Choline chloride-based natural deep eutectic solvents for the extraction and stability of phenolic compounds, ascorbic acid, and antioxidant capacity from Citrus sinensis peel

Gómez-Urios, Clara; Viñas-Ospino, Adriana; Puchades-Colera, Pablo; Blesa, Jesús; López-Malo, Daniel; Frígola, Ana; Esteve, María J.

doi:10.1016/j.lwt.2023.114595

Cited by 19 publications

(3 citation statements)

References 50 publications

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“…Notably, there was no significant difference ( p >0.05) between the pH of DES synthesized by microwave and conventional methods. However, the pH of ChCl:MA DES measured in the current study was higher than that measured by Gómez‐Urios et al [21] . This difference could be due to several factors such as the measuring temperature, water content (or concentration of DES) and molar ratio.…”

Section: Resultscontrasting

confidence: 90%

“…The choline chloride:malic acid (ChCl:MA) DES system has gained particular attention as extraction media for a wide range of bioactive compounds such as flavonoids, polyphenols and ascorbic acid from fruits and plants [19–24] . Recently, this DES has also been explored as a co‐solvent to improve drug solubility and delivery [25–26] .…”

Section: Introductionmentioning

confidence: 99%

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Microwave‐Assisted Preparation of an Acidic Deep Eutectic Solvent: Green Analysis, Characterization and Application

Yap,

Wang,

Gan

2024

ChemistrySelect

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Microwave irradiation was postulated to reduce time and energy for deep eutectic solvent (DES) production which is in line with the principle of green chemistry. In this study, the choline chloride (ChCl)‐malic acid (MA) DES was prepared using microwave‐assisted (DES‐Mic) and conventional (DES‐Con) approaches. Microwave was a relatively greener approach as it was rapid (5 min) and consumed 92.8 % energy less than DES‐Con. Moreover, DES‐Mic and DES‐Con exhibited similar physicochemical profiles (pH, solubility, density) and rheological properties. Structural profiling through FTIR analysis suggested hydrogen bond formation between the functional groups of ChCl and MA. The FTIR spectra also did not show structural differences in the DES synthesized using different methods. DES‐Mic and DES‐Con exhibited superior 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) (80.8±0.1 and 83.2±0.3 %, respectively) free radical scavenging activities than ChCl (15.6±0.8 %), MA (20.0±1.4 %) and ChCl:MA aqueous mixture without subjected to DES synthesis conditions (ChCl:MAaq; 23.3±0.8 %). Both DES were also proven as more efficient solvents for the extraction of polysaccharides from ramie leaf, as they recorded higher yields (21.4±1.9 and 22.2±1.0 %, respectively) than equimolar of MA (17.7±2.6 %) and ChCl (6.4±0.2 %). Overall, microwave was proven as a more sustainable approach for DES preparation compared to conventional method, which could be further improvised for industrial applications.

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Section: Resultscontrasting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Microwave‐Assisted Preparation of an Acidic Deep Eutectic Solvent: Green Analysis, Characterization and Application

Yap,

Wang,

Gan

2024

ChemistrySelect

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“…Low saturated vapor pressure, low cost, biodegradability, compatibility with chromatographic detection methods, and high extraction ability have led to the widespread use of these solvents in the practice of analysing plant materials. 38 Choline chloride (CC) is widely used in DESs for plant metabolites extraction [39][40][41][42] with great success. It allows obtaining extracts with higher active substances content, 43 isolate them from industrial plant waste, 44 improve the quality of essential oils, 45 and enhance in vivo bioavailability.…”

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confidence: 99%

Selective extraction of plant bioactive compounds with deep eutectic solvents: Iris sibirica L. as example

Karpitskiy,

Bessonova,

Shishov

et al. 2023

Phytochemical Analysis

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IntroductionDeep eutectic solvents (DESs) are promising extractants with tuneable properties. However, there is a lack of reports about the influence of the nature of the original DES on obtaining the metabolomic profile of a plant.ObjectiveThe aim of this study is to investigate the possibility of obtaining Iris sibirica L. chromatographical profiles with DESs based on various hydrogen bond donors and acceptors as extraction solvents.MethodologyDESs were prepared by mixing choline chloride or tetrabutylammonium bromide with various hydrogen bond donors and investigated for the extraction of bioactive substances from biotechnological raw materials of I. sibirica L. The obtained extracts were analysed by HPLC with diode array detector (DAD) and Q‐MS.ResultsChromatographic profiles for I. sibirica L. extracts by eight choline chloride DESs and six tetrabutylammonium DESs have been obtained. It has been found that selective recovery of bioactive substances can be achieved by varying the composition of DESs. Eleven phenolic compounds were identified in I. sibirica L. using HPLC‐MS. Phase separation was observed with acetonitrile for four DESs. New flavonoid derivatives have been found in DES extracts compared with methanol extracts.ConclusionThe results showed the possibility of DES usage for extraction without water addition. Selectivity of DESs varies depending on the chemical composition of hydrogen bond donors and acceptors. Choline chloride is a more suitable hydrogen bond acceptor for the flavonoid extraction. Choline chloride–lactic acid (1:1) DES has demonstrated a metabolic profile that was the closest to the methanol one and enhanced the extraction up to 2.6‐fold.

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Improving carotenoid extraction, stability, and antioxidant activity from Citrus sinensis peels using green solvents

Viñas-Ospino

López-Malo

Esteve

et al. 2023

Eur Food Res Technol

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Carotenoids have a wide range of applications in the food, pharmaceutical, and cosmetic industries as natural coloring agents and antioxidants. Consequently, industries are more concerned about extracting them from natural resources and by-products. The present research aimed to evaluate the extraction efficiency of carotenoids from orange peels using hydrophobic deep eutectic solvents (HDESs) as alternatives for organic solvents. The antioxidant capacity and color stability of HDESs extracts were monitored for 20 days and to intensify the extraction process, ultrasound-assisted extraction (UAE) was optimized using a response surface methodology (RSM). Menthol:Eucalyptol (Me:Eu) extract showed the highest carotenoid extraction yield [359.3 ± 3.5 mg/100 g of fresh weight (fw)], and also presented high stability during the storage period. HDESs extracts showed higher antioxidant capacity compared to hexane extracts, while Me:Eu extracts showed the lowest color variation (5.9 ± 0.2). Optimal parameters using Me:Eu were extraction time of 20 min, ultrasonic power of 120 W (60%), and solid–liquid ratio of 1:20 (g/mL) reaching a carotenoid content of 573.4 mg/100 gfw. While, C12:C8 optimal parameters were 10 min, 80 W (40%), and a solid–liquid ratio of 1:10 (g/mL), providing a carotenoid content of 183.7 mg/100 gfw. To establish if the solvents used are greener alternatives, the EcoScale was used and showed that UAE is a sustainable method to recover carotenoids using HDESs. Overall, the results showed that HDESs can improve carotenoid stability, and when combined with the intrinsic safety and edibility of their components, it makes these extracts appealing for food industry.

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Choline chloride-based natural deep eutectic solvents for the extraction and stability of phenolic compounds, ascorbic acid, and antioxidant capacity from Citrus sinensis peel

Cited by 19 publications

References 50 publications

Microwave‐Assisted Preparation of an Acidic Deep Eutectic Solvent: Green Analysis, Characterization and Application

Microwave‐Assisted Preparation of an Acidic Deep Eutectic Solvent: Green Analysis, Characterization and Application

Selective extraction of plant bioactive compounds with deep eutectic solvents: Iris sibirica L. as example

Improving carotenoid extraction, stability, and antioxidant activity from Citrus sinensis peels using green solvents

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