Cholesterol-Binding Reserve and Myocardial Infarction

Hsia, S.L.; Briese, Franklin W.; Hoffman, James E.

doi:10.1016/s0140-6736(76)91630-5

Cited by 13 publications

(2 citation statements)

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“…Our previous studies demonstrated that human serum can solubilize a measurable amount of additional cholesterol and this amount was designated serum cholesterol binding reserve (SCBR). SCBR was found to be decreased in patients with premature myocardial infarction (Hsia, Chao, Hennekens and Reader 1975;Hsia, Briese and Hoffman 1976), patients with diabetes mellitus (Hsia, Fishman, Briese, Christakis, Burr and Bricker 1978), and patients with the nephrotic syndrome (Perez, Levine, Gomez and Hsia 1979). Since the last two groups of patients have a high incidence of atherosclerotic complications, it is suggested that decreased SCBR may be a risk factor for the development of premature atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Serum Cholesterol Binding Reserve and High Density Lipoprotein Cholesterol in Patients on Maintenance Hemodialysis

Go¹,

Sl²,

Christakis³

et al. 1980

Horm Metab Res

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Serum cholesterol binding reserve (SCBR, the capacity of the serum to solubilize additional cholesterol), high density lipoprotein cholesterol (HDL . Ch) and serum levels of cholesterol and triglycerides were measured in 53 chronically uremic patients (40 men and 13 women) undergoing maintenance hemodialysis. The values were compared with those of controls (149 men and 28 women) matched for serum lipid levels. Hypertriglyceridemia and decreased HDL . Ch were observed among the patients, confirming previous reports. SCBR values of the patients were not significantly different from those of controls except in a small subgroup of uremic diabeties, whose SCBR values were markedly decreased. There was a positive correlation between SCBR and the duration for which the patients had been maintained by hemodialysis. The results suggest that patients with higher SCBR values have a better prospect for surviving long duration of hemodialysis.

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Section: Introductionmentioning

confidence: 99%

Serum Cholesterol Binding Reserve and High Density Lipoprotein Cholesterol in Patients on Maintenance Hemodialysis

Go¹,

Sl²,

Christakis³

et al. 1980

Horm Metab Res

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show abstract

“…Our recent studies have demonstrated that the human serum can solubilize a measurable amount of additional cholesterol, and that this amount, designated serum-cholesterol-binding reserve (SCBR), was significantly lower in patients with premature myocardial infarction [11,12], It was further shown that SCBR can be attributed to the cholesterol-solubilizing capacity of two lipoprotein sub fractions. one of which is from HDL, and the other from very-low-density lipoprotein (VLDL) [II], In the present study, we have investigated SCBR and serum lipid levels in patients with the nephrotic syndrome.…”

Section: Introductionmentioning

confidence: 99%

Serum-Cholesterol-Binding Reserve in Patients with the Nephrotic Syndrome

Pérez¹,

Levine²,

Gomez³

et al. 1979

Nephron

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Hyperlipidemia and premature atherosclerosis are known metabolic complications in patients with the nephrotic syndrome. In this study, we have measured serum levels of cholesterol, triglycerides and serum-cholesterol-binding reserve (SCBR) in 22 patients (14 men, 8 women) with the nephrotic syndrome and in 21 hyperlipidemic men who served as control subjects. Serum cholesterol levels were higher (p < 0.005) in patients when compared to those of controls while triglyceride levels did not differ significantly between the groups. SCBR levels were lower (p < 0.001) in the nephrotic subjects. The abnormally low SCBR values may be an important risk factor for atherosclerosis as suggested by previous studies in patients surviving premature myocardial infarction.

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Pediatric Nutritional Determinants of Chronic Diseases

Kafatos

Christakis

1981

Nutrition and Medical Practice

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Cholesterol-Binding Reserve and Myocardial Infarction

Cited by 13 publications

References 1 publication

Serum Cholesterol Binding Reserve and High Density Lipoprotein Cholesterol in Patients on Maintenance Hemodialysis

Serum Cholesterol Binding Reserve and High Density Lipoprotein Cholesterol in Patients on Maintenance Hemodialysis

Serum-Cholesterol-Binding Reserve in Patients with the Nephrotic Syndrome

Pediatric Nutritional Determinants of Chronic Diseases

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