Cholesterol and unsaturated fat diets influence lipid and glucose concentrations in rats

Adamopoulos, Panayotis; Papamichael, C.; Zampelas, Antonis; Moulopoulos, Spyros D.

doi:10.1016/0305-0491(95)02078-0

Cited by 26 publications

(17 citation statements)

References 17 publications

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“…3). Our findings are in agreement with those of other laboratories, which have reported that high-fat feeding induces insulin resistance in mice [1,11,19,43,48]. Multiple mechanisms have been proposed to explain the development of insulin resistance and mild hyperglycemia in the high-fat diet-fed model.…”

Section: Discussionsupporting

confidence: 95%

“…Several fat sources, such as pure cholesterol [23], vegetable oils [14], and animal sources such as lard [8], yolk egg [1], chicken skin [12], and butter [2] have been used in overload lipid-based studies. Meanwhile, there are currently no reports in the literature showing an animal model which used one of the fattiest animal food sources, the bovine brain, which contains about 65% of its calories from fat [44].…”

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confidence: 99%

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High-fat diet based on dried bovine brain: an effective animal model of dyslipidemia and insulin resistance

et al. 2011

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Currently, there are no reports in the literature demonstrating any animal model that ingests one of the fattiest animal food source, the bovine brain. We hypothesized that a high-fat diet (HFD), based on dried bovine brain, could be used to develop an animal model possessing a spectrum of insulin resistance-related features. The HFD was formulated with 40% dried bovine brain plus 16.4% butter fat, prepared in-house. Furthermore, the diet contained 52% calories as fat and 73% of total fatty acids were saturated. Swiss mice weighing about 40 g were assigned to two dietary groups (n=6/group), one group received a standard chow diet and the other was given HFD for 3 months. The body weight and biochemical parameters of the animals were measured initially and at monthly intervals until the end of the experiment. Animals fed on a HFD showed a significant increase in the body and adipose tissue weight, serum total cholesterol and triglyceride levels, when compared with mice fed on the control diet. Additionally, the HFD group showed higher circulating levels of liver transaminases, such as alanine aminotransferase and aspartate aminotransferase, compared with the control group. Finally, to illustrate the usefulness of this model, we report that the HFD induced mild hyperglycemia, fasting hyperinsulinemia, and increased the homeostasis model of assessment (HOMA-IR), in comparison with the control group. In conclusion, our results show that HFD, based on dried bovine brain, causes insulin resistance-related metabolic disturbances. Thus, this may be a suitable model to study disturbances in energy metabolism and their consequences.

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Section: Discussionsupporting

confidence: 95%

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confidence: 99%

High-fat diet based on dried bovine brain: an effective animal model of dyslipidemia and insulin resistance

et al. 2011

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“…These data indicate that different oils in varying quantities regulate APOA1 through differing mechanisms [201]. In contrast, HDL-C concentrations were significantly lower in male Wistar rats receiving C than in those fed 14 % olive or safflower oils [202]. In the presence of 1 or 2% C, the administration of different amounts of dietary OO (2% to 20%) resulted in decreased HDL-C levels compared to chow-fed rats [203,204].…”

Section: Dietary Fat and Cholesterol And Intervention Timementioning

confidence: 89%

HDL-Related Mechanisms of Olive Oil Protection in Cardiovascular Disease

Lou-Bonafonte¹,

Fitó²,

Covas³

et al. 2012

CVP

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The low incidence of cardiovascular disease in countries bordering the Mediterranean basin, where olive oil is the main source of dietary fat, and the negative association between this disease with high density lipoproteins has stimulated interest. This review summarizes the current knowledge gathered from human and animal studies regarding olive oil and high density lipoproteins. Cumulative evidence suggests that high density lipoprotein (HDL) cholesterol, and its main apolipoprotein A1, may be increased by consuming olive oil when compared with carbohydrate and low fat diets in humans. Conflicting results have been found in many studies when olive oil diets were compared with other sources of fat. The role of virgin olive oil minor components on its protective effect has been demonstrated by a growing number of studies although its exact mechanism remains to be elucidated. Dietary amount of olive oil, use of virgin olive oil, cholesterol intake, and physiopathological states such as genetic background, sex, age, obesity or fatty liver are variables that may offset those effects. Further studies in this field in humans and in animal models are warranted due to the complexity of HDL particles.

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“…It is also well known that in humans and animals, high levels of dietary polyunsaturated fatty acids (PUFAs) reduce HDL cholesterol (HDL-C) (13,20,21), a process that would further increase the risk of atherosclerosis. Therefore, an increased concentration of linoleate in the plasma lipids would be expected to correlate with an increased risk of coronary heart disease (CHD) (22)(23)(24)(25).…”

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confidence: 99%

α-Tocopherol protects against diet induced atherosclerosis in New Zealand white rabbits

Schwenke

Rudel

Sorci‐Thomas

et al. 2002

Journal of Lipid Research

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In this study, we asked the question "does ␣ -tocopherol supplementation prevent an increase in total plasma cholesterol (TPC) concentration and reduce the deposition of cholesterol in arterial plaques of rabbits fed atherogenic diets?" Isocaloric diets containing 0.1% cholesterol to induce atherosclerosis were enriched in one of three fats: saturated fats (SAT), monounsaturated fats (MONO), or n-6 polyunsaturated fats (POLY). Half of each of the three diets were supplemented with 2,500 IU ␣ -tocopherol/kg-diet. Unsupplemented diets contained 25 IU ␣ -tocopherol/kg-diet. Rabbits supplemented with ␣ -tocopherol had plasma ␣ -tocopherol concentrations 10-fold higher and an average TPC concentration 31% lower, P ‫؍‬ 0.017, than rabbits fed unsupplemented diets. Among the three fat-fed groups, the difference was greatest for the POLY fat fed group (54%, P ‫؍‬ 0.041). POLY fat-fed rabbits without ␣ -tocopherol supplementation had plasma HDL cholesterol concentrations that were less than half that of rabbits fed other fats, P р 0.0001. In general, differences in mean esterified artery cholesterol concentrations among the three fat-fed groups, with and without ␣ -tocopherol supplementation, paralleled differences in TPC concentration among the groups.This study suggests that for rabbits fed high pharmacological doses of ␣ -tocopherol, atherosclerosis can be diminished in situations where the plasma cholesterol concentrations are also significantly lower. -Schwenke, D. C., L. L. Rudel, M. G. Sorci-Thomas, and M. J. Thomas. ␣ -Tocopherol protects against diet induced atherosclerosis in New Zealand white rabbits.

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Cholesterol and unsaturated fat diets influence lipid and glucose concentrations in rats

Cited by 26 publications

References 17 publications

High-fat diet based on dried bovine brain: an effective animal model of dyslipidemia and insulin resistance

High-fat diet based on dried bovine brain: an effective animal model of dyslipidemia and insulin resistance

HDL-Related Mechanisms of Olive Oil Protection in Cardiovascular Disease

α-Tocopherol protects against diet induced atherosclerosis in New Zealand white rabbits

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