Cholesterol crystals in synovial and bursal fluid

Lazarevic, Milenko B.; Skosey, John L.; Vitić, J; Mladenovic, Vlastimir; Myones, Barry L.; Popović, Jovan; Swedler, William I.

doi:10.1016/s0049-0172(05)80016-2

Cited by 24 publications

(5 citation statements)

References 23 publications

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“…The concentration of lipoproteins in synovial fluid from an RA patient increases by ∼50% over that in the serum from the same patient, in contrast to <10% in healthy synovial fluid (27, 28), possibly because lipoproteins can easily permeate the synovial membrane in RA joints (28). In addition, cholesterol crystals in synovial fluid are occasionally found in RA patients (29, 30). LDL can be oxidatively modified under inflammatory conditions in vivo (31).…”

Section: Discussionmentioning

confidence: 99%

Lectin‐like oxidized low‐density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low‐density lipoprotein in rheumatoid arthritis cartilage

Kakinuma¹,

Yasuda²,

Nakagawa³

et al. 2004

Arthritis & Rheumatism

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Section: Discussionmentioning

confidence: 99%

Lectin‐like oxidized low‐density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low‐density lipoprotein in rheumatoid arthritis cartilage

Kakinuma¹,

Yasuda²,

Nakagawa³

et al. 2004

Arthritis & Rheumatism

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“…Lazarevic eta/. (8) reported that rheumatoid arthritis patients had significantly decreased concentrations of total serum lipids, total serum cholesterol, cholesterol in low-density lipoprotein (LDL) and cholesterol in high-density lipoprotein (HDL) compared with healthy blood donors. However, the levels of lipids in plasma and erythrocyte membranes have not been simultaneously studied in rheumatoid arthritis patients.…”

Section: Introductionmentioning

confidence: 99%

Altered pattern of lipids in plasma and erythrocyte membranes of rheumatoid arthritis patients

Vijayakumar

Suresh

Manoharan

2005

Indian J Clin Biochem

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The present study has investigated the levels of lipids, lipoprotein cholesterol (HDL and LDL cholesterol), thiobarbituric acid reactive substances (TBARS) and vitamin E in plasma and erythrocyte membranes of twenty two clinically diagnosed adult rheumatoid arthritis patients and an equal number of age matched healthy subjects. The levels of lipids and lipoprotein cholesterol were markedly reduced in patients with rheumatoid arthritis as compared to healthy subjects. The altered lipid pattern may be related to decreased lipoprotein cholesterol, fatty acids and impairment in antioxidant defence mechanism.

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“…1,3,4,6,7 A case report of cholesterol in the synovial fluid in patients with rheumatoid arthritis without generalized lipid abnormalities also points to a local origin of cholesterol. 8 In case 3, the cholesterol may have formed as a result of degeneration of cells in the soft tissue of the arm. The patient had squamous cell carcinoma of the head and neck and had no evidence of autoimmune disorders.…”

Section: Discussionmentioning

confidence: 99%

Cholesterol Crystals Causing Falsely Elevated Automated Cell Count

Shen

Blair

2006

Am J Clin Pathol

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This is a report of 3 cases of body fluid containing numerous cholesterol crystals that caused falsely elevated cell counts on an automated cell counter. Two of the cases were pleural effusion fluid from patients with long-standing rheumatoid arthritis. Fluid in the third case was from upper extremity cystic lesions of a patient with squamous cell carcinoma of the head and neck. Microscopic examination revealed abundant cholesterol crystals in all fluid samples. In all 3 cases, initially, the automated cell counter reported very elevated WBC and RBC counts that were much higher than those from the manual count. This interference by cholesterol in the automated cell counter is discussed. In addition, possible pathophysiology of cholesterol formation in the body fluid is discussed and chylous and pseudochylous (chyliform) effusions are reviewed. Finally, the use of automated instruments in the evaluation of body fluid is reviewed.

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Cholesterol crystals in synovial and bursal fluid

Cited by 24 publications

References 23 publications

Lectin‐like oxidized low‐density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low‐density lipoprotein in rheumatoid arthritis cartilage

Lectin‐like oxidized low‐density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low‐density lipoprotein in rheumatoid arthritis cartilage

Altered pattern of lipids in plasma and erythrocyte membranes of rheumatoid arthritis patients

Cholesterol Crystals Causing Falsely Elevated Automated Cell Count

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