Cholecystectomy, peptic ulcer disease and the risk of adenocarcinoma of the oesophagus and gastric cardia

Abstract

Cholecystectomy, despite its effect on the composition of gastric juice, does not appear to increase the risk of adenocarcinoma of the oesophagus or gastric cardia. While the data do not contradict a protective effect of H. pylori, the results are also consistent with absence of such an effect.

Cholecystectomy and the risk of alimentary tract cancers: A systematic review

“…Two case control studies [20,21] with 321 cases between them and one cohort study [22] based on 91 cases, found that cholecystectomy, despite its effect on gastric juice did not appear to increase the risk of oesophageal adenocarcinoma. By contrast, two cohort studies [23,24] based on 179 cases, found a moderate association between cholecystectomy and subsequent oesophageal adenocarcinoma, however, the absolute risk was found to be small.…”

“…Two case control [20,21] and one cohort study [28] based on a total of 478 cases found that prior cholecystectomy was not associated with an increased risk of gastric cardia cancer. The results from a meta-analysis [25] which included two studies specific for gastric cardia cancer [20,28] found that cholecystectomy was not associated with risk of gastric cardia cancer(SRRs = 0.87, 95%CI: 0. 65-1.17).…”

“…Descriptive characteristics of studies on the association between cholecystectomy and Oesophageal Adenocarcinoma are shown in Table 1. Two case control [20,21] and three cohort studies [23,24,26] based on 618 cases found that cholecystectomy was not associated with an increased risk of oesophageal squamous cell carcinoma. The results from a metaanalysis, which included some of these studies, confirmed the null association (SRRs = 0.92, 95%CI: 0.80-1.06), which was independent of study location or study design [25] .…”

Comparison of comorbidity prevalence in oesophageal and gastric carcinoma patients

“…Data were derived from the population-based Eindhoven Cancer Registry, which covers approximately two million inhabitants in the southeast of The Netherlands [5]. They are served by 16 community hospitals and two large radiotherapy institutes that collaborate with the Cancer Registry within the framework of the Comprehensive Cancer Centre South, IKZ.…”

“…gastro-oesophageal junction (GOJ)] adenocarcinomas in The Netherlands has been increasing during past decades, especially in males [1][2][3][4][5]. Causal factors underlying the upward trend in incidence in GOJ adenocarcinomas are not yet elucidated.…”