Cholinergic signalling mechanisms and early implant healing phases in healthy versus generalized aggressive periodontitis patients: A prospective, case–control study

Abstract

Aims Periodontal diseases negatively affect implant osseointegration. Perturbations in non‐neuronal cholinergic signalling mechanisms are associated with periodontitis; however, their role in generalized aggressive periodontitis (GAgP) is unknown. The aim of this prospective case–control study was to determine the relationship between non‐neuronal cholinergic signalling mechanisms, secreted Ly‐6/uPAR‐related protein‐1 (SLURP‐1), interleukin‐17 (IL‐17) family cytokines and healing of dental implants in health and GAgP. Material and Methods Thirteen GAgP patients and seven periodontally healthy individuals (PH) were recruited. Peri‐implant crevicular fluid (PICF) was obtained at baseline and 1 month post‐placement. Acetylcholine (ACh) levels and cholinesterase activity were determined biochemically. SLURP‐1, IL‐17A and IL‐17E levels were determined by ELISA. Marginal bone loss (MBL) at 1 and 6 months post‐placement was determined radiographically. Results The concentration of ACh, cholinesterase activity and IL‐17A levels was elevated in PICF of patients with GAgP compared to PH individuals at baseline and 1 month post‐placement. The concentration of ACh and cholinesterase activity levels in PICF correlated with levels of IL‐17A and MBL around implants 1 month post‐placement in patients with GAgP. Conclusions Non‐neuronal cholinergic mechanisms may play a role in the aetiopathogenesis of GAgP and may directly or indirectly, through modulation of IL‐17A, influence early implant osseointegration and potential long‐term implant survival.

<p>Treatment of an Endo-Perio Lesion with Ozone Gas in a Patient with Aggressive Periodontitis: A Clinical Case Report and Literature Review</p>

“…8 Periodontal diseases such as aggressive periodontitis negatively affect implant osseointegration. 9 Thus, clinicians should save such teeth rather than extract them and replace them with implants. 10 Comparing the survival rate between endodontically treated teeth with poor prognosis and implants placed in previously diseased sites showed that the survival rate of endodontically treated teeth was comparatively higher than implants.…”