Cholesterol-Lowering Activity of the Major Polyphenols in Grape Seed

Ngamukote, Sathaporn; Mäkynen, Kittana; Thilawech, Thavaree; Adisakwattana, Sirichai

doi:10.3390/molecules16065054

Cited by 176 publications

(131 citation statements)

References 22 publications

Supporting

Mentioning

117

Contrasting

Order By: Relevance

“…These effects can be due to the combination of GS oil available to decreased absorbed crude fat. Also, Benzie (2003) and Ngamukote et al (2011) Abdallah et al (2017 who reported that GS extract has plenty of antioxidant substances that have decreasing effect on LDL and increasing effect on HDL and significant improvement in GSH-Px, SOD, TP, albumin and T3. Also, Elkomy and Elghalid, (2014) found that plasma TP, albumin and TAC were gradually increased while, plasma total lipids, cholesterol and lipid peroxidation activity and the ALT and AST enzymes activities were gradually and significantly decreased in MSS groups compared to the control.…”

Section: Blood Analysismentioning

confidence: 99%

Productive Performance, Blood Parameters and Immune Response of Broiler Chickens Supplemented With Grape Seed and Medicago Sativa as Natural Sources of Polyphenols

2018

EPSJ

View full text Add to dashboard Cite

ABSTRACT:A total number of 216 unsexed one day old Cobb broiler chicks were randomly divided to six dietary treatments with 6 replicated cages of 6 birds each to investigate the effect of grape seed (GS) and medicago sativa seed (MSS) as sources of natural polyphenols compared with Vitamin E (Vit. E) on productive performance, blood parameters and immune response of broiler chickens. The 1 st group was fed a basal diet without supplementation (control), while the 2 nd , 3 rd , 4 th , 5 th and 6 th groups were fed the basal diet supplemented with 200 IU Vit. E, 0.5, 1.0 gm GS powder, 0.5 and 1% MSS / Kg diet, respectively. Results showed that broilers fed basal diet supplemented with natural sources of polyphenols had greater body weight (BW), body weight gain (BWG) and feed intake and better feed conversion ratio (FCR), economical efficiency, production index compared to Vit. E and control groups. All supplementations decreased serum urea, creatinine, AST, ALT, total lipids, triglycerides, cholesterol, LDL and increased T3,T4, glucose, HDL, Alkaline phosphatase (ALP), total antioxidant capacity (TAOC), glutathione peroxidase (GPX), glutathione (GSH), superoxide dismutase (SOD), RBC's count, hemoglobin, packed cell volume (PCV), WBC's, and Lymphocytes, total protein (TP), β and γ-globulin, globulin, IgA, IgM, IgG, Lysozyme activity (LA), Bactericidal activity (BA), Lymphocyte transformation test (LTT), Phagocytic activity (PA), Phagocytic index (PI), interferon-gamma (IFNγ), interleukin-2 (IL2) and interleukin-10 (IL10) compared to control. All supplementations increased percentage of dressing and total edible parts compared with control. Moreover, all supplementations decreased total bacterial count, Salmonella, E.Coli and proteus compared to control. In conclusion, natural source of polyphenols either grape seed or medicago sativa seeds could be used safely to improve productive performance, economical efficiency and immune response of broiler chickens, but this experience needs to many studies.

show abstract

Section: Blood Analysismentioning

confidence: 99%

Productive Performance, Blood Parameters and Immune Response of Broiler Chickens Supplemented With Grape Seed and Medicago Sativa as Natural Sources of Polyphenols

2018

EPSJ

View full text Add to dashboard Cite

show abstract

“…This means SALE supplementation alone was not enough to lower cholesterol content to below control. Compounds that play a role in lowering cholesterol might be alkaloids and non-alkaloids (Santoso et al, 2010), saponins (Son et al, 2007), polyphenol (Ngamukote et al, 2011;Zang et al, 2006), flavonoid (Shrime et al, 2011). Patil et al (2010) reported that the reduction of cholesterol and triglycerides by alkaloids were in part caused by the reduction of lipogenic enzymes activities and increased bile acid excretion in feces.…”

Section: Levels Of Fat Protein and Cholesterol Meatmentioning

confidence: 99%

Effect of Sauropus Androgynus Leaves Extract (Sale) on Fat Deposition in Broiler Fed Low Protein Diets

