Cholesterol feeding attenuates endothelium-dependent relaxation response to acetylcholine in the main pulmonary artery of chickens

Aksulu, Hakkı Engin; Cellek, Selim; Türker, R. K.

doi:10.1016/0014-2999(86)90456-5

Cited by 8 publications

(3 citation statements)

References 5 publications

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“…10 -13 ' 72 - 73 Alterations in smooth muscle contractility could, in turn, affect peripheral vascular resistance and systemic arterial pressure. Because the kidney has a unique role in the regulation of systemic blood pressure, it is also possible that cholesterol-induced alterations in renal function could be important in the pathogenesis of essential hypertension.…”

Section: Possible Impact Of Renal Abnormalities On Hypertension and Hmentioning

confidence: 99%

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Lipids and the kidney.

et al. 1990

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Section: Possible Impact Of Renal Abnormalities On Hypertension and Hmentioning

confidence: 99%

“…' 73 These data suggested that hypercholesterolemia may cause early alterations in renal vascular resistance that could participate in the pathogenesis of essential hypertension.…”

mentioning

confidence: 99%

Lipids and the kidney.

et al. 1990

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“…As will be discussed in detail in subsequent sections, one way that this is accomplished is by endothelial cell production of a non-prostaglandin substance that relaxes vascular smooth muscle, the so-called "Endothelium-Derived Relaxing Factor" (EDRF). 12 While much remains to be learned about EDRF, it is tempting to speculate that some of the vascular pathologies and derangements of cardiovascular function associated with disease states such as diabetes, 3 - 6 atherosclerosis, 7 -' 1 cerebral hemorrhage, 12 -' 4 hyperlipidemia, 15 - 17 and hypertension 18 " 21 could be due to impairment of endothelial cell function, and loss of the ability to produce EDRF or the inability of EDRF to affect vascular smooth muscle. The purpose of the present review is to describe our current understanding of the pharmacology and physiology of endothelium-dependent vascular reactivity, with emphasis on processes that appear to be mediated by EDRF.…”

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confidence: 99%

The Endothelium-Derived Relaxing Factor

Jackson¹

1989

J reconstr Microsurg

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Over the past 25 years, it has become clear that the vascular endothelium plays an important role in the function of the cardiovascular system. Most recently, it has been established that endothelial cells can determine or modulate the response of vascular smooth muscle cells to vasoactive stimuli, by production of a labile factor (or factors) that has been named the "Endothelium-Derived Relaxing Factor" (EDRF). While much remains to be learned about the pathways responsible for the production and the effects of EDRF, and its role in cardiovascular physiology, it is apparent that the loss of this endothelium-derived vasodilator can have profound effects on vascular pharmacology and physiology that could be important to the pathologies associated with disease states.

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Lipids and endothelium‐dependent vasodilation—A review

Lind

2002

Lipids

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Studies using both in vitro and in vivo techniques have repeatedly shown that endothelium-dependent vasodilation (EDV) is impaired in different forms of experimental as well as human hypercholesterolemia. Clearly this impaired EDV can be reversed by lowering cholesterol levels by diet or medical therapy. Competitive blocking of L-arginine, changes in nitric oxide synthase activity, increased release of endothelin-1, and inactivation of nitric oxide due to superoxide ions all contribute to the impairment in EDV during dyslipidemia. The oxidation of low density lipoprotein, with its compound lysophosphatidylcholine, plays a critical role in these events. However, data on the role of triglycerides and fat-rich meals regarding EDV are not so consistent as data for cholesterol, although a view that the compositions of individual fatty acids and antioxidants are of major importance is emerging. Thus, this review shows that while impaired EDV is a general feature of hypercholesterolemia, the mechanisms involved and the therapeutic opportunities available still have to be investigated. Furthermore, discrepancies regarding the role of triglycerides and fat content in food may be explained by divergent effects of different fatty acids on the endothelium.

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Cholesterol feeding attenuates endothelium-dependent relaxation response to acetylcholine in the main pulmonary artery of chickens

Cited by 8 publications

References 5 publications

Lipids and the kidney.

Lipids and the kidney.

The Endothelium-Derived Relaxing Factor

Lipids and endothelium‐dependent vasodilation—A review

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