Biomaterial Scaffolds in Pediatric Tissue Engineering

Patel, Minal; Fisher, James

doi:10.1203/01.pdr.0b013e318165eb3e

Cited by 85 publications

(67 citation statements)

References 53 publications

(39 reference statements)

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“…Successful production of cartilage, bone and dental grafts remains a challenge in tissue engineering [1,2]. Moreover, inappropriate mineralization is a common pathological occurrence, arguing a need for novel therapeutic approaches for its prevention [3].…”

Section: Introductionmentioning

confidence: 99%

Contrasts between organic participation in apatite biomineralization in brachiopod shell and vertebrate bone identified by nuclear magnetic resonance spectroscopy

Neary

Reid

Mason

et al. 2010

J. R. Soc. Interface.

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Unusually for invertebrates, linguliform brachiopods employ calcium phosphate mineral in hard tissue formation, in common with the evolutionarily distant vertebrates. Using solidstate nuclear magnetic resonance spectroscopy (SSNMR) and X-ray powder diffraction, we compare the organic constitution, crystallinity and organic matrix -mineral interface of phosphatic brachiopod shells with those of vertebrate bone. In particular, the organic -mineral interfaces crucial for the stability and properties of biomineral were probed with SSNMR rotational echo double resonance (REDOR). Lingula anatina and Discinisca tenuis shell materials yield strikingly dissimilar SSNMR spectra, arguing for quite different organic constitutions. However, their fluoroapatite-like mineral is highly crystalline, unlike the poorly ordered hydroxyapatite of bone. Neither shell material shows 13 Cf 31 Pg REDOR effects, excluding strong physico-chemical interactions between mineral and organic matrix, unlike bone in which glycosaminoglycans and proteins are composited with mineral at sub-nanometre length scales. Differences between organic matrix of shell material from L. anatina and D. tenuis, and bone reflect evolutionary pressures from contrasting habitats and structural purposes. The absence of organic -mineral intermolecular associations in brachiopod shell argues that biomineralization follows different mechanistic pathways to bone; their details hold clues to the molecular structural evolution of phosphatic biominerals, and may provide insights into novel composite design.

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Section: Introductionmentioning

confidence: 99%

Contrasts between organic participation in apatite biomineralization in brachiopod shell and vertebrate bone identified by nuclear magnetic resonance spectroscopy

Neary

Reid

Mason

et al. 2010

J. R. Soc. Interface.

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“…52 Despite acceptable results in epithelialization of keratinocytes with synthetic polymers, no successful epidermal graft has been achieved, due to their limited cellular recognition and tissue compatibility. Synthetic polymers in combination with natural polymers can be used for temporary dressing, epidermal/dermal cell carriers, or full-thickness skin equivalent, 53 PLGA/collagen, 54 PLA/ chitosan, 55 PCL/chitosan, 56 PCL/collagen 57 currently used for skin graft development.…”

Section: Tissue Engineering Selected Applicationmentioning

confidence: 99%

Tissue Engineering: Challenges and Selected Application

Pogorielov¹,

Oleks²,

Oleshko³

et al. 2017

ATROA

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Tissue engineering has become a promising strategy for repairing damaged organs and tissues. Favorable government regulatory framework, continuous technology advancements and increasing research funding drive the market for alternative regenerative medicine therapies. Current mini-review coverskey components needed for tissue engineering -cells, scaffold and growth factors as well as method for tissue engineering graft manufacturing. Selected applications -for bone, skin and peripheral nerve regeneration are highlight in the paper.

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“…The degradation pattern of a scaffold should occur at an appropriate pace specific to the host tissue; for example, degradation occurring within 3 to 6 mo would be acceptable in the craniofacial skeleton, where there is lower mechanical demand, but inappropriate following spinal fusion (Bose et al, 2012). The ability of the scaffold to fully resorb and remodel completely is especially important for pediatric craniofacial applications, where the skull must be able to develop and mature during normal growth of the immature pediatric skeleton (Patel and Fisher, 2008;Ricci et al, 2012). porosity Interconnected porosity is another key factor in scaffold design.…”

Section: Natural and Synthetic Polymersmentioning

confidence: 99%

Biomaterials for Craniofacial Bone Engineering

et al. 2014

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Conditions such as congenital anomalies, cancers, and trauma can all result in devastating deficits of bone in the craniofacial skeleton. This can lead to significant alteration in function and appearance that may have significant implications for patients. In addition, large bone defects in this area can pose serious clinical dilemmas, which prove difficult to remedy, even with current gold standard surgical treatments. The craniofacial skeleton is complex and serves important functional demands. The necessity to develop new approaches for craniofacial reconstruction arises from the fact that traditional therapeutic modalities, such as autologous bone grafting, present myriad limitations and carry with them the potential for significant complications. While the optimal bone construct for tissue regeneration remains to be elucidated, much progress has been made in the past decade. Advances in tissue engineering have led to innovative scaffold design, complemented by progress in the understanding of stem cell-based therapy and growth factor enhancement of the healing cascade. This review focuses on the role of biomaterials for craniofacial bone engineering, highlighting key advances in scaffold design and development.

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Biomaterial Scaffolds in Pediatric Tissue Engineering

Cited by 85 publications

References 53 publications

Contrasts between organic participation in apatite biomineralization in brachiopod shell and vertebrate bone identified by nuclear magnetic resonance spectroscopy

Contrasts between organic participation in apatite biomineralization in brachiopod shell and vertebrate bone identified by nuclear magnetic resonance spectroscopy

Tissue Engineering: Challenges and Selected Application

Biomaterials for Craniofacial Bone Engineering

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