Santoso

Kususiyah

Fenita

2013

J. Indonesian Trop. Anim. Agric.

View full text Add to dashboard Cite

ABSTRAKPenelitian ini dirancang untuk mengevaluasi efektivitas ekstrak daun katuk (EDK) untuk menurunkan penimbunan lemak pada broiler yang diberi pakan berprotein rendah. Delapan puluh empat broiler jantan dan betina (1:1) umur 20 hari didistribusikan ke dalam 7 kelompok perlakuan sebagai berikut: 1) Broiler dengan pakan mengandung 19% protein tanpa ekstrak daun katuk (EDK)/kg (P0); 2) Broiler dengan pakan mengandung 19% protein plus 4,5 g EDK/kg (P1); 3) Broiler dengan pakan mengandung 17% protein plus 4,5 g EDK/kg (P2); 4) Broiler dengan pakan mengandung 15% protein plus 4,5 g EDK/kg (P3); 5) Broiler dengan pakan mengandung 19% protein plus 9 g EDK/kg (P4); 6) Broiler dengan pakan mengandung 17% protein plus 9 g EDK/kg (P5); 7) Broiler dengan pakan mengandung 15% protein plus 9 g EDK/kg (P6). Hasil penelitian menunjukkan bahwa suplementasi ekstrak daun katuk dalam pakan berprotein rendah berpengaruh tidak nyata terhadap warna daging, cacat dada, bau karkas, dan fatty liver score (P>0,05) tetapi berpengaruh nyata terhadap cacat paha (P<0,01), warna kaki, rasa dan bau daging (P<0,05). Selain itu, suplementasi ekstrak daun katuk berpengaruh nyata terhadap kadar lemak (P<0,05) dan sangat nyata terhadap kadar kolesterol daging (P<0,01), tetapi berpengaruh tidak nyata (P>0,05) terhadap kadar protein dan komposisi asam lemak daging. Disimpulkan bahwa suplementasi ekstrak daun katuk pada dosis 9 g/kg pakan mampu menormalkan deposisi lemak pada broiler yang diberi pakan berprotein rendah. Ekstrak katuk juga mampu memperbaiki mutu karkas broiler. Kata kunci: esktrak daun katuk, penimbunan lemak, protein rendah, broiler ABSTRACTThe present study was designed to evaluate the effect of Sauropus Androgynus Leaves Extract (SALE) on broiler chickens fed low protein diets. Eighty four mixed broiler chickens (male:female = 1:1) aged 20 days were distributed to seven treatment groups as follows: 1) Broilers fed 19% protein without SALE (P0); 2) Broilers fed 19% protein plus 4.5 g SALE/kg (P1); 3) Broilers fed 17% protein plus 4,5 g SALE/kg (P2); 4) Broilers fed 15% protein plus 4.5 g SALE/kg (P3); 5) Broilers fed 19% protein plus 9 g SALE/kg (P4); 6) Broilers fed 17% protein plus 9 g SALE/kg (P5); 7) Broilers fed 15% protein plus 9 g SALE/kg (P6). Experimental results showed that supplementation of Sauropus androgynus extract to low protein diets had no effect on meat colour, haemorrhages scale in breast meat, and fatty liver score (P>0.05), but it significantly affected haemorrhages scale in thigh meat (P<0,01), shank colour, meat taste and flavour (P<0.05). In addition, supplementation of the extract significantly affected meat fat content (P<0.05) and meat cholesterol content (P<0.01), but it had no effect on meat protein content (P>0.05). It can be concluded that the leaves extract of Sauropus androgynus supplementation at level of 9 g/kg diets normalized fat deposition in broiler chickens fed low protein diets. SALE improved broiler meat qualities.

show abstract

“…Ngamukote et al (2011) [51] suggested that gallic acid, catechin, and epicatechin might bind to TDCA and thus modulate the concentration of that BA in the gastrointestinal tract. Another study conducted in rats indicated that some dietary polyphenols, e.g., catechin, might reduce fecal BA, DCA and LCA [3].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Raspberry pomace alters cecal microbial activity and reduces secondary bile acids in rats fed a high-fat diet

Fotschki

Juśkiewicz

Jurgoński

et al. 2017

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

ReuseUnless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. ÔØ Å ÒÙ×Ö ÔØRaspberry pomace alters cecal microbial activity and reduces secondary bile acids in rats fed a high-fat diet This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT Raspberry pomace alters cecal microbial activity and reduces secondary bile acids in rats fed a high-fat diet A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT ABSTRACTThe profile of bile acids (BA) largely depends on the enzymatic activity of the microbiota, but this can be modulated by the dietary addition of biologically active compounds, e.g., polyphenols and polyunsaturated fatty acids. The aim of this study was to examine the effect of dietary raspberry pomace as a rich source of biologically active compounds on microbial activity and the BA profile in the caecum of rats fed a high-fat diet.Wistar rats were fed the standard diet AIN-93, a high-fat diet or a modified high-fat diet enriched with 7% different types of processed raspberry pomaces produced by standard grinding and fine grinding, with or without seeds. Rats fed the high-fat diet for eight weeks showed some disorders in liver function and cecal BA, as manifested by an increased concentration of cholesterol, total BA in the liver and cholic, deoxycholic, and -muricholic acids in the cecal digesta. In general, irrespective of the type of raspberry pomace, these dietary preparations decreased liver cholesterol, hepatic fibroblast growth factor receptor 4, peroxisome proliferator-activated receptor alpha, cecal ammonia and favorable changed BA profile in the cecum. However, among all dietary pomaces, the finely ground preparation containing seeds had the greatest beneficial effect on the caecum by modulating bacterial activity and reducing the levels of secondary BA.

show abstract

Cholesterol-Lowering Activity of the Major Polyphenols in Grape Seed

Cited by 176 publications

References 22 publications

Productive Performance, Blood Parameters and Immune Response of Broiler Chickens Supplemented With Grape Seed and Medicago Sativa as Natural Sources of Polyphenols

Productive Performance, Blood Parameters and Immune Response of Broiler Chickens Supplemented With Grape Seed and Medicago Sativa as Natural Sources of Polyphenols

Effect of Sauropus Androgynus Leaves Extract (Sale) on Fat Deposition in Broiler Fed Low Protein Diets

Raspberry pomace alters cecal microbial activity and reduces secondary bile acids in rats fed a high-fat diet

Contact Info

Product

Resources

About