Cholinergic link in the histamine-mediated increase in homovanillic acid in the rat striatum

Nowak, Jerzy Z.; Maśliński, Cz.

doi:10.1007/bf01964877

Cited by 14 publications

(2 citation statements)

References 27 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The importance of cholinergic receptors in regulation of the CRF and ACTH secretion in both the isolated rat hypothalamo-pituitary unit in vitro and different species in vivo has been well documented [3, 13,23,25,26]. The lack of effect of atropine on the histamine-or PEA-and dimapritinduced corticosterone secretion in the present experiment, while finding that this drug abolishes the carbachol-induced hormone secretion, suggests that cholinergic muscarinic pathways are not involved in the corticosterone response to centrally administered histamine or Hi-and H2-agonists in stressed rats.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Adrenergic and Cholinergic Antagonists on Central Histaminergic Stimulation of Pituitary-Adrenocortical Response under Stress in Rats

Bugajski¹,

Gadek²

1984

Neuroendocrinology

View full text Add to dashboard Cite

A possible interaction of central histaminergic receptors with adrenergic and cholinergic muscarinic neurons in increasing the pituitary-adrenocortical response under stress, assessed indirectly from the corticosterone concentration in blood serum, was investigated in conscious rats. All the drugs were administered intracerebroventriculary, the antagonists 15 to 30 min prior to the agonists. The histamine-induced increase in serum corticosterone levels of stressed rats was considerably antagonized by prazosin, phenoxybenzamine, phentolamine and yohimbine, α₁ and α₂-adrenergic antagonists. These antagonists abolished or significantly attenuated the corticosterone response to 2-pyridylethylamine (PEA), an H₁-receptor agonist, and to dimaprit and 4-methylhistamine(4-MeHA), H₂-receptor agonists. Propranolol, a β-adrenergic blocker, did not substantially change the corticosterone response induced by histamine or histamine H₁- and H₂-receptor agonists. Similarly, atropine was ineffective in blocking the increase in serum corticosterone responses induced by either histamine or PEA and dimaprit in stressed rats. These results suggest that both α₁- and α₂-adrenergic receptors, but not β-adrenergic and cholinergic muscarinic receptors interact with central H₁ and H₂ histaminergic stimulation of the increased pituitary-adrenocortical response in stressed rats.

show abstract

Section: Discussionmentioning

confidence: 99%

The Effect of Adrenergic and Cholinergic Antagonists on Central Histaminergic Stimulation of Pituitary-Adrenocortical Response under Stress in Rats

Bugajski¹,

Gadek²

1984

Neuroendocrinology

View full text Add to dashboard Cite

show abstract

“…When it is administered to rats, it suppresses locomotion, producing hypokinesia or akinesia (Nowak et al, 1977).…”

Section: Molecular and Chemical I'leuropathologymentioning

confidence: 99%

Decrease in blood histamine in drug-treated Parkinsonian patients

Coelho¹,

Silva²,

Azevedo³

et al. 1991

Molecular and Chemical Neuropathology

View full text Add to dashboard Cite

Blood histamine and serum histaminase activity were determined in a group of patients with Parkinson disease (PD) and in a group of healthy controls. Untreated PD patients present significantly higher blood histamine than normal controls. Therapy with L-dopa + cardidopa results in a significant decrease in blood histamine. This decrease becomes more accentuated when anticholinergics are added to this therapy. No significant changes were detected in plasma histaminase. The authors suggest, as a hypothesis, that the CNS contributes to blood histamine concentration and that its rise is the result of increased neuronal destruction.

show abstract

Dystonic and Dyskinetic Reactions Induced by H1 Antihistaminic Medication

Smith¹,

Domino²

1980

Tardive Dyskinesia

View full text Add to dashboard Cite

Cholinergic link in the histamine-mediated increase in homovanillic acid in the rat striatum

Cited by 14 publications

References 27 publications

The Effect of Adrenergic and Cholinergic Antagonists on Central Histaminergic Stimulation of Pituitary-Adrenocortical Response under Stress in Rats

The Effect of Adrenergic and Cholinergic Antagonists on Central Histaminergic Stimulation of Pituitary-Adrenocortical Response under Stress in Rats

Decrease in blood histamine in drug-treated Parkinsonian patients

Dystonic and Dyskinetic Reactions Induced by H1 Antihistaminic Medication

Contact Info

Product

Resources

About