Cholesterol and serotonin indices in depressed and suicidal patients

Sarchiapone, Marco; Camardese, Giovanni; Roy, Alec; Casa, Silvia Della; Satta, M. A.; Gonzalez, Bienvenido; Berman, J; Risio, S. De

doi:10.1016/s0165-0327(99)00200-1

Cited by 61 publications

(37 citation statements)

References 8 publications

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“…Case-control and cross-sectional studies have demonstrated lower cholesterol levels in patients admitted following suicide attempts compared to those admitted without an attempt (Takei et al, 1994;Kunugi et al, 1997;Papassotiropoulos et al, 1999;Garland et al, 2000;Sarchiapone et al, 2001;Guillem et al, 2002;Kim et al, 2002;Lee and Kim, 2003). Comparisons of suicide attempters to well controls have yielded similar results (Gallerani et al, 1995;Alvarez et al, 1999;Sarchiapone et al, 2000;Atmaca et al, 2002b;Kim et al,, 2002;Tripodianakis et al, 2002;Lee and Kim, 2003).…”

Section: Introductionmentioning

confidence: 92%

Cholesterol and suicide attempts: A prospective study of depressed inpatients

Fiedorowicz

Coryell

2007

Psychiatry Research

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Low cholesterol levels have commonly been associated with various suicide measures. We sought to examine suicide attempts in a prospective sample of depressed patients that on prior analysis demonstrated an association between low cholesterol and subsequent suicide completions. Seventyfour inpatients with Research Diagnostic Criteria unipolar major depression, bipolar depression or schizoaffective depression entered a prospective follow-up study from 1978 -1981. Kaplan-Meier survival analysis and Cox regression were utilized to elucidate the relationship between cholesterol levels and subsequent severe suicide attempts as well as all suicide attempts regardless of severity. Attempts preceding index hospitalization and other lifetime attempts were evaluated crosssectionally. Low serum cholesterol levels did not predict subsequent suicide attempts. Contrary to our hypothesis, the high cholesterol group was associated with increased risk of suicide attempts on survival analysis in those less than median age. Nonetheless, in cross-sectional analysis, the low cholesterol group had more suicide attempts preceding index hospitalization and more remote lifetime attempts. The results from this prospective dataset do not support an association between low cholesterol and subsequent suicide attempts despite replicating the retrospective findings of previous case-control and cross-sectional studies.

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Section: Introductionmentioning

confidence: 92%

Cholesterol and suicide attempts: A prospective study of depressed inpatients

Fiedorowicz

Coryell

2007

Psychiatry Research

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“…Numerous studies showed lower cholesterol levels in patients hospitalized after suicide attempt as compared to non attempters hospitalized patients (Sarchiapone et al, 2001;Guillem et al, 2002;Kim et al, 2002) with remained significant difference in men, but not in women, after gender stratification (DiazSastre et al, 2007).On the other hand, there are some other studies showing no relationship between low cholesterol levels and suicide attempt Tsai et al, 2002;Deisenhammer et al, 2004;Fiedorowizc et al, 2007) and even one recent study demonstrating higher cholesterol level in patients with suicide attempt in the past year (Brunner et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Differences in cholesterol and metabolic syndrome between bipolar disorder men with and without suicide attempts

Vuksan-Ćusa

Marčinko

Nađ

et al. 2009

Acta Neuropsychiatr.

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Patient with mental illnesses such as schizophrenia and bipolar disorder have an increased prevalence of metabolic syndrome (MetS) and its components compared to general population. Among psychiatric disorders, bipolar disorder ranks highest in suicidality with a relative risk ratio of completed suicide of about 25 compared to the general population.Regarding the biological hypotheses of suicidality, low blood cholesterol level has been extensively explored, although results are still conflicting. The aim of this study was to investigate whether there were differences in the serum cholesterol levels in hospitalized bipolar disorder men patients with history of suicide attempts (N=20) and without suicide attempts (N=20). Additionally, we investigated if there were differences in the prevalence of MetS according to NCEP ATP-III criteria in these two groups of patients. Results of the study indicated significantly lower serum cholesterol levels (p=0.013) and triglyceride levels (p=0.047), in the bipolar disorder men with suicide attempts in comparison to bipolar disorder men without suicide attempts. The overall prevalence of MetS was 11/40 (27.5%). On this particular sample it was higher in the non-attempters 8/20 (40.0%) than in attempters 3/20 (15.0%) bipolar men group, but without statistical significance. Lower concentrations of serum cholesterol might be useful biological markers of suicidality in men with bipolar disorder.

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“…The growing number of studies examining the relationship between suicide and lipid metabolism are based upon studies suggesting that cholesterol-lowering procedures may increase the risk of death due to suicide or impulsive-aggressive behavior [1][2][3]. Low cholesterol values have been associated with a variety of psychiatric-disorder-related suicide and impulsive-aggressive behaviors, e.g.…”

Section: Introductionmentioning

confidence: 99%

Serum Leptin and Cholesterol Values in Suicide Attempters

Atmaca¹,

Kuloğlu²,

Tezcan³

et al. 2002

Neuropsychobiology

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The growing number of studies examining the relationship between suicide and lipid metabolism are based upon studies suggesting that cholesterol-lowering procedures may incease the risk of death due to suicide or impulsive-aggressive behavior. Leptin seems to be strongly associated with lipid metabolism. In the present study, serum total cholesterol and leptin levels were compared in 24 suicide attempters and 24 healthy controls. The patients with suicide attempts had significantly lower serum cholesterol and leptin levels than controls. There was a positive correlation between cholesterol and leptin levels in both groups. Our results suggest that suicide attempts seem to be associated with decreased serum cholesterol and leptin levels.

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Cholesterol and serotonin indices in depressed and suicidal patients

Cited by 61 publications

References 8 publications

Cholesterol and suicide attempts: A prospective study of depressed inpatients

Cholesterol and suicide attempts: A prospective study of depressed inpatients

Differences in cholesterol and metabolic syndrome between bipolar disorder men with and without suicide attempts

Serum Leptin and Cholesterol Values in Suicide Attempters

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