Abstract:Choline and geranic acid (CAGE) ionic liquids have recently been shown to have applications in the delivery of macromolecules and poorly soluble drugs across epithelial barriers and in bacterial growth inhibition. Ionic liquids are known to denature proteins by the disruption of forces that guide natural protein folding, and the inflammatory enzyme elastase was recently shown to be inhibited by a variety of ionic liquids other than CAGE. Inhibition of collagenolytic enzymes, including elastase, has been shown … Show more
“…165 Choline geranic acid ILs (CAGE) could inhibit human neutrophil elastase at low concentrations by disrupting the hydrophobic effect. 169 Besides, the addition of ILs can change the pH of the environment and denature proteins. [EMIM][BF 4 ] could cause conformational changes of BSA, resulting in the formation of amyloid fibers.…”
Section: Interactions Between Ils and Cell Organellesmentioning
This review highlights the recent advances and emerging opportunities of ionic liquids in biomedicine based on their intrinsic advantages and potentials.
“…165 Choline geranic acid ILs (CAGE) could inhibit human neutrophil elastase at low concentrations by disrupting the hydrophobic effect. 169 Besides, the addition of ILs can change the pH of the environment and denature proteins. [EMIM][BF 4 ] could cause conformational changes of BSA, resulting in the formation of amyloid fibers.…”
Section: Interactions Between Ils and Cell Organellesmentioning
This review highlights the recent advances and emerging opportunities of ionic liquids in biomedicine based on their intrinsic advantages and potentials.
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