Cholesterotic Fibrous Histiocytoma

Yu, Mi; Kim, Mi Sun; Han, Tae Young; Lee, June Hyunkyung; Son, Sook‐Ja

doi:10.1097/dad.0b013e3182817be2

Cited by 6 publications

(13 citation statements)

References 10 publications

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“…Another differential diagnosis in this case includes lipidized fibrous histiocytoma. Although lipidized fibrous histiocytomas sometimes have cholesterol clefts, it is only a minor and infrequent finding [ 5 ] in their granulomatous lesions, whereas it is a predominant characteristic in our case; cholesterotic fibrous histiocytoma is defined as cholesterol deposition within the center of the lesion [ 2 ]. In addition, there was no hyalinized wiry collagen in the stroma of the specimen of this patient, which is known to be pathognomonic of lipidized fibrous histiocytoma [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

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Cholesterotic Fibrous Histiocytoma in a Patient with Metabolic Syndrome

Deguchi

Aiba

2017

Case Rep Dermatol

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Among the many variants of dermatofibroma, dermatofibroma with cholesterol cleft (cholesterotic fibrous histiocytoma) is extremely rare. Here, we describe the case of a 50-year-old male patient with a cholesterotic fibrous histiocytoma on his left lower leg. He presented with a hyperkeratotic nodule 6 mm in diameter with a brown surface on the extensor surface of his left lower leg. The lesion had developed over the course of a few years without any tendency to heal. A skin biopsy performed on the tumor showed histopathological findings compatible with those of dermatofibroma. Interestingly, the lesion included many cholesterol clefts, as well as foamy histiocytes and multinucleated giant cells around them. He had had metabolic syndrome for years. To the best of our knowledge, this is the first report of a cholesterotic fibrous histiocytoma in a patient with metabolic syndrome. We conclude that the altered microenvironment caused by metabolic syndrome, as well as hyperlipoproteinemia itself, may play a role in the pathogenesis of this rare case.

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Section: Discussionmentioning

confidence: 99%

“…Furthermore, we could find only 3 definitive reports of cholesterotic fibrous histiocytoma associated with hyperlipoproteinemia. The first report was published by Hunt et al [ 1 ] in 1990, followed by the reports by Yu et al [ 2 ] and Takahashi et al [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Cholesterotic Fibrous Histiocytoma in a Patient with Metabolic Syndrome

Deguchi

Aiba

2017

Case Rep Dermatol

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“…Periocular lesions including extraocular muscles and the orbit are rarely involved. 2,3 Here, we report an unusual case of Kimura disease that caused severe visual dysfunction due to prominent periorbital involvement.…”

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confidence: 92%

“…2 Although mechanisms underlining cholesterol crystal deposition are uncertain, cases with hyperlipidemia have been reported, 2,3 and our patient also had a history of hyperlipidemia. Yu et al 3 speculated that vascular leakage of lipoproteins, possibly triggered by local trauma, and subsequent phagocytosis by dermal macrophages may lead to accumulation of lipid materials in their cytoplasm, eventually forming cholesterol crystals. Indeed, upon co-culture with oxidized lowdensity lipoprotein (LDL), histiocytes are reported to transform into foam cells with cholesterol crystals in their lysosomes.…”

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confidence: 99%

Electron microscopic observation of cholesterotic fibrous histiocytoma of the finger

Takahashi

Hayama

Inadomi

et al. 2015

The Journal of Dermatology

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“…Therefore, the authors suggested that a relationship between cholesterol deposits and HIV infection exists. Furthermore, a very recent paper reported the case with type 2 hyperlipidemia …”

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confidence: 99%