a promising target for the development of novel drugs.…”

Section: Clinical Value Of Golgi Apparatusmentioning

confidence: 86%

The role of the Golgi apparatus in disease (Review)

Liu

Huang

et al. 2021

Int J Mol Med

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The Golgi apparatus is known to underpin many important cellular homeostatic functions, including trafficking, sorting and modifications of proteins or lipids. These functions are dysregulated in neurodegenerative diseases, cancer, infectious diseases and cardiovascular diseases, and the number of disease-related genes associated with Golgi apparatus is on the increase. Recently, many studies have suggested that the mutations in the genes encoding Golgi resident proteins can trigger the occurrence of diseases. By summarizing the pathogenesis of these genetic diseases, it was found that most of these diseases have defects in membrane trafficking. Such defects typically result in mislocalization of proteins, impaired glycosylation of proteins, and the accumulation of undegraded proteins. In the present review, we aim to understand the patterns of mutations in the genes encoding Golgi resident proteins and decipher the interplay between Golgi resident proteins and membrane trafficking pathway in cells. Furthermore, the detection of Golgi resident protein in human serum samples has the potential to be used as a diagnostic tool for diseases, and its central role in membrane trafficking pathways provides possible targets for disease therapy. Thus, we also introduced the clinical value of Golgi apparatus in the present review.

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Section: Clinical Value Of Golgi Apparatusmentioning

confidence: 86%

The role of the Golgi apparatus in disease (Review)

Liu

Huang

et al. 2021

Int J Mol Med

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“…In this framework, the organic material-based nanoparticles, usually the socalled biodegradable polymers (Poly-L-lactide, PLA), 81 can be designed by a kind or more of monomers linked by various sensitive ionizable weakly acidic and basic linkages (polymers from natural origin, dextran and chitosan and synthetic origin that possessing acid and amine functional groups), 82 as well as specific molecular switches, such as disulfide, hydrazone, dinitroimidazole-based linkages. 81,[83][84][85][86] In fact, these molecules are highly responsive to the acidic environment and can significantly facilitate the degradation of the construct. 87,88 To this end, some of the inorganic nanoparticles, such as metalorganic frameworks (MOFs), periodic mesoporous silicas (PMOs), and other stable nanoparticles such as gold and platinum nanoparticles, that are immobilized with acid-responsive linkages can be degradable in the endosomal/lysosomal microenvironment, resulting in the small-sized nanocrystals or even free ions.…”

Section: Degradabilitymentioning

confidence: 99%

<p>Subcellular Performance of Nanoparticles in Cancer Therapy</p>

Liu

Han

Kankala

et al. 2020

IJN

113

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With the advent of nanotechnology, various modes of traditional treatment strategies have been transformed extensively owing to the advantageous morphological, physiochemical, and functional attributes of nano-sized materials, which are of particular interest in diverse biomedical applications, such as diagnostics, sensing, imaging, and drug delivery. Despite their success in delivering therapeutic agents, several traditional nanocarriers often end up with deprived selectivity and undesired therapeutic outcome, which significantly limit their clinical applicability. Further advancements in terms of improved selectivity to exhibit desired therapeutic outcome toward ablating cancer cells have been predominantly made focusing on the precise entry of nanoparticles into tumor cells via targeting ligands, and subsequent delivery of therapeutic cargo in response to specific biological or external stimuli. However, there is enough room intracellularly, where diverse small-sized nanomaterials can accumulate and significantly exert potentially specific mechanisms of antitumor effects toward activation of precise cancer cell death pathways that can be explored. In this review, we aim to summarize the intracellular pathways of nanoparticles, highlighting the principles and state of their destructive effects in the subcellular structures as well as the current limitations of conventional therapeutic approaches. Next, we give an overview of subcellular performances and the fate of internalized nanoparticles under various organelle circumstances, particularly endosome or lysosome, mitochondria, nucleus, endoplasmic reticulum, and Golgi apparatus, by comprehensively emphasizing the unique mechanisms with a series of interesting reports. Moreover, intracellular transformation of the internalized nanoparticles, prominent outcome and potential affluence of these interdependent subcellular components in cancer therapy are emphasized. Finally, we conclude with perspectives with a focus on the contemporary challenges in their clinical applicability.

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“…[ 7,8 ] To improve the targeting potential of the anticancer drugs, nanoparticles have been heavily studied in drug loading and targeted delivery on cancer metastasis. [ 9–13 ] Generally, drug‐loaded nanoparticles need to be optimized for the size control and surface modification to enhance their retention time and targeting efficiency. [ 14–18 ] However, the feasibility of these nanoparticles in vivo is limited by several restrictions, such as high production costs, technical challenges, and poor metabolism in the body.…”

Section: Figurementioning

confidence: 99%

Biodegradable Microalgae‐Based Carriers for Targeted Delivery and Imaging‐Guided Therapy toward Lung Metastasis of Breast Cancer

Zhong

Zhang

Xie

et al. 2020

Small

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High delivery efficiency, prolonged drug release, and low systemic toxicity are effective weapons for drug delivery systems to win the battle against metastatic breast cancer. Herein, it is shown that Spirulina platensis (S. platensis) can be used as natural carriers to construct a drug‐loaded system for targeted delivery and fluorescence imaging‐guided chemotherapy on lung metastasis of breast cancer. The chemotherapeutic doxorubicin (DOX) is loaded into S. platensis (SP) via only one facile step to fabricate the DOX‐loaded SP (SP@DOX), which exhibits ultrahigh drug loading efficiency and PH‐responsive drug sustained release. The rich chlorophyll endows SP@DOX excellent fluorescence imaging capability for noninvasive tracking and real‐time monitoring in vivo. Moreover, the micrometer‐sized and spiral‐shaped SP carriers enable the as‐prepared SP@DOX to passively target the lungs and result in a significantly enhanced therapeutic efficacy on lung metastasis of 4T1 breast cancer. Finally, the undelivered carriers can be biodegraded through renal clearance without notable toxicity. The SP@DOX described here presents a novel biohybrid strategy for targeted drug delivery and effective treatment on cancer metastasis.

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Chondroitin Sulfate-Linked Prodrug Nanoparticles Target the Golgi Apparatus for Cancer Metastasis Treatment

Cited by 115 publications

References 55 publications

The role of the Golgi apparatus in disease (Review)

The role of the Golgi apparatus in disease (Review)

<p>Subcellular Performance of Nanoparticles in Cancer Therapy</p>

Biodegradable Microalgae‐Based Carriers for Targeted Delivery and Imaging‐Guided Therapy toward Lung Metastasis of Breast Cancer

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