Cholangiocarcinoma in association with Thorotrast exposure

Lauwers, Gregory Y.; Tanabe, Kenneth K.

doi:10.1007/s00534-004-0924-5

Cited by 28 publications

(12 citation statements)

References 10 publications

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“…Multiple case-control analyses have reported an association between cholangiocarcinoma and alcohol use (34;35). Several cases of cholangiocarcinoma have been described following the iatrogenic exposure to thorotrast (thorium dioxide), a radiocontrast agent used in the past (36). Toxin exposures may be linked to outbreaks of cholangiocarcinoma that have been noted in Italy, West Virginia, and British Columbia, although convincing evidence for any likely culprits is lacking.…”

Section: Risk Factorsmentioning

confidence: 99%

Cholangiocarcinoma: New Insights into Disease Pathogenesis and Biology

Braconi

Patel

2010

Infectious Disease Clinics of North America

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Synopsis Cholangiocarcinoma are rare malignant tumors whose incidence is increasing worldwide. Risk factors for this malignancy include biliary diseases characterized by chronic inflammation of the bile duct epithelia. Diagnosis of these cancers remains difficult due to the lack of sensitive diagnostic tests. The prognosis is poor likely due to the lack of effective treatments for unresectable cancer.

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Section: Risk Factorsmentioning

confidence: 99%

Cholangiocarcinoma: New Insights into Disease Pathogenesis and Biology

Braconi

Patel

2010

Infectious Disease Clinics of North America

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“…The etiology of ICC is poorly understood although several etiological factors, including hepatolithiasis [2], primary sclerosing cholangitis [3], liver flukes ( Clonorchis sinensis and Opisthorchis viverrini) [4] and exposure to the radiopaque medium thorium dioxide (Thorotrast) [5], has been well established.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis

Zhou

Zhao

et al. 2012

BMC Cancer

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BackgroundStudies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. We conducted a meta-analysis of epidemiological studies to explore this relationship.MethodsA comprehensive search was conducted to identify the eligible studies of hepatitis infections and ICC risk up to September 2011. Summary odds ratios (OR) with their 95% confidence intervals (95% CI) were calculated with random-effects models using Review Manager version 5.0.ResultsThirteen case–control studies and 3 cohort studies were included in the final analysis. The combined risk estimate of all studies showed statistically significant increased risk of ICC incidence with HBV and HCV infection (OR = 3.17, 95% CI, 1.88-5.34, and OR = 3.42, 95% CI, 1.96-5.99, respectively). For case–control studies alone, the combined OR of infection with HBV and HCV were 2.86 (95% CI, 1.60-5.11) and 3.63 (95% CI, 1.86-7.05), respectively, and for cohort studies alone, the OR of HBV and HCV infection were 5.39 (95% CI, 2.34-12.44) and 2.60 (95% CI, 1.36-4.97), respectively.ConclusionsThis study suggests that both HBV and HCV infection are associated with an increased risk of ICC.

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“…Major hepatectomy with lymphadenectomy is the treatment of choice for cholangiocarcinoma . Left hepatectomy occasionally leads to DGE ,.…”

Section: Introductionmentioning

confidence: 99%

“…Major hepatectomy with lymphadenectomy is the treatment of choice for cholangiocarcinoma. [1][2][3][4] Left hepatectomy occasionally leads to DGE. 5,6 Lymphadenectomy can also disrupt normal gastrointestinal movement.…”

Section: Introductionmentioning

confidence: 99%