Cholangiocarcinoma of the liver:Case report with seven-year survival, with review of the literature on primary liver tumors and hepatic resections

Rockwell, George E.; Baker, Joel W.; Lasersohn, Jack T.

doi:10.1002/1097-0142(196608)19:8<1177::aid-cncr2820190821>3.0.co;2-1

Cited by 16 publications

(3 citation statements)

References 33 publications

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“…If tumor is still limited in one of the hepatic ducts, lobectomy is possible,47 and a 7 year survival has been recorded. 76 Resection of hilar carcinoma is feasible if it is still small.'." Even if surgical intervention is not indicated, biliary drainage alleviates jaundice and prolongs survival in the hilar type.…”

Section: A N C E R J U N U U R Y 1977mentioning

confidence: 99%

Clinical aspects of intrahepatic bile duct carcinoma including hilar carcinoma.A study of 57 autopsy-proven cases

Okuda

Kubo

Okazaki

et al. 1977

Cancer

249

116

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The clinical features of 57 autopsied cases of intrahepatic bile duct carcinoma including 28 cases of the peripheral type (cholangiocarcinoma in the narrow sense) and 29 cases of the hilar type are described in comparison with those of hepatocellular carcinoma, with a review of the literature on the clinicopathological aspects of intrahepatic bile duct carcinoma. As compared with hepatocellular carcinoma, the average age of the patients was older; the male predominance was not obvious, chronic parenchymal liver disease was infrequent in the past history, association of primary cirrhosis was seldom, cholestatic features were frequently the early signs and more pronounced during the course, the liver was enlarged to a lesser extent, ascites was less common, signs of portal hypertension were absent or minimal, a n d extrahepatic metastases were less frequent. In many respects, the hilar type resembled extrahepatic bile duct carcinoma, and the peripheral type was somewhat between it and hepatocellular carcinoma. Although the overall survival was not much different from that for hepatocellular carcinoma, early diagnosis is emphasized; this would make surgical management possible. Differential diagnosis from hepatocellular carcinoma may be possible in the majority with direct cholangiography , liver scan, celiac angiography, determination of a-fetoprotein and hepatitis B antigen, and blood chemistry such as SCOT, SLDH, serum bilirubin and alkaline phosphatase. Illustrative cases are given including one patient with a hilar carcinoma who survived for more than 2 years after transhepatic biliary drainage.

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Section: A N C E R J U N U U R Y 1977mentioning

confidence: 99%

Clinical aspects of intrahepatic bile duct carcinoma including hilar carcinoma.A study of 57 autopsy-proven cases

Okuda

Kubo

Okazaki

et al. 1977

Cancer

249

116

View full text Add to dashboard Cite

show abstract

“…Furthermore, the operative survival rate for CCC seems very low, and only a few long-term survivors have been reported. [1][2][3][4][5]9 The poor operative survival rate for CCC patients may be attributable to several factors. First, early detection, achieved by following patients with high-risk factors such as chronic liver damage, as in patients with HCC, is difficult.…”

Section: Discussionmentioning

confidence: 99%

Nine-Year survivor after resection of cholangiocellular carcinoma with tumor thrombi in the main portal trunk

Sugiyama

Fujii

Konishi

et al. 1998

Journal of Gastroenterology

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We report a patient with cholangiocellular carcinoma with tumor thrombi in the main portal trunk who has survived for 9.5 years after hepatic resection. A 57-year-old woman underwent an extended left lobectomy, and resection of the caudate lobe plus the main portal trunk for a liver tumor that had a portal tumor thrombus in the main portal trunk. The portal vein was reconstructed with an autologous vein graft obtained from the external iliac vein. Histological examination of the resected specimen revealed moderately differentiated tubular adenocarcinoma compatible with cholangiocellular carcinoma. Factors contributing to the patient's long-term survival are discussed. Aggressive surgical resection can be effective even for such an advanced case of cholangiocellular carcinoma.

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“…Cholangiocellular carcinoma (CCC) carries a poor prognosis, and few patients survive for more than 3 years after operation . Unlike patients with hepatocellular carcinoma (HCC), patients with a high risk of CCC are difficult to identify, and most cases are very advanced at the time of diagnosis 5.…”

Section: Introductionmentioning

confidence: 99%

Cholangiocellular carcinoma in a patient who has survived for 6 years after extended left hepatic lobectomy and caudate lobe resection with pancreatoduodenectomy

Yamamoto

Takasaki

Tsugita

et al. 1996

J Hep Bil Pancr Surg

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Abstract:We describe a case of cholangiocellular carcinoma in a 66-year-old woman. A well-defined, hypoechoic tumor, 9 cm in greatest diameter, was detected in the left lobe of the liver by ultrasonography in December 1988. Celiac angiography showed a faintly stained tumor at the same location, with interruption of the left portal vein. Computed tomography revealed invasion of the inferior vena cava and lymph node enlargement around the head of the pancreas. In January 1989, the patient underwent extended left hepatic lobectomy with caudate lobe resection, pancreatoduodenectomy, partial resection of the inferior vena cava, and lymph node dissection around the hepatoduodenal ligament and the common hepatic artery. Postoperative histopathological examination revealed a moderately differentiated tubular adenocarcinoma. Cancer cells had invaded only the portal region, unlike the features of most cholangiocellular carcinomas. There was no evidence of lymph node metastasis in the dissected specimens. Six years after operation, there have been no signs of recurrence, and the patient is still alive and well.

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Cholangiocarcinoma of the liver:Case report with seven-year survival, with review of the literature on primary liver tumors and hepatic resections

Cited by 16 publications

References 33 publications

Clinical aspects of intrahepatic bile duct carcinoma including hilar carcinoma.A study of 57 autopsy-proven cases

Clinical aspects of intrahepatic bile duct carcinoma including hilar carcinoma.A study of 57 autopsy-proven cases

Nine-Year survivor after resection of cholangiocellular carcinoma with tumor thrombi in the main portal trunk

Cholangiocellular carcinoma in a patient who has survived for 6 years after extended left hepatic lobectomy and caudate lobe resection with pancreatoduodenectomy

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