Choledochal Cyst with Carcinoma of the Intrahepatic Bile Ducts and Pancreatic Ducts

Dexter, David F.

doi:10.1038/bjc.1957.3

Cited by 37 publications

(6 citation statements)

References 6 publications

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“… Four cases of congenital choledochal cyst associated with pancreatic carcinoma have been reported, in two men and two women, aged 15–34 years. All four pancreatic carcinomas were located in the head of the pancreas . In one of these four patients, there appeared to be a long common channel at autopsy.…”

Section: Discussionmentioning

confidence: 90%

Carcinoma of the pancreas associated with anomalous junction of pancreaticobiliary tracts: Report of two cases and review of the literature

Kuga

Yamaguchi

Shimizu

et al. 1998

Journal of Hepato-Biliary-Pancreatic Surgery

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We report two cases of carcinoma of the pancreas with anomalous junction of the pancreaticobiliary tracts. A 71-year-old Japanese woman had obstructive jaundice. Ultrasonography showed a hypoechoic mass in the pancreatic head and computed tomography demonstrated a low-density nodule in the pancreatic head. Endoscopic retrograde cholangiopancreatography displayed a double duct sign and an anomalous junction of the pancreaticobiliary tracts. The patient underwent a pancreatoduodenectomy. The histopathologic diagnosis of the resected specimen was adenocarcinoma of the pancreatic head. A 56-year-old Japanese man also developed obstructive jaundice. Ultrasonography and computed tomography showed a huge mass almost replacing the whole pancreas and involving the superior mesenteric artery, splenic artery, splenic vein, and portal vein. Multiple hepatic metastases and peritoneal dissemination were present. Endoscopic retrograde cholangiopancreatography demonstrated an anomalous junction of the pancreaticobiliary tracts. The patient died of hemorrhage from esophageal varices. We discuss the relationship between the anomalous junction of the pancreaticobiliary tracts and pancreatic carcinoma.

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Section: Discussionmentioning

confidence: 90%

Carcinoma of the pancreas associated with anomalous junction of pancreaticobiliary tracts: Report of two cases and review of the literature

Kuga

Yamaguchi

Shimizu

et al. 1998

Journal of Hepato-Biliary-Pancreatic Surgery

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“… Complication of biliary tract ca. Treatment Survival time (month) 1 Dexter [19] ### 22F B Ib Head Pap. ca.…”

Section: Discussionmentioning

confidence: 99%

A case report of gallbladder cancer and pancreas cystic neoplasm associated with pancreaticobiliary maljunction

Sato

Ito

Masaki

et al. 2021

International Journal of Surgery Case Reports

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Introduction and importance Pancreaticobiliary maljunction (PBM) is a rare congenital anomaly that is frequently associated with carcinoma of the biliary tract. However, there is still no clear evidence that PBM is associated with pancreatic tumors. Here we describe a case of gallbladder cancer and intraductal papillary mucinous neoplasm (IPMN) that is associated with PBM. Case presentation A 72-year-old man underwent a cholecystectomy with hepatectomy (S4a + S5) and regional lymph node dissection for gallbladder adenocarcinoma invading the front lobe branch of the hepatic artery. A pylorus-preserving pancreaticodudenectomy was also performed for pancreatic IPMN. Clinical discussion Presence of mucin type 6 (MUC6) -positive pyloric gland metaplasia in both the dilated pancreatic duct and the gallbladder background mucosa suggests that pancreatic IPMN and gallbladder cancer may have a common phenotypic origin. Additionally, analysis of 41 reported cases of pancreatic cancer associated with PBM revealed that in all metachronous multiple cancer cases, biliary tract cancer preceded the pancreatic cancer with congenital biliary dilatation accompanied by PBM. The analysis also revealed an increased proportion of pancreatic cancer cases with PBM in patients who had not undergone a flow diversion procedure located in pancreatic head. Conclusion We show an interesting relationship between pancreatic/gallbladder cancer and PBM. More comprehensive evaluations of the whole pancreaticobiliary system in follow-up of patients with PBM is required to understand the full extent of this relationship.

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“…There are only 12 reported cases of pancreatic cancer occurring in association with a choledochal cyst or PBM (Table 1). [5][6][7][8][9][10][11][12][13][14][15] These patients consisted of seven women and five men ranging in age from 15 to 75 years (mean 44.3 years). They were younger in age and the frequency was higher in women than in patients with the more common type of pancreatic cancer because choledochal cyst is most often encountered in young women.…”

Section: Discussionmentioning

confidence: 99%

Carcinoma Arising in the Pancreas 17 Years After Primary Excision of a Choledochal Cyst: Report of a Case

Eriguchi¹,

Aoyagi²,

Okuda³

et al. 2001

Surgery Today

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We report herein the case of a 42-year-old woman in whom a pancreatic carcinoma was found 17 years after excision of a choledochal cyst with Roux-en-Y hepaticojejunostomy. Although the incidence of biliary carcinoma associated with choledochal cyst is high, reports of cancer developing in the remaining intrapancreatic biliary tract or pancreas in patients who have previously undergone primary excision of a choledochal cyst are extremely rare. Long-term follow-up is recommended even for patients who have undergone excisional surgery for a choledochal cyst, in consideration of the possibility that cancer associated with the intrapancreatic biliary tract or pancreas may develop.

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Choledochal Cyst with Carcinoma of the Intrahepatic Bile Ducts and Pancreatic Ducts

Abstract: Images Figs. 7-9 Figs. 4-6 Figs. 2-3 Fig. 1

Cited by 37 publications

References 6 publications

Carcinoma of the pancreas associated with anomalous junction of pancreaticobiliary tracts: Report of two cases and review of the literature

Carcinoma of the pancreas associated with anomalous junction of pancreaticobiliary tracts: Report of two cases and review of the literature

A case report of gallbladder cancer and pancreas cystic neoplasm associated with pancreaticobiliary maljunction

Carcinoma Arising in the Pancreas 17 Years After Primary Excision of a Choledochal Cyst: Report of a Case

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