Chondroitin Sulfate in Palatal Wound Healing

Abstract

Chondroitin sulfate is up-regulated in granulation tissue during wound healing. To investigate the role of chondroitin sulfate in the wound-healing process after surgical repair of cleft palate, we isolated and cultured rabbit palatal fibroblasts. Treatment with chondroitin-6-sulfate resulted in a dose-dependent increase in cell adhesion and cell proliferation, whereas the reverse effects were seen after chondroitinase degradation of chondroitin sulfate. The biological actions of chondroitin sulfate appeared to be dependent on the presence and position of sulfate groups. Inhibition of glycosaminoglycan sulfation by chlorate treatment led to reduced cell adhesion and cell proliferation and a slower rate of wound closure in vitro. Furthermore, exposure to chondroitin-4-sulfate resulted in a dose-dependent reduction in cell adhesion. Together, these results show that chondroitin sulfate is involved in palatal wound healing.

Increased expression of non-sulfated chondroitin correlates with adverse clinicopathological parameters in prostate cancer

“…19,20 The biological activities of chondroitin sulfate, as well as its ability to bind to and interact with different growth factors and signaling molecules, are dependent on the presence of distinct sulfation motifs. [21][22][23] However, recent studies suggest that non-sulfated chondroitin is also biologically active and is essential for cell division. 22,24 Thus, we aimed to determine the expression pattern of this molecule in prostate cancer by immunohistochemistry using 1B5, a monoclonal antibody with established specificity for non-sulfated chondroitin.…”

Isolation and Characterization of Chondroitin Sulfates from Sturgeon (<i>Acipenser sinensis</i>) and Their Effects on Growth of Fibroblasts

“…It also helps to regulate cell adhesion and enhance cell spreading and migration. 7,14,15) Sturgeon (Acipenser sinensis) is a globally important wildlife resource that contributes as an important element of local food supply. 16) Sturgeon's cartilage contains biologically active substances such as collagen, glucosamine, and CS.…”

“…5) In addition, CS plays important roles in the elasticity, function of the articular cartilage, wound healing, the central nervous system, and chondrocytes. [6][7][8][9][10] Wound healing is a complex process that is a result of mechanical and chemical injuries. It has been divided into three main phases: inflammation, proliferation and tissue remodeling.…”

Modulation of FGF2 after topical application of Stichopus hermanii gel on traumatic ulcer in Wistar rats

“…10 In addition to HA, Stichopus hermanii also contain chondroitin sulphate, heparin sulphate and dermatan sulphate which have the ability to activate and bind to GF specially FGF2. 11,12 Unsaturated fatty acids also found as content in Stichopus hermanii are key mediators to control inflammation process in wound healing, arranging fibroblast proliferation and collagen synthesis to produce healthy collagen. Another advantage of the presence of this unsaturated fatty acid is to minimalize the scar formation and increase the strength of connective tissue.…”