Choline and phosphatidylcholine

Klatt, Kevin C

doi:10.1016/b978-0-12-821848-8.00020-2

Cited by 3 publications

(1 citation statement)

References 124 publications

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“…NAFLD is an independent risk factor for CVD and impairs renal function via lipoprotein dysmetabolism, increases oxidative stress and decreases antioxidant enzymes, elevates inflammatory cells infiltration [5,45,46] Besides a vital role in cell membrane integrity, acting as a methyl donor and lipotropic action of choline, it has antioxidant properties. choline supplementation and betaine, a derivative Zag Vet J, Volume 51, Number 4, p326-343 December 2023 of choline, reduced oxidative stress and the inflammatory response in mice [47][48][49] indicating that a high intake of choline protective against inflammation and related diseases such as NAFLD, CVD and improved renal function [50]. This demonstrates that choline plays a significant role in maintaining the proper histological integrity and functioning of renal and cardiac tissues.…”

Section: Discussionmentioning

confidence: 95%

Effect of Choline and Vitamin E Co-Treatment on Hedgehog Pathway and Histopathological Changes in Heart and Kidney Associated with Obese Rats with Non-Alcoholic Fatty Liver Disease

Abdelrahman,

Fawzy,

Mansour

2023

Zagazig Veterinary Journal

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An increase in the prevalence of non-alcoholic fatty liver disease (NAFLD) is related to an elevation in obesity worldwide. NAFLD is a prevalent liver disorder characterized by excessive lipid accumulation in hepatocytes, primarily induced by a high-fat diet (HFD). NAFLD not only affects the liver but also has significant implications for other organs, including the kidney and heart. The Hedgehog pathway, a critical signaling cascade involved in cellular processes and development, has emerged as a potential player in the pathogenesis of NAFLD and its extrahepatic effects. The purpose of the present study was to study impacts of choline and vitamin E co-treatment on the molecular and histopathological changes in heart and kidney in an obese rat model with NAFLD induced by a high-fat diet. Fifty albino rats were grouped into five equal groups randomly. The first one was kept as a control group the remaining four groups were treated as follows; G2: NAFLD, G3: NAFLD and received low dose of choline (25 mg/kg BW orally) and vitamin E (50 mg/kg BW orally), G4: NAFLD and received medium dose of choline (50 mg/kg BW orally) and vitamin E (100 mg/kg BW orally) and G5: NAFLD and received high dose of choline (100 mg/kg BW orally) and vitamin E (200 mg/kg BW orally). The results revealed that treating rats with varying dosages of choline and vitamin E significantly reduced Hhip, Ptch1, Smo and Gli1 hepatic mRNA expression in choline and vitamin E co-treated groups in comparison to NAFLD group and histologically displayed ameliorative consequences on kidney and heart tissues. In conclusion, choline and vitamin E co-treatment relieves the molecular and histological consequences of NAFLD in rats, with dose dependent manner.

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Section: Discussionmentioning

confidence: 95%

Effect of Choline and Vitamin E Co-Treatment on Hedgehog Pathway and Histopathological Changes in Heart and Kidney Associated with Obese Rats with Non-Alcoholic Fatty Liver Disease

Abdelrahman,

Fawzy,

Mansour

2023

Zagazig Veterinary Journal

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Diagnostic Potential of Free Blood Choline as a Biomarker of the Physiological Status of the Organism

Savelieva,

Leninskii,

Goncharov

2023

J Evol Biochem Phys

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Diagnostic Potential of Free Blood Choline as a Biomarker of the Physiological Status of the Organism

Savelieva,

Leninskii,

Goncharov

2023

Rossijskij fiziologičeskij žurnal im. I.M. Sečenova

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Choline is an essential nutrient. Mitochondrial dysfunctions, oxidative stress and associated risks of developing non-alcoholic fatty liver disease, cardiovascular disease, muscular dystrophy, and fetal neural tube pathology are associated with insufficient choline intake. At the same time, excessive consumption of choline is associated with the accumulation in the blood of a uremic toxin – trimethylamine oxide, the bioprecursor of which is not phosphatidylcholine, but free blood choline. The content of choline and its metabolites in blood plasma is associated with different types of vascular pathologies, and allows predicting the severity of cardiovascular and other associated diseases. Contradictory information about the norm and deviations from the norm of the content of free choline in the blood plasma is due to insufficient attention to the stabilization of the content of free choline in the blood plasma at the stages preceding the instrumental analysis. When using EDTA as an anticoagulant and following a cold regimen (not higher than 4°C) immediately after blood sampling and 23 up to instrumental analysis, it is possible to avoid an increase in the concentration of choline in ex vivo plasma.

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Choline and phosphatidylcholine

Cited by 3 publications

References 124 publications

Effect of Choline and Vitamin E Co-Treatment on Hedgehog Pathway and Histopathological Changes in Heart and Kidney Associated with Obese Rats with Non-Alcoholic Fatty Liver Disease

Effect of Choline and Vitamin E Co-Treatment on Hedgehog Pathway and Histopathological Changes in Heart and Kidney Associated with Obese Rats with Non-Alcoholic Fatty Liver Disease

Diagnostic Potential of Free Blood Choline as a Biomarker of the Physiological Status of the Organism

Diagnostic Potential of Free Blood Choline as a Biomarker of the Physiological Status of the Organism

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