Chondrocyte Signaling and Artificial Matrices for Articular Cartilage Engineering

Yoon, Diana M.; Fisher, John P.

doi:10.1007/978-0-387-34133-0_5

Cited by 49 publications

(43 citation statements)

References 111 publications

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“…This is similar to the increased apoptosis seen in transgenic mice lacking Col II (Yang et al, 1997). The absence of a proper cartilage could hinder not only the supply of nutrients to the avascular ECM (Hunziker and Herrmann, 1990) but also have profound effects on integrin-mediated pathways and distribution of growth factors (Yoon and Fisher, 2006). The inability to extract normal amounts of full-length Col II from cartilage, the decreased birefringence of Col II network, the lack of the Col IIB lattice network, and the considerable reduction in collagen fi brillar density as seen by electron microscopy all attest to the fact that the cartilage is abnormal in S1P cko mice.…”

Section: Discussionmentioning

confidence: 53%

Site-1 protease is essential for endochondral bone formation in mice

Patra¹,

Davies²,

Bryan³

et al. 2007

J Exp Med

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Abbreviations used in this paper: Agc1, aggrecan; ATF6, activating transcription factor 6; BiP, immunoglobulin heavy chain binding protein; BSP, bone sialoprotein; Col I, type I collagen; CREBH, cAMP-responsive element binding protein H; E, embryonic day; ERSS, ER stress signaling; IHC, immunohistochemistry; Ihh, Indian hedgehog; MMP, matrix metalloproteinase; OASIS, old astrocyte specifi cally induced substance; PECAM-1, platelet/endothelial cell adhesion molecule 1; Ptc-1, Patched-1; PTHrP, parathyroid hormone-related peptide; S1P, site-1 protease; SCAP, SREBP cleavage-activating protein; SREBP, sterol regulatory element binding protein; WT, wild type.The online version of this article contains supplemental material.

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Section: Discussionmentioning

confidence: 53%

Site-1 protease is essential for endochondral bone formation in mice

Patra¹,

Davies²,

Bryan³

et al. 2007

J Exp Med

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“…13,14,50,56,57 In addition, chondrogenic growth factors play a key role in chondrocyte differentiation and cartilage generation. 58 The most challenging aspect of cartilage tissue engineering is to replicate the natural compressive behavior of cartilage under mechanical loading conditions and its porous structure for cell nutrients. Mechanical stimulations in the form of dynamic compression and hydrostatic pressure have been found to be effective in promoting chondrogenic differentiation of stem cells and chondrocytes; however, results are mixed for other types of mechanical stimulation.…”

Section: Cartilage Tissue Engineeringmentioning

confidence: 99%

Monitoring Cartilage Tissue Engineering Using Magnetic Resonance Spectroscopy, Imaging, and Elastography

Kotecha

Klatt

Magin

2013

Tissue Engineering Part B: Reviews

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A key technical challenge in cartilage tissue engineering is the development of a noninvasive method for monitoring the composition, structure, and function of the tissue at different growth stages. Due to its noninvasive, three-dimensional imaging capabilities and the breadth of available contrast mechanisms, magnetic resonance imaging (MRI) techniques can be expected to play a leading role in assessing engineered cartilage. In this review, we describe the new MR-based tools (spectroscopy, imaging, and elastography) that can provide quantitative biomarkers for cartilage tissue development both in vitro and in vivo. Magnetic resonance spectroscopy can identify the changing molecular structure and alternations in the conformation of major macromolecules (collagen and proteoglycans) using parameters such as chemical shift, relaxation rates, and magnetic spin couplings. MRI provides high-resolution images whose contrast reflects developing tissue microstructure and porosity through changes in local relaxation times and the apparent diffusion coefficient. Magnetic resonance elastography uses low-frequency mechanical vibrations in conjunction with MRI to measure soft tissue mechanical properties (shear modulus and viscosity). When combined, these three techniques provide a noninvasive, multiscale window for characterizing cartilage tissue growth at all stages of tissue development, from the initial cell seeding of scaffolds to the development of the extracellular matrix during construct incubation, and finally, to the postimplantation assessment of tissue integration in animals and patients.

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“…Hydrogels are typically biocompatible, owing to their large water content, as they do not provoke an immune response and cause inflammation. Thus, hydrogels have been found to possess tissue-like properties as they can be successfully used to encapsulate cells and create a cellscaffold environment (36,37). Hydrogels can also be used in an injectable form to repair irregular shaped defects and for cosmetic surgery.…”

Section: Types Of Scaffoldsmentioning

confidence: 99%

Biomaterial Scaffolds in Pediatric Tissue Engineering

Patel

Fisher

2008

Pediatr Res

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This article reviews recent developments and major issues in the use and design of biomaterials for use as scaffolds in pediatric tissue engineering. A brief history of tissue engineering and the limitations of current tissue-engineering research with respect to pediatric patients have been introduced. An overview of the characteristics of an ideal tissue-engineering scaffold for pediatric applications has been presented, including a description of the different types of scaffolds. Applications of scaffolds materials have been highlighted in the fields of drug delivery, bone, cardiovascular, and skin tissue engineering with respect to the pediatric population. This review highlights biomaterials as scaffolds as an alternative treatment method for pediatric surgeries due to the ability to create a functional cell-scaffold environment.

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Chondrocyte Signaling and Artificial Matrices for Articular Cartilage Engineering

Cited by 49 publications

References 111 publications

Site-1 protease is essential for endochondral bone formation in mice

Site-1 protease is essential for endochondral bone formation in mice

Monitoring Cartilage Tissue Engineering Using Magnetic Resonance Spectroscopy, Imaging, and Elastography

Biomaterial Scaffolds in Pediatric Tissue Engineering

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