Cholesterol efflux capacity in humans with psoriasis is inversely related to non-calcified burden of coronary atherosclerosis

Salahuddin, Taufiq; Natarajan, Balaji; Playford, Martin P.; Joshi, Aditya; Teague, Heather; Masmoudi, Youssef; Selwaness, Mariana; Chen, Marcus Y; Bluemke, David A.; Mehta, Nehal N.

doi:10.1093/eurheartj/ehv339

Cited by 69 publications

(68 citation statements)

References 15 publications

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“…Analysis of the plasma lipid showed a decrease in total cholesterol, cholesterol esters, and phospholipids (Supplemental Figure 2B). We also measured serum cholesterol efflux capacity, which is the ability of HDL to accept lipids for reverse cholesterol transport; this has been shown to be impaired in psoriasis patients (20) and accelerate atherosclerosis in humans (21). We found HDL efflux to be significantly decreased by 20% in the K14-Rac1V12 -/+ mice (Supplemental Figure 2C).…”

Section: K14-rac1v12mentioning

confidence: 83%

Chronic skin inflammation accelerates macrophage cholesterol crystal formation and atherosclerosis

Baumer¹,

Ng²,

Sanda³

et al. 2018

JCI Insight

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Section: K14-rac1v12mentioning

confidence: 83%

Chronic skin inflammation accelerates macrophage cholesterol crystal formation and atherosclerosis

Baumer¹,

Ng²,

Sanda³

et al. 2018

JCI Insight

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“…84,85 Increasing psoriasis severity has also been found to correlate negatively with HDL CEC in both adults and children with psoriasis. 85,86 Furthermore, HDL CEC is directly related to coronary artery disease burden in patients with psoriasis 87 and is suggested to be an important proxy for vascular disease.…”

Section: Cardiometabolic Diseasementioning

confidence: 99%

Psoriasis and comorbid diseases

Takeshita

Grewal

Langan

et al. 2017

Journal of the American Academy of Dermatology

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Psoriasis is a common chronic inflammatory disease of the skin that is increasingly being recognized as a systemic inflammatory disorder. Psoriatic arthritis is a well-known comorbidity of psoriasis. A rapidly expanding body of literature in various populations and settings supports additional associations between psoriasis and cardiometabolic disease, gastrointestinal disease, kidney disease, malignancies, infections, and mood disorders. The pathogenesis of comorbid disease in psoriasis patients remains unknown; however, shared inflammatory pathways, cellular mediators, genetic susceptibility, and common risk factors are hypothesized to be contributing elements. As additional psoriasis comorbidities continue to emerge, education of healthcare providers is essential to ensuring comprehensive medical care for patients with psoriasis.

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“…In CAV, coronary plaque is largely non-calcified and lipid-rich, with significant macrophage accumulation 24 ; this is similar to plaque composition in psoriasis patients, where reduced CEC was recently shown to be associated with non-calcified, lipid-rich plaque. 25 The importance of increased CEC in diseases such as psoriasis and CAV may be related to decreased macrophage foam cells in plaque in the context of significant background inflammation. Furthermore, pre-transplant CEC was recently tied to graft failure in kidney transplant recipients.…”

Section: Discussionmentioning

confidence: 99%

Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients

Javaheri

Molina

Zamani

et al. 2016

The Journal of Heart and Lung Transplantation

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BACKGROUND Cardiac allograft vasculopathy (CAV) is a major cause of mortality after cardiac transplantation. High-density lipoprotein (HDL) cholesterol efflux capacity (CEC) is inversely associated with coronary artery disease. In 2 independent studies, we tested the hypothesis that reduced CEC is associated with mortality and disease progression in CAV. METHODS We tested the relationship between CEC and survival in a cohort of patients with CAV (n = 35). Multivariable Cox proportional hazard models demonstrated that higher levels of CEC were associated with improved survival (hazard ratio 0.26, 95% confidence interval 0.11 to 0.63) per standard deviation CEC, p = 0.002). To determine whether reduced CEC is associated with CAV progression, we utilized samples from the Clinical Trials in Organ Transplantation 05 (CTOT05) study to determine the association between CEC and CAV progression and status at 1 year (n = 81), as assessed by average change in maximal intimal thickness (MIT) on intravascular ultrasound. RESULTS Patients who developed CAV had reduced CEC at baseline and 1-year post-transplant. We observed a significant association between pre-transplant CEC and the average change in MIT, particularly among patients who developed CAV at 1 year (β = −0.59, p = 0.02, R2 = 0.35). CONCLUSION Reduced CEC is associated with disease progression and mortality in CAV patients. These findings suggest the hypothesis that interventions to increase CEC may be useful in cardiac transplant patients for prevention or treatment of CAV.

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Cholesterol efflux capacity in humans with psoriasis is inversely related to non-calcified burden of coronary atherosclerosis

Abstract: NCT01778569.

Cited by 69 publications

References 15 publications

Chronic skin inflammation accelerates macrophage cholesterol crystal formation and atherosclerosis

Chronic skin inflammation accelerates macrophage cholesterol crystal formation and atherosclerosis

Psoriasis and comorbid diseases

Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients

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