Cholesterol-rich diets have different effects on lipid peroxidation, cholesterol oxides, and antioxidant enzymes in rats and rabbits

Mahfouz, Mahmoud; Kummerow, Fred A.

doi:10.1016/s0955-2863(00)00083-8

Cited by 122 publications

(100 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to a direct toxic effect, superoxide anion can react with nitric oxide to give peroxynitrite radical or hydrogen peroxide 31) . It has been proved that cholesterol feeding would result in increased lipid peroxidation in rabbits 30) , and a similar observation was made in this study also. Polyunsaturated fats have been shown to increase the rate of lipid peroxidation compared to saturated fats in Wistar rats 29) .…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Effect of High Fat Diet Without Cholesterol Supplementation on Oxidative Stress and Lipid Peroxidation in New Zealand White Rabbits

Sabitha

Vasudevan

Kamath

2010

JAT

View full text Add to dashboard Cite

Aim: Dietary fats may affect coronary artery disease risk by influencing factors other than serum cholesterol. The effect of diets containing coconut oil and sunflower oil without cholesterol supplementation on oxidative stress and lipid peroxidation was studied in male New Zealand White rabbits. Methods: Animals assigned to four groups (control, cholesterol-fed, coconut oil-fed and sunflower oil-fed), given an isocaloric diet and studied for 6 months. The lipid profile, reduced glutathione, glutathione peroxidase, superoxide dismutase, vitamin C and lipid peroxidation were evaluated at the beginning of the study, at the third month and at the end of the study period. Results: Serum lipid values did not show significant variation between animals fed coconut oil and sunflower oil, but total cholesterol, triglycerides and LDL-cholesterol were significantly higher and HDL-cholesterol was reduced in cholesterol-fed animals. Lipid peroxidation was higher in cholesterol-fed and sunflower oil-fed rabbits compared to controls and coconut oil-fed rabbits. Though other parameters such as reduced glutathione, glutathione peroxidase, superoxide dismutase and ascorbate did not vary between the two oil-fed rabbit groups, cholesterol-fed rabbits showed severe oxidative stress. Conclusion: We conclude that in the absence of cholesterol supplementation, coconut oil intake up to 30% of daily energy supply did not cause hypercholesterolemia or oxidative stress in rabbits.J Atheroscler Thromb, 2010; 17:213-218.

show abstract

Section: Discussionsupporting

confidence: 89%

“…It was shown previously in rabbits that cholesterol feeding reduced GSH-Px and catalase activity in the liver 30) . Investigators reported previously that increased oxidative stress observed after a high cholesterol diet may be the result of increased superoxide production.…”

Section: Discussionmentioning

confidence: 79%

Effect of High Fat Diet Without Cholesterol Supplementation on Oxidative Stress and Lipid Peroxidation in New Zealand White Rabbits

Sabitha

Vasudevan

Kamath

2010

JAT

View full text Add to dashboard Cite

show abstract

“…In the present experiment, the MDA level was significantly decreased in mouse fed with TFs. These findings are in accordance with those of other investigators [22].…”

Section: Discussionsupporting

confidence: 94%

The antioxidant activity and hypolipidemic activity of the total flavonoids from the fruit of Rosa laevigata Michx

Lu¹,

Xu²,

Yin³

et al. 2010

View full text Add to dashboard Cite

In the present work, the antioxidant activity in vitro and hypolipidemic activity of the total flavonoids (TFs) from the Rosa laevigata Michx fruit was evaluated, and the antioxidant effect in vivo was also discussed. The TFs exhibited a high scavenging effect on 2, 2-diphenyl-1-picrylhydrazyl (·DPPH) with IC 50 values 0.01 mg/mL, and a stong reduce power in the test. Hyperlipemic mice were intragastric administrated with TFs (25, 50 mg/kg/day) for 4 weeks, and fenofibrate was used as the positive reference substance. After the experiment, the levels of TC (total cholesterol), TG (triglyceride), LDL-C (low density lipoprotein-cholesterol) of the mice administrated with high-dose of TFs were markedly declined by 45.02%, 33.86% and 73.68%, respectively, while HDL-C (high density lipoprotein-cholesterol) was significantly increased compared with model group. To investigate the hepatoprotective effect, histopathological assay, ALT (alanine aminotransferase), AST (aspartate aminotransefrase) and ALP (alkaline phosphatase) were also studied, and the results showed that TFs exhibited a favorable effect on liver protection, of which the levels of ALT, AST and ALP were elevated by 55.85%, 29.15% and 25.68%, respectively. Furthermore, the TFs could significantly decrease the MDA (malondialdehyde) level and improve the levels of CAT (Catalas), SOD (superoxide dismutase), GSH (reduced glutathione), and GPX (glutathione peroxidase) compared with hyperlipemia mice. Our results suggested that TFs has a high antioxidant activity and hypolipidemic activity, which can be used as a potential medicine for cardiovascular diseases.

show abstract

“…High activity of SOD in the group III may be a result of an adaptive cell mechanism, which was a result of the oxidative stress induced by the high-fat diet. It has been reported that oxidative stress increased SOD levels [22].…”

Section: Oxidative Stress and Antioxidant Capacitymentioning

confidence: 98%

Antihyperlipidemic, antioxidant and weightlowering effects of “Vitalplant”

et al. 2015

View full text Add to dashboard Cite

BACKGROUND: “VITALPLANT” medicinal plant mixture, aimed at body weight regulation and metabolism enhancement was formulated in order to be incorporated as an ingredient in functional food formulations on the basis of known biological activity of the alder buckthorn bark, peppermint, caraway and parsley. METHODOLOGY: The body weight-lowering potential, hypolipidemic effects and antioxidant activity of “Vitalplant” mixture were examined on five groups of male Wistar rats on different food regimes for 14 weeks. RESULTS: “Vitalplant” mixture supplementation caused an increase in food intake, but induced a decrease in body weight gain. The lipid status and atherogenic index (AI) were significantly improved in “Vitalplant” mixture supplemented hyperlipidemic (HF) groups in comparison to HF group. “Vitalplant” mixture was able to influence the activity of antioxidant enzymes and to protect erythrocytes of the rats fed the HF diet from oxidative damage, which was indicated by significantly lower malondialdehyde (MDA) levels in “Vitalplant”- HF groups in comparison to the HF group. CONCLUSION: “Vitalplant” mixture seemed to be beneficial for the reduction of body weight and improvement of antioxidant status of the erythrocytes, and its antihyperlipidemic property was highly active for enhancing the profile of plasma lipids in rats.

show abstract

Cholesterol-rich diets have different effects on lipid peroxidation, cholesterol oxides, and antioxidant enzymes in rats and rabbits

Cited by 122 publications

References 57 publications

Effect of High Fat Diet Without Cholesterol Supplementation on Oxidative Stress and Lipid Peroxidation in New Zealand White Rabbits

Effect of High Fat Diet Without Cholesterol Supplementation on Oxidative Stress and Lipid Peroxidation in New Zealand White Rabbits

The antioxidant activity and hypolipidemic activity of the total flavonoids from the fruit of Rosa laevigata Michx

Antihyperlipidemic, antioxidant and weightlowering effects of “Vitalplant”

Contact Info

Product

Resources

About