Abstract:Phosphatidylethanolamine (PE) is essential for mitochondrial respiration in yeast,
Saccharomyces cerevisiae
, whereas the most abundant mitochondrial phospholipid, phosphatidylcholine (PC), is largely dispensable. Surprisingly, choline (Cho), which is a biosynthetic precursor of PC, has been shown to rescue the respiratory growth of mitochondrial PE-deficient yeast; however, the mechanism underlying this rescue has remained unknown. Using a combination of yeast genetics, lipid biochemist… Show more
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