Cholinergic system and cell proliferation

Campoy, Francisco J.; Vidal, Cecilio J.; Muñoz-Delgado, Encarnación; Montenegro, María F.; Cabezas-Herrera, Juan; Nieto, Susana

doi:10.1016/j.cbi.2016.04.014

Cited by 38 publications

(41 citation statements)

References 79 publications

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“…_____________________________________________________________________________ В настоящее время известна как нейрональная, так и не-нейрональная хо-линергические системы организма чело-века, где ацетилхолин выступает в роли нейротрансмиттера либо регулирует адге-зивные свойства клеток, деление и апоп-тоз, а также другие клеточные функции ауто и паракринно [1,2,3,4].…”

Section: Acetylcholinesterase Activity In Benign and Malignant Brain unclassified

“…Гидролиз ацетилхолина осуществля-ется ферментами холинэстеразами: аце-тилхолинэстеразой преимущественно в синапсах, нейронах и эритроцитах, и псевдохолинэстеразой в плазме крови, поджелудочной железе и печени [1,4].…”

Section: Acetylcholinesterase Activity In Benign and Malignant Brain unclassified

“…Активность холинэстераз меняется и при других патологиях: псевдохолинэсте-разы при заболеваниях печени и почек, инфаркте миокарда, мышечной дистро-фии, в то время как изменение ацетилхо-линэстеразы характерно при нейродегене-ративных заболеваниях [1,3,9]. В связи с этим большое значение может иметь сравнительный анализ активности обеих холинэстераз в крови больных с опухоля-ми различной степени злокачественности и здоровых людей.…”

Section: Acetylcholinesterase Activity In Benign and Malignant Brain unclassified

“…Получены отдельные данные о во-влечении ацетилхолинэстеразы в кон-троль пролиферации, переход клеток к апоптозу, развитие воспалительных реак-ций и формирование иммунитета [1,10,11]. Ацетилхолинэстераза выполняет роль опухолевого супрессора в культурах кле-ток опухолей даже при отсутствии фер-ментативной активности и может влиять на апоптоз раковых клеток негидролити-ческим путем; экспрессия и активность холинэстераз в тканях онкологических больных коррелирует с выживаемостью больных, и связана со степенью злокаче-ственности опухоли [6,1,7,12,13].…”

Section: Acetylcholinesterase Activity In Benign and Malignant Brain unclassified

“…Ацетилхолинэстераза выполняет роль опухолевого супрессора в культурах кле-ток опухолей даже при отсутствии фер-ментативной активности и может влиять на апоптоз раковых клеток негидролити-ческим путем; экспрессия и активность холинэстераз в тканях онкологических больных коррелирует с выживаемостью больных, и связана со степенью злокаче-ственности опухоли [6,1,7,12,13].…”

Section: Acetylcholinesterase Activity In Benign and Malignant Brain unclassified

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Acetylcholinesterase Activity in Benign and Malignant Brain Tumours: The Comparative Assay

KOROBOV¹,

ZAMYATIN²,

MAYERSHINA³

et al. 2017

NMJ

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Section: Acetylcholinesterase Activity In Benign and Malignant Brain unclassified

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Acetylcholinesterase Activity in Benign and Malignant Brain Tumours: The Comparative Assay

KOROBOV¹,

ZAMYATIN²,

MAYERSHINA³

et al. 2017

NMJ

View full text Add to dashboard Cite

Apoptosis in the neuroprotective effect of α7 nicotinic receptor in neurodegenerative models

Mugayar,

da Silva Guimarães,

de Oliveira

et al. 2023

J of Neuroscience Research

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The α7 subtype of nicotinic receptors (α7 nAChRs) is one of the most abundant nicotinic receptor subtypes in the central nervous system (CNS) and both neurons and nonneuronal cells express α7 nAChRs. When activated, α7 nAChRs become permeable to cations and promote cellular responses such as anti‐apoptotic signaling by modulating the caspases and proteins of the Bcl‐2 family. Neuroprotection is an important function of these receptors, promoting neuronal survival under pathological conditions, including situations of stress and neuronal degeneration. Studies have demonstrated the relationship between the activation of these receptors and the reduction of neuronal or glial cell injury, by controlling apoptotic processes in different models, including neurodegenerative diseases such as Alzheimer's disease. Therefore, one of the most important signaling pathways activated by α7 nAChRs is the PI3K/Akt signaling cascade, which promotes the stimulation of anti‐apoptotic molecules of the Bcl‐2 family, Bcl‐2 and Bcl‐xl, and reduces the expression of caspases and proapoptotic molecules, resulting in cell survival. In Alzheimer's models, the literature shows that α7 nAChR activation attenuates Aβ‐induced neurotoxicity through modulation of different intrinsic apoptotic pathways via PI3K/Akt and mitogen‐activated protein kinase (MAPK). In this review, we provide an up‐to‐date summary of the current evidence on the relationship between the activation of α7 nAChRs, a subtype of nicotinic acetylcholine receptor, and its role in neuroprotection by modulating apoptotic pathways.

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Autonomic nervous system and cancer

et al. 2018

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The autonomic nervous system (ANS) is the main homeostatic regulatory system of the body. However, this widely distributed neural network can be easily affected by cancer and by the adverse events induced by cancer treatments. In this review, we have classified the ANS complications of cancer into two categories. The first includes direct cancer-related complications, such as primary ANS tumors (pheochromocytoma, paraganglioma or neuroblastoma), as well as autonomic manifestations induced by non-primary ANS tumors (primary brain tumors and metastases). The second comprises indirect ANS complications, which include autonomic features related to cancer therapy (chemotherapy, radiotherapy and/or surgery) and those not related to cancer therapy, such as paraneoplastic autonomic syndromes. We also review the molecular relationship and modulation between the ANS and the cancer cells and their microenvironment.

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Cholinergic system and cell proliferation

Cited by 38 publications

References 79 publications

Acetylcholinesterase Activity in Benign and Malignant Brain Tumours: The Comparative Assay

Acetylcholinesterase Activity in Benign and Malignant Brain Tumours: The Comparative Assay

Apoptosis in the neuroprotective effect of α7 nicotinic receptor in neurodegenerative models

Autonomic nervous system and cancer

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