Cholestatic hepatitis due to Ecballium elaterium ingestion

Bizid, S.; Mériam, Sabbah; Msakni, Issam; Slimene, Baha Ben; Mohamed, Gamal A.; Bouali, Riadh; Abdallah, H. Ben; Abdelli, N

doi:10.1016/j.clinre.2014.11.004

Cited by 5 publications

(3 citation statements)

References 9 publications

(6 reference statements)

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“…abdominal pain, acute rectorrhagia, acute colitis, bloody diarrhoea, vomiting) following ingestion of C. colocynthis have been reported in medical bibliography . Gastrointestinal (such as vomiting) and respiratory (such as dyspnoea and severe oedema of palate and uvula) disturbances, and a case of cholestatic hepatitis due to E. elaterium ingestion have been reported . The membranolytic activity of saponin (an ingredient of the pulp extract) is believed to be the main pathophysiological mechanism for intestinal damage from the ingested fruit of C. colocynthis .…”

contrasting

confidence: 63%

Medical toxicology in the Old Testament. The poisonous pottage

Mazokopakis

Karagiannis

2017

Internal Medicine Journal

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contrasting

confidence: 63%

Medical toxicology in the Old Testament. The poisonous pottage

Mazokopakis

Karagiannis

2017

Internal Medicine Journal

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“…It has been known in Tunisia as 'Feggous elhemir' , traditionally consumed as food in infusion, mixture of fruit or even in aerosol in cases of fever or flu (Bizid et al, 2014) and used as natural remedy with therapeutic activities against a wide range of aliment's pathogens (Boukef, 1986). The fruit juice of this species has traditionally been used in the treatment of acute and chronic jaundice, rhinosinusitis, and sinusuitis (Salhab, 2013;Sargin et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Solvent extraction effects on phytochemical constituents profiles, antioxidant and antimicrobial activities and functional group analysis of Ecballium elaterium seeds and peels fruits

et al. 2017

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Ecballium elaterium is a perennial herb with multiple medicinal properties. It was widely used in folk medicine as cathartic, anti-inflammatory and analgesic agents. The present study was devoted to investigate the effect of diethyl ether, acetone, and methanol solvent on the extraction, phytochemicals profiles, antioxidant and antimicrobial activities of Ecballium elaterium seeds and peels fruits. The total phenolic, flavonoid, flavonol, condensed tannins and carotenoids contents were estimated. Maximum phenolic (107 ± 4 mg GAE/g) and flavonoid (18 ± 0 mg QE/g) contents were also found in the methanol peels fruits extract. Results showed that methanol peels fruits extract have the highest antioxidant activity with IC 50 values of 1.2 ± 0.1 and 1 ± 0 mg/mL for DPPH and ABTS, respectively, and EC 50 value of 1040 ± 5 mg/mL for reducing power assays. Acetone and diethyl ether peels fruits extracts showed the best antibacterial agents especially against Micrococcus luteus, however no antifungal activity was observed. Spectral data of FT-IR analysis of Ecballium elaterium seeds and peels fruits extracts revealed the presence of functional groups such as ─DH, C─H, C─D and C=D. Due to their high antioxidant and antibacterial activities, E. elaterium seeds and peels fruits extracts have promising potential as future natural antioxidant and antibacterial agents in food industry.Keywords: Ecballium elaterium; solvent effects; phytochemical contents; antioxidant and antimicrobial properties; FT-IR analysis.Practical Application: Ecballium elaterium seeds and peels fruits can be potentially used as natural antioxidant and antibacterial inhibitor.

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“…It has large, juicy, berry-like, and ovate-oblong fruits that detach themselves explosively at maturity, scattering seeds and juice. E. elaterium is well known as a medicinal plant in Tunisia, frequently consumed in infusion, mixture of fruit or even in aerosol in cases of fever or flu (Bizid et al, 2014). This plant has been widely used in traditional medicine to treat various health disorders and diseases, including constipation, rheumatism, and jaundice (Toker et al, 2003;Attard et al, 2005;Bohlooli et al, 2012), hepatoprotective and proapoptotic effect (El Naggar et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Nutritional, phytochemical and antioxidant evaluation and FT-IR analysis of freeze dried extracts of Ecballium elaterium fruit juice from three localities

et al. 2016

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This study was designed to investigate chemical composition, the total phenolic content, flavonoid content, antioxidant activity and to analyze through FT-IR spectroscopy method the freeze-dried extract of Ecballium elaterium fruit from three different localities. The highest level of phenolic and flavonoid contents was recorded for the fruit juice from the Cap-Bon region, with 106.4 ± 0.4 mg GAE/g and 6.5 ± 0.2 mg QE/g, respectively. Antioxidant activity varied in dose-dependent manner with IC 50 values for DPPH scavenging of the freeze-dried fruit juice extracts from Cap-Bon, Kef and Sidi Bouzid were 38.6 ± 0.2, 50.1 ± 0.7, and 50.7 ± 0.2 µg/mL, respectively. The results from the FRAP test showed that the freeze-dried extracts of Cap-Bon exhibited potent activity, followed by those from Kef and Sidi Bouzid. Similar trend were revealed for ABTS•+ test, with the fruit juice extract from Cap-Bon (IC 50 = 0.6 ± 0.0 mg/mL). Furthermore, a good positive correlation was observed between the total phenols and three assays, especially DPPH. The freeze-dried extracts of fruit juice from Cap-Bon showed strong ability to act as antioxidants and can be considered as promising natural source of bioactive compounds. FT-IR analysis of each freeze-dried extract confirmed its richness on polyphenols and biological active functional groups.

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Cholestatic hepatitis due to Ecballium elaterium ingestion

Cited by 5 publications

References 9 publications

Medical toxicology in the Old Testament. The poisonous pottage

Medical toxicology in the Old Testament. The poisonous pottage

Solvent extraction effects on phytochemical constituents profiles, antioxidant and antimicrobial activities and functional group analysis of Ecballium elaterium seeds and peels fruits

Nutritional, phytochemical and antioxidant evaluation and FT-IR analysis of freeze dried extracts of Ecballium elaterium fruit juice from three localities

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