Cholelithiasis in the Ætiology of Gallbladder Neoplasms

Hart, Jacob; Modan, Baruch; Shani, Michal

doi:10.1016/s0140-6736(71)91661-8

Cited by 73 publications

(33 citation statements)

References 8 publications

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“…Devido às característi-cas clínicas inespecíficas e por sintomas ausentes no cân-cer precoce, esta neoplasia é freqüentemente diagnosticada em estágio tardio, com um prognóstico extremamente reservado e com uma taxa de sobrevida de cinco anos de aproximadamente 5% na maioria das séries. O resultado do seu tratamento está diretamente relacionado com o estadiamento, obtendo-se melhores resultados com tumor em estágio precoce, o qual em um terço dos casos é um achado incidental após colecistectomia por doença benigna 9 4 . Tem sido demonstrado que a incidência do câncer da vesícula biliar é maior nos países prevalentes em colelitíase 11,13 .…”

Section: Resultsunclassified

“…Devido às características clínicas inespecíficas e sintomas ausentes no câncer precoce, o diagnóstico só é possível em estágio avançado, quando o prognóstico é reservado, com índice de sobrevida em cinco anos de aproximadamente 5% na maioria das séries estudadas 3,4 .…”

Section: Introductionunclassified

“…Diferentes estudos mostram que a maioria dos pacientes com câncer da vesícula apresenta colelitíase e sofre da doença por um período de tempo considerável antes do diagnóstico de câncer [4][5][6] .…”

Section: Introductionunclassified

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Colelitíase e câncer de vesícula biliar

Torres

Caldas

Azevedo

et al. 2002

Rev. Col. Bras. Cir.

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OBJETIVO: O presente estudo tem por objetivo analisar os achados histológicos da vesícula biliar de pacientes submetidos à colecistectomia eletiva no Hospital Universitário Presidente Dutra, São Luís-MA. MÉTODO: Foram avaliados 2.008 pacientes, 359 do sexo masculino (17,9%) e 1.649 do sexo feminino (82,1%), com média de idade de 46,3 anos, operados no período de janeiro de 1990 a dezembro de 1998. A vesícula biliar, imediatamente após a colecitectoma era aberta e examinada macroscopicamente pelo cirurgião e em seguida enviada para exame histopatológico. RESULTADOS: A prevalência de câncer da vesícula biliar foi de 2,3 % (46 pacientes). Trinta e três pacientes (71,7%) apresentavam idade superior a 60 anos. CONCLUSÕES: Os autores concluem que a colecistectomia profilática eletiva deve ser realizada em pacientes assintomáticos com colelitíase, com idade superior a 60 anos e em boas condições cirúrgicas.

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Section: Resultsunclassified

Section: Introductionunclassified

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Colelitíase e câncer de vesícula biliar

Torres

Caldas

Azevedo

et al. 2002

Rev. Col. Bras. Cir.

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“…The association between gallbladder cancer and chronic inflammation due to gallstones has been mentioned in various studies since 1861. [13][14][15] Inflammation of the gallbladder wall is also seen in chronic inflammatory conditions, and found usually to be non-specific. 8 Gallstones are detected in 54-97% of gallbladder cancers.…”

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confidence: 99%

“…Interestingly, chronic cholecystitis has been shown to be the most common diagnosis in studies researching the association with UPGC, a finding confirmed in our study with a prevalence of 96.3%. 3,13 Ideally, a minimum of several-thousand cholecystectomy cases are needed to identify a possible association between chronic cholecystitis and UPGC due to the considerable difference between the incidence of chronic cholecystitis and that of gallbladder cancer. More extensive studies are required to evaluate this correlation.…”

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confidence: 99%

Incidental findings during routine pathological evaluation of gallbladder specimens: review of 1,747 elective laparoscopic cholecystectomy cases

Başak

Hasbahçeci

Canbak

et al. 2016

annals

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INTRODUCTION Cholecystectomy for benign gallbladder diseases can lead to previously undiagnosed gallbladder cancer during histopathological evaluation. Despite some controversy over its usefulness, histopathological evaluation of all gallbladder specimens is common in most hospitals. We evaluated the results of routine pathology of the gallbladder after cholecystectomy for benign gallbladder diseases with regard to unexpected primary gallbladder cancer (UPGC). METHODS Patients undergoing cholecystectomy because of benign gallbladder diseases between 2009 and 2013 were enrolled in this study. All gallbladder specimens were sent to the pathology department, and histopathological reports were examined in detail. The impact of demographic features on pathological diagnoses and prevalence of UPGC assessed. Data on additional interventions and postoperative survival for patients with UPGC were collected. RESULTS We enrolled 1,747 patients (mean age, 48.7±13.6 years). Chronic cholecystitis was the most common diagnosis (96.3%) and was associated significantly with being female (p=0.001). Four patients had UPGC (0.23%); one was stage T3 at the time of surgery, and the remaining three cases were stage T2. CONCLUSIONS Routine histopathological examination of the gallbladder is valuable for identification of cancer that requires further postoperative management.

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