Choline chloride and tartaric acid, a Natural Deep Eutectic Solvent for the efficient extraction of phenolic and carotenoid compounds

Koutsoukos, Spyridon; Tsiaka, Thalia; Tzani, Andromachi; Zoumpoulakis, Panagiotis; Detsi, Anastasia

doi:10.1016/j.jclepro.2019.118384

Cited by 108 publications

(42 citation statements)

References 35 publications

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“…Total condensed tannins content (TCTC) of the extracts was determined according to Koutsoukos et al [ 18 ], with slight modifications. Briefly, 150 μL samples were mixed with 1000 μL vanillin methanol solution and 500 μL hydrochloric acid.…”

Section: Methodsmentioning

confidence: 99%

Green Extraction of Phenolic Compounds from Lotus Seedpod (Receptaculum Nelumbinis) Assisted by Ultrasound Coupled with Glycerol

Bao

Gao

et al. 2021

Foods

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Lotus Receptaculum Nelumbinis has been sparking wide research interests due to its rich phenolic compounds. In the present work, ultrasonic-assisted extraction coupled with glycerol was employed to extract phenolic compounds from Receptaculum Nelumbinis and the process was optimized using a response surface methodology with Box-Behnken design (BBD). The optimal conditions for the total phenolic content (TPC) extract were obtained: glycerol concentration of 40%, an extraction temperature of 66 °C, ultrasonic time of 44 min, and the solvent-to-solid ratio of 55 mL/g. Under these optimum extraction conditions, the extraction yield of TPC was 92.84 ± 2.13 mg gallic acid equivalents (GAE) /g. Besides, the antioxidant activities demonstrated the ability of free radical scavenging by four different methods that included 2,2-Diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and reducing activity (RA) were 459.73 ± 7.07, 529.97 ± 7.30, 907.61 ± 20.28, and 983.66 ± 11.80 μmol TE/g, respectively. Six phenolic compounds were identified by ultra-high pressure liquid chromatography combined with triple-time-of-flight mass spectrophotometry (UPLC-Triple-TOF/MS) from the extracts. Meanwhile, Fourier transform infrared (FTIR) was conducted to identify the characteristic functional groups of the extracts and thus reflected the presence of polyphenols and flavonoids. Scanning electron microscopy (SEM) illustrated the microstructure difference of four treatments, which might explain the relationships between antioxidant activities and the structures of phenolic compounds.

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Section: Methodsmentioning

confidence: 99%

Green Extraction of Phenolic Compounds from Lotus Seedpod (Receptaculum Nelumbinis) Assisted by Ultrasound Coupled with Glycerol

Bao

Gao

et al. 2021

Foods

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“…In this way, the viscosity is lowered and the extraction is facilitated [35,36]. In the recent work of Koutsoukos et al, water was used as a co-solvent for the extraction of phenolic compounds from brown propolis using ChCl/tartaric acid NaDES, with methanol used as the co-solvent for the extraction of carotenoids from apricot pulp and shrimp head by-products using the same NaDES [37].…”

Section: Viscositymentioning

confidence: 99%

Deep Eutectic Solvents as Extraction Media for Valuable Flavonoids from Natural Sources

2019

Self Cite

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The present review article attempts to summarize the use of deep eutectic solvents in the extraction of flavonoids, one of the most important classes of plant secondary metabolites. All of the applications reviewed have reported success in isolation and extraction of the target compounds; competitive, if not superior, extraction rates compared with conventional solvents; and satisfactory behavior of the extract in the latter applications (such as direct analysis, synthesis, or catalysis), wherever attempted.

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“…Tartaric is a polyhydroxyl binary carboxylic acid, and ethylenediamine contains nitrogen. Both of them are environmentally friendly [36,37] raw materials. Brown and well-distributed C/N-dots solution was obtained with a simple hydrothermal treatment of raw materials at 180 °C for 5 h. TEM characterization results clearly revealed that the C/N-dots were spherical dots and well dispersed from each other, with a diameter of about 3.2 nm.…”

Section: Resultsmentioning

confidence: 99%

Sensitively and Selectively Detect Biothiols by Using Fluorescence Method and Resonance Light Scattering Technique Simultaneously

et al. 2019

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In this paper, we designed a new quantitative and qualitive detection method for biothiols by using fluorescence method and resonance light scattering (RLS) technique. Nitrogen doped carbon quantum dots (C/N-dots) were obtained from tartaric acid and ethylenediamine by hydrothermal method, and then their morphology and optical properties were characterized by different techniques. A detection system consisting of C/N-dots and Ag+ complex was established. In this system, C/N-dots possessed the photoluminescent property and the Ag+ complex owned the RLS property, so, by combining the two luminescent properties to achieve complementary advantages, we could detect biothiols and solve the problem of distinguishing between Cys and GSH. Additionally, we optimized detecting conditions and investigated the detection mechanism of fluorescence quenching and RLS detecting. Results showed that the analytical response of fluorescence was linear in the range 0–140 μM and the detection limit (LOD) was calculated to be 6.6 μM for Cys, and the addition of GSH had no effect on fluorescence. RLS response ranges were 0–167 μM for Cys and 0–200 μM for GSH, with LOD down to 64 nM and 74 nM, respectively. Furthermore, the probe was successfully used for detecting Cys in fetal bovine serum (FBS) samples by fluorescence method, and also, by RLS technique, the content of GSH in FBS samples was detected.

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Choline chloride and tartaric acid, a Natural Deep Eutectic Solvent for the efficient extraction of phenolic and carotenoid compounds

Cited by 108 publications

References 35 publications

Green Extraction of Phenolic Compounds from Lotus Seedpod (Receptaculum Nelumbinis) Assisted by Ultrasound Coupled with Glycerol

Green Extraction of Phenolic Compounds from Lotus Seedpod (Receptaculum Nelumbinis) Assisted by Ultrasound Coupled with Glycerol

Deep Eutectic Solvents as Extraction Media for Valuable Flavonoids from Natural Sources

Sensitively and Selectively Detect Biothiols by Using Fluorescence Method and Resonance Light Scattering Technique Simultaneously

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