Chondroitin Sulfate-Induced Generation of Epiretinal Membranes

Russell, Stephen R.; Hageman, Gregory S.

doi:10.1001/archopht.1992.01080190106037

Cited by 11 publications

(3 citation statements)

References 38 publications

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“…In most cases, however, ERMs occur independently of these specific diseases and are termed "idiopathic" [14]. The pathogenesis of idiopathic ERMs has been explored in detailed histopathologic and immunohistochemical studies [6,9,20] but is still tentative. In most cases, ERMs have small or no effect on vision, although in some cases membrane contraction may exert tangential traction on the macular retina, causing severe vision loss [22]; therefore, it is crucial to identify the risk factors for idiopathic ERMs to enhance understanding of the disease.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors for epiretinal membranes in a Japanese population: the Hisayama study

Miyazaki

Nakamura

Kubo

et al. 2003

Graefe's Arch Clin Exp Ophthalmol

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Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors for epiretinal membranes in a Japanese population: the Hisayama study

Miyazaki

Nakamura

Kubo

et al. 2003

Graefe's Arch Clin Exp Ophthalmol

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“…14 The strong adhesion at the vitreous base and the papillary margin is mediated by chondroitin sulfate glycosaminoglycan. 15 Foos published an autopsy study in 1973 16 demonstrating that the visible Vogt or Weiss ring had components of avulsed peripapillary glial tissue in every case demonstrating the tenacity of this adhesion. It follows that separation from the papillary margin would be the final step in PVD.…”

Section: Discussionmentioning

confidence: 99%

Clinically Relevant Posterior Vitreous Detachment Staging Using Circumpapillary and Macular Volume Optical Coherence Tomography

Brown,

Laswell,

Rahman

et al. 2024

Retina

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Purpose: This study was designed to investigate retinal nerve fiber layer (RNFL) circumpapillary optical coherence tomography (C-OCT) to determine posterior vitreous detachment (PVD) status and to develop a clinically relevant PVD grading scale based on RNFL C-OCT to determine the incidence of PVD by age and association with vitreomacular traction disorders. Methods: Ophthalmic images and medical records of retina patients were retrospectively analyzed by three masked graders using RNFL C-OCT and macular OCT (M-OCT). Based on PVD status, eyes were categorized into five newly defined PVD stages. Results: Among 2002 eyes, PVD stages were: A) 25 (1.25%); B) 725 (36.21%); C-) 248 (12.39%); C+) 151 (7.54%); D) 851 (42.51%); X) 2 (0.1%). PVD was correlated with advanced age (P<<0.0001). Limited separation or partial separation between lamella within the posterior vitreous cortex (stage B) was noted early (68% of eyes <18 years). 34% of eyes >70 years did not exhibit complete PVD. Of 75 eyes with tractional vitreoretinal disorders, 64 (85.3%) were stage C-/C+, identifying stage C as the high risk “complication” stage. Conclusion: Imaging analyses using RNFL C-OCT and M-OCT scans in conjunction allows rapid assessment of PVD stage. These techniques can assist clinicians and surgeons in counseling patients and planning surgical approach. Observations confirmed progression of PVD through predictable stages and progression of PVD with age.

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“…GAG constituents of ERMs are a completely uncharted territory. Interestingly, intravitreal injection of chondroitin-6-sulfate triggers the development of experimental ERMs [ 57 ]. One might expect that this finding should have prompted researchers to investigate GAG composition of ERMs, either idiopathic or secondary.…”

Section: Ecm Components Of Iermsmentioning

confidence: 99%

Untangling the Extracellular Matrix of Idiopathic Epiretinal Membrane: A Path Winding among Structure, Interactomics and Translational Medicine

Bianchi

Altera

Barone

et al. 2022

Cells

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Idiopathic epiretinal membranes (iERMs) are fibrocellular sheets of tissue that develop at the vitreoretinal interface. The iERMs consist of cells and an extracellular matrix (ECM) formed by a complex array of structural proteins and a large number of proteins that regulate cell–matrix interaction, matrix deposition and remodelling. Many components of the ECM tend to produce a layered pattern that can influence the tractional properties of the membranes. We applied a bioinformatics approach on a list of proteins previously identified with an MS-based proteomic analysis on samples of iERM to report the interactome of some key proteins. The performed pathway analysis highlights interactions occurring among ECM molecules, their cell receptors and intra- or extracellular proteins that may play a role in matrix biology in this special context. In particular, integrin β1, cathepsin B, epidermal growth factor receptor, protein-glutamine gamma-glutamyltransferase 2 and prolow-density lipoprotein receptor-related protein 1 are key hubs in the outlined protein–protein cross-talks. A section on the biomarkers that can be found in the vitreous humor of patients affected by iERM and that can modulate matrix deposition is also presented. Finally, translational medicine in iERM treatment has been summed up taking stock of the techniques that have been proposed for pharmacologic vitreolysis.

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Chondroitin Sulfate-Induced Generation of Epiretinal Membranes

Cited by 11 publications

References 38 publications

Prevalence and risk factors for epiretinal membranes in a Japanese population: the Hisayama study

Prevalence and risk factors for epiretinal membranes in a Japanese population: the Hisayama study

Clinically Relevant Posterior Vitreous Detachment Staging Using Circumpapillary and Macular Volume Optical Coherence Tomography

Untangling the Extracellular Matrix of Idiopathic Epiretinal Membrane: A Path Winding among Structure, Interactomics and Translational Medicine

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