Tissue Engineering: Challenges and Selected Application

Pogorielov, Мaksym; Oleks,; Oleshko, r; Hapchenko, Andrii

doi:10.15406/atroa.2017.03.00058

Cited by 4 publications

(6 citation statements)

References 59 publications

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“…A plausible explanation for this leading role of Twitter in the diffusion of TE information is that the development of TE has taken place in parallel with the burst of social media. Probably, as previously stated for other scientific disciplines, TE researchers have substituted the idea of academic community for the virtual department [ 74 , 75 ]. Moreover, the structural multidisciplinary nature of TE and the relationships between the biomaterials industry, research groups, and clinicians can be ideally displayed using a social network such as Twitter [ 10 , 58 , 76 ].…”

Section: Discussionmentioning

confidence: 99%

Information and Scientific Impact of Advanced Therapies in the Age of Mass Media: Altmetrics-Based Analysis of Tissue Engineering

Santisteban‐Espejo¹,

Martín-Piedra²,

Campos³

et al. 2021

J Med Internet Res

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Background Tissue engineering (TE) constitutes a multidisciplinary field aiming to construct artificial tissues to regenerate end-stage organs. Its development has taken place since the last decade of the 20th century, entailing a clinical revolution. TE research groups have worked and shared relevant information in the mass media era. Thus, it would be interesting to study the online dimension of TE research and to compare it with traditional measures of scientific impact. Objective The objective of this study was to evaluate the online dimension of TE documents from 2012 to 2018 using metadata obtained from the Web of Science (WoS) and Altmetric and to develop a prediction equation for the impact of TE documents from altmetric scores. Methods We analyzed 10,112 TE documents through descriptive and statistical methods. First, the TE temporal evolution was exposed for WoS and 15 online platforms (news, blogs, policy, Twitter, patents, peer review, Weibo, Facebook, Wikipedia, Google, Reddit, F1000, Q&A, video, and Mendeley Readers). The 10 most cited TE original articles were ranked according to the normalized WoS citations and the normalized Altmetric Attention Score. Second, to better comprehend the TE online framework, correlation and factor analyses were performed based on the suitable results previously obtained for the Bartlett sphericity and Kaiser–Meyer–Olkin tests. Finally, the linear regression model was applied to elucidate the relation between academics and online media and to construct a prediction equation for TE from altmetrics data. Results TE dynamic shows an upward trend in WoS citations, Twitter, Mendeley Readers, and Altmetric Scores. However, WoS and Altmetric rankings for the most cited documents clearly differ. When compared, the best correlation results were obtained for Mendeley Readers and WoS (ρ=0.71). In addition, the factor analysis identified 6 factors that could explain the previously observed differences between academic institutions and the online platforms evaluated. At this point, the mathematical model constructed is able to predict and explain more than 40% of TE WoS citations from Altmetric scores. Conclusions Scientific information related to the construction of bioartificial tissues increasingly reaches society through different online media. Because the focus of TE research importantly differs when the academic institutions and online platforms are compared, basic and clinical research groups, academic institutions, and health politicians should make a coordinated effort toward the design and implementation of adequate strategies for information diffusion and population health education.

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Section: Discussionmentioning

confidence: 99%

Information and Scientific Impact of Advanced Therapies in the Age of Mass Media: Altmetrics-Based Analysis of Tissue Engineering

Santisteban‐Espejo¹,

Martín-Piedra²,

Campos³

et al. 2021

J Med Internet Res

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“…[57,58]. However, these structures have shown several limitations, the most important being reduced cell viability and the lack of 3D inter-cellular connections similar to living tissues, which determined the formation of unwanted necrotic cores [3].…”

Section: Laser Assisted Fabrication Methodsmentioning

confidence: 99%

“…The design and fabrication of 3D structures at micro-and nanoscale represent a continuous challenge for biomedical applications such as tissue engineering [1][2][3], controlled drug delivery [4], cell biology [5][6][7][8] and biomimetics [9,10]. There are several fabrication approaches that initially provided reasonable results, but each of their advantages has been counterbalanced by at least one drawback.…”

