Visual Abstract

and received payment for continuing medical education work related to psoriasis that was supported indirectly by Lilly and Ortho Dermatologics. 3.Dr. Tawakol reports grants from Genentech and Actelion for research outside the submitted work. 4.Dr. Powell-Wiley has received funding from the National Institutes of Health Intramural Research Program (ZIA HL006168).

Improvement in psoriasis skin disease severity was associated with improvement in aortic vascular inflammation by 18fluorodeoxyglucose positron emission tomography/computed tomography, with greater improvement in aortic vascular inflammation observed in those who had higher than 75% reduction in skin disease severity. These findings suggest that controlling remote target organ inflammation (eg, in the skin) may improve vascular diseases; however, randomized clinical trials are needed to confirm these findings.