Chondroblastic osteosarcoma: Cytomorphologic characteristics and differential diagnosis on FNA

Abstract

BACKGROUND: Chondroblastic osteosarcoma (COS) is a uniformly fatal bone malignancy if not diagnosed and treated appropriately in a timely manner. Fine-needle aspiration (FNA) of osseous lesions is routinely performed in major medical centers. Appropriate characterization of the tumor will significantly influence patient management and outcomes. METHODS:A retrospective review of the cytopathology archives of 2 large tertiary care centers for a 15-year period (2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015) revealed 17 cases of COS (9 primary, 6 recurrent, and 2 metastatic cases) in 16 patients. Clinical outcome and histopathologic follow-up were reviewed and correlated. RESULTS: There were 9 male and 7 female patients (male-tofemale ratio of approximately 1:1), ranging in age from 12 to 70 years (mean age, 29.2 years). The classic locations for osteosarcoma were commonly involved, such as the long bones around the region of the knee in 4 cases and the proximal humerus in 1 case. However, other "nonclassic" sites also were noted to be commonly involved, including the distal tibia or fibula (4 cases), sacroiliac region (4 cases), mandible (3 cases), and skull (1 case

Chondroblastic osteosarcoma of the distal tibia: a rare case report

“…Rarely, CO has been reported to involve extra skeletal tissues, including breast, lung and intradural matter [1, 2, 6]. On the other hand, CO of the distal tibia had been reported only in two cases through English medical literature [2, 5]. So, herein we report the third case of CO involving the left distal tibia and we discuss the clinical features, the diagnosis and the management of this uncommon malignant tumour.…”

“…Chondroblastic osteosarcoma (CO) is a variant of osteosarcoma which are the most common malignant tumours of the skeleton [1, 2]. It represents about 25% of all osteosarcomas [1, 2].…”

“…It represents about 25% of all osteosarcomas [1, 2]. It most commonly occurs in the long bones of the extremities near metaphysical growth plates [1, 2].…”

“…It represents about 25% of all osteosarcomas [1, 2]. It most commonly occurs in the long bones of the extremities near metaphysical growth plates [1, 2]. Although, it has been described in other bones including mandible, clavicle, cuboid and pelvis [1–5].…”

“…Although, it has been described in other bones including mandible, clavicle, cuboid and pelvis [1–5]. Rarely, CO has been reported to involve extra skeletal tissues, including breast, lung and intradural matter [1, 2, 6]. On the other hand, CO of the distal tibia had been reported only in two cases through English medical literature [2, 5].…”