Cholesterol-free diet and the physiologic hyperlipidemia of pregnancy in familial hypercholesterolemia

Glueck, Charles J.; Christopher, C.; Tsang, Reginald C.; Mellies, Margot J.

doi:10.1016/0026-0495(80)90038-4

Cited by 26 publications

(6 citation statements)

References 17 publications

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“…Advice regarding low fat, high dietary soluble fibre, low glycemic index carbohydrate intake and ideal weight gain for pregnancy should be given by a dietician with experience in pregnancy nutrition. In pregnant women with heterozygous FH, a cholesterol-free diet lowered LDL-C levels by 33%, whereas a low-cholesterol diet lowered LDL-C levels by 14% [34]. Optimal weight gain recommendations based on maternal body mass index at the beginning of pregnancy have been recommended by the Institute of Medicine with lower gestational weight gain recommended for obese women [35].…”

Section: Dietmentioning

confidence: 99%

Management of familial hypercholesterolemia in pregnancy

Graham

Raal

2021

Current Opinion in Lipidology

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Purpose of review To highlight quandaries and review options for the management of familial hypercholesterolemia (FH) during pregnancy. Recent findings Women with FH face barriers to effective care and consequently face significant disease related long term morbidity and mortality. Pregnancy includes major maternal physiological changes resulting in exacerbation of maternal hypercholesterolemia compounded by the current practice of cessation or reduction in the dose of lipid-lowering therapy during pregnancy and lactation that may impact short and long term cardiac morbidity and mortality. Although lipoprotein apheresis is the treatment of choice for high- risk FH patients, reassuring safety evidence for the use of statins during pregnancy is mounting rapidly. However, it will be some time before subtle effects on the development of the offspring can be definitively excluded. Women with homozygous FH or with an established atherosclerotic vessel or aortic disease should be offered therapy with statins during pregnancy if lipoprotein apheresis is not readily available. Pregnancy outcomes tend to be favourable in women with FH. We have reviewed the currently available evidence regarding the risks and benefits of treatment options for FH during pregnancy.

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Section: Dietmentioning

confidence: 99%

Management of familial hypercholesterolemia in pregnancy

Graham

Raal

2021

Current Opinion in Lipidology

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“…But, high cholesterol during pregnancy can lead to pregnancy-induced hypertension, cardiovascular risk which can threaten the life of both the mother and child [65]. The additional increase in cholesterol during pregnancy occurs also in women with familial hypercholesterolemia, in both heterozygotic [66] and homozygotic forms [67]. In contrast, low cholesterol can lead to premature labor and low birth weight [47].…”

Section: Discussionmentioning

confidence: 99%

Biochemical variation and association of Maternal Lipid Profile with Body Mass Index during Pregnancy

Prakash

Pandeya

2019

WJGWH

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Background and objectives:The alteration of lipid profiles of healthy gestating women occurs with multiple physiological changes which may have subsequent risk associated with adverse pregnancy outcomes affecting both maternal and fetal health. Therefore, the objective of this study was focused to examine serum lipid profile and its correlation with body mass index in pregnant women and healthy non-pregnant women at Terai in Province No.2 of Nepal.

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“…Considerably less has been written on the signi icance and consequences of 'gestational familial hypercholesterolemia', and our knowledge of this metabolic peculiarity remains insuf icient [19][20][21][22][23]. The pathogenesis of GH is still poorly understood, although the placenta can use all the metabolic mechanisms of lipogenesis that have been described in non-pregnant adults [24][25][26].…”

Section: /)mentioning

confidence: 99%

Gestational hypercholesterolemia helps detect familial hypercholesterolemia and prevent late pregnancy complications

Hyánek¹,

Pehal²,

Dryahina³

et al. 2019

Clin J Obstet Gynaecol

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Introduction: In this retrospective study, we comment on the cause and diagnostic potential of the elevated serum total cholesterol and some non-cholesterol sterols in a population of healthy pregnant women from Prague, Czech Republic. Methods: Based on a total of 21,000 clinical biochemistry tests of healthy pregnant women with hypercholesterolemia observed during pregnancy, a testing group of 84 women with a total cholesterol (TC) above 7.0 mmol/l was established to analyze their non-cholesterol sterols (NCS) by Gas Chromatography-Mass Spectrometry. Lathosterol (Lat) and desmosterol (Des) were evaluated as markers of endogenous cholesterol synthesis, whereas campesterol (Cam) and sitosterol (Sit) were analysed as markers of intestinal absorption. Results: In the basic population, the frequency of gestational hypercholesterolemia with the serum TC levels > 7.0mmol/l was 1 to 136.The mean values were: TC 6.8 mmol/l, LDL-C 4.6 mmol/l, and HDL-C 2.2 mmol/l. In the selected testing group of 84, the mean values were: Lat 7.8+/-1.7 μmol/l, Des 4.7+/-0.9 μmol/l, Cam 9.8+/-2.6 μmol/l, and Sit 9.6+/-3.8 μmol/l. Lat correlated with TC (r = 0.53), LDL-C (r = 0.36), and non-HDL-C (r = 0.35). No such correlations were observed for Cam or Sit. Conclusion: Our fi ndings prove that gestational hypercholesterolemia is caused by increased endogenous cholesterol synthesis via lathosterol. Subsequently, we demonstrate how a single cholesterol test taken in the fi fth to sixth month gestation can effi ciently help detect familial hypercholesterolemia, and prevent related late pregnancy circulatory complications.

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Cholesterol-free diet and the physiologic hyperlipidemia of pregnancy in familial hypercholesterolemia

Cited by 26 publications

References 17 publications

Management of familial hypercholesterolemia in pregnancy

Management of familial hypercholesterolemia in pregnancy

Biochemical variation and association of Maternal Lipid Profile with Body Mass Index during Pregnancy

Gestational hypercholesterolemia helps detect familial hypercholesterolemia and prevent late pregnancy complications

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