Cholinesterases of Aquatic Animals

Kozlovskaya, V. I.; Mayer, Foster L.; Menzikova, O. V.; Chuyko, G. M.

doi:10.1007/978-1-4684-7065-9_5

Cited by 37 publications

(22 citation statements)

References 49 publications

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“…The amount of enzyme present, or its activity rate, varies considerably among fish species and even tissues within a species (Kozlovskaya et al 1993). AChE is the principal neurotransmitter in animals and tends to be concentrated in brain tissue.…”

Section: Resultsmentioning

confidence: 99%

“…Thompson and Walker (1994) suggested that this elevated cholinesterase could have come from the liver. Although the majority of AChE is in nervous tissue, Kozlovskaya et al (1993) reported AChE activity in muscle and liver of fish. The parent compound of temephos has relatively low toxicity and must be metabolized to sulfone or sulfoxide forms to be lethal.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Toxicity of Abate® to Green Frog Tadpoles

Sparling

Lowe

Pinkney

1997

Bulletin of Environmental Contamination and Toxicology

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Toxicity of Abate® to Green Frog Tadpoles

Sparling

Lowe

Pinkney

1997

Bulletin of Environmental Contamination and Toxicology

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“…However invertebrate ChEs often do not follow these enzymological criteria. 42,45) In the past, in vitro studies characterized earthworm ChEs. Stenersen found at least two main ChE activities in E. fetida, which were termed E1 (an AChE activity with preference for PrSCh, inhibited by BW284c51 and insensitive to iso-OMPA) and E2 (a BChE activity inhibited by ethopropazine and by substrate excess).…”

Section: Impact Of Confounding Factors On Biomarker Responsesmentioning

confidence: 99%

Earthworm biomarkers of pesticide contamination: Current status and perspectives

Rodríguez-Castellanos

Sánchez-Hernández²

2007

Journal of Pesticide Science

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Earthworms are standard test organisms in soil toxicity testing. They have been broadly used to assess environmental impact from heavy metal pollution; however, the knowledge on toxic effects from pesticides upon these organisms is still very limited. One of the ecotoxicological approaches to assess pollutant bioavailability and sublethal effects is the use of molecular and biochemical biomarkers. This review focuses on five issues that need further investigation: 1) field validation of earthworm biomarkers of pesticide exposure (e.g., cholinesterases) as well as testing and development in earthworms of those biomarkers of pesticide exposure currently used in other organisms (e.g., carboxylesterases), 2) the impact of environmental and biological interfering factors upon biomarker responses, 3) the development of biomarker-based approaches to assess long-term pesticide exposure, and 4) the need to develop biomarkers of behavioural and reproductive disruption with direct implications at individual and population levels.

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“…The role of acetylcholinesterases (Meng and Liu 2010) in vertebrates as the main hydrolase in the neuromuscular system is well established. However, in invertebrates, there are a great variety of cholinesterases, and their function is not completely understood (Kozlovskaya et al 1993). Cholinesterases are known to preferentially hydrolyze specific substrates.…”

mentioning

confidence: 99%

“…This is important because different tissues may contain significant amounts of nonspecific esterases that may contribute to the measured activity but may show different sensitivities toward anticholinesterase agents (Kozlovskaya et al 1993;Stefano et al 2008), which could lead to biases in the interpretation of activity determination or inhibition. Therefore, the aim of this study was to characterize the esterases present in different tissues of the common cockle Cerastoderma edule using different substrates and specific inhibitors.…”

mentioning

confidence: 99%

Bivalve Esterases as Biomarker: Identification and Characterization in European Cockles (Cerastoderma edule)

Nilin

Monteiro

Domingues

et al. 2012

Bull Environ Contam Toxicol

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This study characterized esterase activity in Cerastoderma edule tissues using different substrates and specific inhibitors and identified the tissue distribution of esterases in this species. Synthetic thiocholines and thioacetate esters and specific inhibitors (eserine, BW284C51 and iso-OMPA) were used to identify and quantify cholines and carboxyl esterases. The results demonstrated the presence of a non-specific propionyl thiocholine (PrSCh)-cleaving cholinesterase (ChE) and a large amount of carboxylesterases (CaE). For further studies using C. edule esterases as biomarkers, our results suggest that the adductor muscle, with PrSCh (5 mM) as substrate should be used to analyze ChE, and for CaE analyses, phenyl thioacetate should be used in digestive gland extracts (PSA, 5 mM).

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Cholinesterases of Aquatic Animals

Cited by 37 publications

References 49 publications

Toxicity of Abate® to Green Frog Tadpoles

Toxicity of Abate® to Green Frog Tadpoles

Earthworm biomarkers of pesticide contamination: Current status and perspectives

Bivalve Esterases as Biomarker: Identification and Characterization in European Cockles (Cerastoderma edule)

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