Cholesteryl sulfate and sterol sulfatase in the human reproductive tract

Lalumière, Gaston; Bleau, G.; Chapdelaine, A.; Roberts, Kenneth D.

doi:10.1016/0039-128x(76)90101-x

Cited by 73 publications

(28 citation statements)

References 24 publications

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“…npg Bloch biochemical pathway. Various proportions of this unusual sterol have also been reported in human semen [19] and in the semen of other mammalian species such as the rhesus monkey [20], hamster [21] and boar [22]. In particular, we found that this molecule is more abundant than the cholesterol present in rabbit spermatozoa, seminal plasma and PSGs.…”

Section: Discussionsupporting

confidence: 67%

Desmosterol, the main sterol in rabbit semen: distribution among semen subfractions and its role in the in vitro spermatozoa acrosome reaction and motility

Mourvaki¹,

Cardinali²,

Roberti³

et al. 2010

Asian J Androl

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Section: Discussionsupporting

confidence: 67%

Desmosterol, the main sterol in rabbit semen: distribution among semen subfractions and its role in the in vitro spermatozoa acrosome reaction and motility

Mourvaki¹,

Cardinali²,

Roberti³

et al. 2010

Asian J Androl

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“…The cholesterol : phospholipid ratio and concentration of phosphatidylserine, phosphatidylethanolamine, cardiolipin, and ethanolamine plasmalogen decrease in whole ram sperm [20,27]. However, increases occur in the amount of the sulphoconjugated sterols in whole hamster and human sperm [28][29][30] and in unsaturated fatty acids in whole ram sperm [27]. Studies using plasma membrane isolated from boar spermatozoa confirm earlier results with whole sperm that the amount of lipid decreases during epididymal maturation [18].…”

Section: Introductionsupporting

confidence: 72%

Role of Membrane Lipid Fatty Acids in Sperm Cryopreservation

Mandal

Badyakar

Chakrabarty

2014

Advances in Andrology

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Lipid is an important constituent of cell membrane. Membrane lipid composition of spermatozoa has been correlated to different function. Many researchers have related membrane lipid with survival success after cryopreservation or cold shock. Sperm maturation and acrosome reactions are natural phenomenon, but cryopreservation or cold shock is not. Therefore, sperm cells are not programmed for such change and undergo stress. So the change in membrane lipid composition due to cold shock or cryopreservation may be looked upon as response of spermatozoa to a certain stressed condition. A significant body of research worked on the relationship between membrane lipid and fatty acid composition and ability of cell to tolerate adverse change in temperature. However, as the approach of different research groups was different, it is very difficult to compare the changes. Studies have been done with different species, ejaculated/seminal or epididymal sperm. Lipid analyses have been done with whole cell membrane isolated by different methods. Fatty acids estimated were from whole cell, plasma membrane, head membrane, or phospholipids. The cryopreservation condition, media composition, and diluents/cryoprotectants were also different. At this onset a comprehensive review is needed to cover changes of sperm membrane lipid composition of different species under different cryopreservation conditions.

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“…Other sterol compounds found in the semen are sterol sulfates. The sterol sulfate fraction of human ejaculated spermatozoa contains 85% cholesterol sulfate ( 94 ), which represents about 6% of total cholesterol in spermatozoa ( 89 ). By contrast, the sterol sulfate fraction of hamster spermatozoa is composed almost exclusively of desmosterol sulfate ( 95 ).…”

Section: Functional Role Of Sterols In Sperm Developmentmentioning

confidence: 99%