Cholelithiasis: a complication of cardiac valve surgery in children

Williams, H. James; Johnson, K. W.

doi:10.1007/bf01002298

Cited by 7 publications

(4 citation statements)

References 7 publications

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“…Gallstone disease after prosthetic valve surgery has been attributed to haemolysis. 5 Cardiac surgery with a heart-lung machine also produces haemolysis, contributing to bile stone formation. 6 Systemic inflammatory response syndrome occurring after cardiac surgery with extracorporal circulation might also have lithogenic potential comparable with sepsis.…”

Section: Discussionmentioning

confidence: 99%

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Cholelithiasis in children with CHD: is it a problem?

2016

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Despite an accumulation of risk factors, prevalence of gallstones is not as high as expected in children with CHD. Open-heart surgery with a heart-lung machine plays a minor role as an aetiological factor. In about half of the cases, cholelithiasis is an incidental finding and patients stay asymptomatic. Prophylactic administration of ursodeoxycholic acid is not indicated in children undergoing open-heart surgery for CHDs. Biliary surgery is reserved for patients with recurrent symptoms or cholestasis. In children with CHD, cholelithiasis is a minor and manageable co-morbid condition.

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Section: Discussionmentioning

confidence: 99%

“…An accumulation of risk factors can be found, especially in the postoperative period after surgical correction of CHDs. Gallstone disease after prosthetic valve surgery has been attributed to haemolysis 5 . Cardiac surgery with a heart–lung machine also produces haemolysis, contributing to bile stone formation 6 .…”

Section: Discussionmentioning

confidence: 99%

Cholelithiasis in children with CHD: is it a problem?

2016

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“…15% of patients with gallstones under the age of 18 are infants [10]. Multiple risk factors have been associated with the gallstones' formation including prematurity [11], hemolytic disorders [12], gastrointestinal conditions like intestinal resection [13,14] and Crohn's disease [14,15], hepatobiliary issues like biliary tree anomalies [16], cirrhosis [17] or Wilson's disease [18], pulmonary conditions like bronchopulmonary dysplasia [19], and cystic fibrosis [20], as well as diuretic [21] or antibiotic [22] therapy, sepsis [19], phototherapy, TPN [14], and cardiac surgery [23][24][25]. Risk factors for gallstone development are present in around 70% of infants with cholelithiasis [10,26], most frequently heart surgery, TPN, and medicines [10].…”

Section: Case Reportmentioning

confidence: 99%

An Uncommon Case in a Healthy Infant: A Case of Infantile Cholelithiasis

Marathum Palli

2023

Dubai Med J

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Cholelithiasis or Gallstone disease is relatively rare in children and is an unusual finding in infancy. This is a case report of a healthy 4-month-old baby who presented with an inconsolable cry, irritability, and poor feeding, the baby was discovered to have cholelithiasis by abdominal ultrasonography. There were no risk factors for cholelithiasis in this baby except for neonatal hyperbilirubinemia, which required phototherapy. Conservative management was given to the baby, and follow-up showed spontaneous resolution of gallstones. This case highlights the importance of ultrasonography in the pediatric emergency.

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“…The patient is now 3 years old; he has no signs or symptoms referable to cholelithiasis and has required no specific intervention. 4) developed, which required a two-day course of phototherapy. The karyotype of peripheral lymphocytes was 47,XY+21.…”

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confidence: 99%

Cholelithiasis in Infants with Down Syndrome

Aughton

Gibson

Cacciarelli

1992

Clin Pediatr (Phila)

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Only four cases of cholelithiasis have been reported in patients with Down syndrome and none in Down syndrome infants. The cases of three Down syndrome infants (all males) with cholelithiasis are reported. Each exhibited different fetal complications, and in each, Down syndrome was diagnosed at birth. Gallstones apparently were congenital (a rarity) in one infant, since they were detected on the first day of life. Cholelithiasis was an incidental finding in another of the infants when, at 12 weeks old, he had renal ultrasonography because of a urinary tract infection. The third infant was 4 months old when sonographic studies revealed a gallstone. Despite the confirmation of cholelithiasis in all three infants, none has since had any signs or symptoms that suggest the need for intervention. Cholelithiasis is probably more common in Down syndrome infants than has been supposed, but whether Down syndrome infants with gastrointestinal (GI) malformations are more likely to have gallstones than are children with similar GI malformations but with normal karyotypes is unknown.

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Cholelithiasis: a complication of cardiac valve surgery in children

Abstract: Gallstone formation complicating cardiac valve replacement has been amply documented in adults. Two children who developed gallstones shortly after cardiac valve surgery are reported.

Cited by 7 publications

References 7 publications

Cholelithiasis in children with CHD: is it a problem?

Cholelithiasis in children with CHD: is it a problem?

An Uncommon Case in a Healthy Infant: A Case of Infantile Cholelithiasis

Cholelithiasis in Infants with Down Syndrome

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