Section: Introductionmentioning

confidence: 99%

“…Further progress has been achieved through the fabrication of stimuli-responsive 3D structures of length scales ranging from micro-to nanometers, having complex and reproducible geometries. Such structures have been fabricated by a wide variety of techniques and proved a high efficiency for biomedical applications [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Recently, the fabrication of stimuli-responsive 3D micro/nanostructures using laser-assisted protocols emerged as a powerful tool able to surmount the drawbacks of other technologies [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Review on Stimuli-Actuated 3D Micro/Nanostructures for Tissue Engineering and the Potential of Laser-Direct Writing via Two-Photon Polymerization for Structure Fabrication

Călin

Păun

2022

IJMS

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In this review, we present the most recent and relevant research that has been done regarding the fabrication of 3D micro/nanostructures for tissue engineering applications. First, we make an overview of 3D micro/nanostructures that act as backbone constructs where the seeded cells can attach, proliferate and differentiate towards the formation of new tissue. Then, we describe the fabrication of 3D micro/nanostructures that are able to control the cellular processes leading to faster tissue regeneration, by actuation using topographical, mechanical, chemical, electric or magnetic stimuli. An in-depth analysis of the actuation of the 3D micro/nanostructures using each of the above-mentioned stimuli for controlling the behavior of the seeded cells is provided. For each type of stimulus, a particular recent application is presented and discussed, such as controlling the cell proliferation and avoiding the formation of a necrotic core (topographic stimulation), controlling the cell adhesion (nanostructuring), supporting the cell differentiation via nuclei deformation (mechanical stimulation), improving the osteogenesis (chemical and magnetic stimulation), controlled drug-delivery systems (electric stimulation) and fastening tissue formation (magnetic stimulation). The existing techniques used for the fabrication of such stimuli-actuated 3D micro/nanostructures, are briefly summarized. Special attention is dedicated to structures’ fabrication using laser-assisted technologies. The performances of stimuli-actuated 3D micro/nanostructures fabricated by laser-direct writing via two-photon polymerization are particularly emphasized.

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“…The majority of cell-based skin substitutes are comprised of a scaffold upon which cells are seeded/cultured. Scaffolds are designed to integrate into the host tissue and provide an appropriate environment for cell growth, infiltration, and differentiation [26]. Thus, those scaffolds need to exhibit some specific characteristics such as appropriate porosity distribution to deliver oxygen and nutrients to cells and drive out carbon dioxide and waste products to allow cell proliferation, and expansion and biocompatibility.…”

Section: Cell-based Skin Substitutesmentioning

confidence: 99%

Bioengineered Skin Substitutes: Advances and Future Trends

Tavakoli

Klar

2021

Applied Sciences

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As the largest organ in the human body, the skin has the function of maintaining balance and protecting from external factors such as bacteria, chemicals, and temperature. If the wound does not heal in time after skin damage, it may cause infection or life-threatening complications. In particular, medical treatment of large skin defects caused by burns or trauma remains challenging. Therefore, human bioengineered skin substitutes represent an alternative approach to treat such injuries. Based on the chemical composition and scaffold material, skin substitutes can be classified into acellular or cellular grafts, as well as natural-based or synthetic skin substitutes. Further, they can be categorized as epidermal, dermal, and composite grafts, based on the skin component they contain. This review presents the common commercially available skin substitutes and their clinical use. Moreover, the choice of an appropriate hydrogel type to prepare cell-laden skin substitutes is discussed. Additionally, we present recent advances in the field of bioengineered human skin substitutes using three-dimensional (3D) bioprinting techniques. Finally, we discuss different skin substitute developments to meet different criteria for optimal wound healing.

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Tissue Engineering: Challenges and Selected Application

Cited by 4 publications

References 59 publications

Information and Scientific Impact of Advanced Therapies in the Age of Mass Media: Altmetrics-Based Analysis of Tissue Engineering

Information and Scientific Impact of Advanced Therapies in the Age of Mass Media: Altmetrics-Based Analysis of Tissue Engineering

A Review on Stimuli-Actuated 3D Micro/Nanostructures for Tissue Engineering and the Potential of Laser-Direct Writing via Two-Photon Polymerization for Structure Fabrication

Bioengineered Skin Substitutes: Advances and Future Trends

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